Cell signalling articles from across Nature Portfolio

In-depth in vivo and in vitro functional analyses, along with a series of genomic assays, reveal RNF20 as a molecular rheostat controlling the balance between endothelial VEGF and Notch signaling during sprouting angiogenesis.

Carapeto et al. provide compelling evidence that exercise can have an inhibitory effect on cellular senescence in the pancreatic islets. Their results clearly demonstrate that serum collected postexercise can induce this effect in islets from either mice or humans.

The IRE1α-XBP1s pathway has been implicated in the regulation of anti-tumor immunity. Here the authors show that IRE1α is increased in prostate cancer (PCa) and that its inhibition reprograms the tumor microenvironment, promoting anti-tumor immune responses in PCa preclinical models.

Protein kinase C (PKC) enzymes are critical signaling molecules but their regulation at emerging signaling hubs is unclear. Here Su et al. develop a sensitive fluorescent biosensor, ExRai-CKAR2, and reveal distinct spatiotemporal regulation of different PKC isoforms in two-dimensional and three-dimensional models.

Abnormal subchondral bone remodeling plays a pivotal role in the progression of osteoarthritis. Here, the authors reveal a negative feedback loop, RANKL-UCHL1-sCD13, which limits osteoclastogenesis in the subchondral bone to prevent osteoarthritis progression.

In-depth in vivo and in vitro functional analyses, along with a series of genomic assays, reveal RNF20 as a molecular rheostat controlling the balance between endothelial VEGF and Notch signaling during sprouting angiogenesis.

Carapeto et al. provide compelling evidence that exercise can have an inhibitory effect on cellular senescence in the pancreatic islets. Their results clearly demonstrate that serum collected postexercise can induce this effect in islets from either mice or humans.