Cell polarity

Cell polarity is the asymmetric organisation of several cellular components, including its plasma membrane, cytoskeleton or organelles. This asymmetry can be used for specialised functions, such as maintaining a barrier within an epithelium or transmitting signals in neurons.

Featured

Latest Research and Reviews

News and Comment

  • News & Views |

    Polar cell growth requires spatiotemporal regulation of Rho of plants (ROPs) small G proteins in membrane domains. In addition to localized activation of membrane-anchored ROPs, a mechanism for their local inactivation has now been identified.

    • Gil Feiguelman
    •  & Shaul Yalovsky
    Nature Plants 6, 1201-1202
  • News & Views |

    Functional single-cell liver hemi-canaliculi have been generated in a synthetic microenvironment using a reductionist approach. It is shown that the interaction between the extracellular matrix and static cadherin is sufficient to develop an apicobasal polarity independently of the contact with neighbouring cells.

    • Covadonga Díaz-Díaz
    •  & Fernando Martín-Belmonte
    Nature Materials 19, 935-937
  • Research Highlights |

    In this Journal Club, Audrey Williams and Sally Horne-Badovinac highlight the importance of studying the basal cell surface and its dynamics to understand epithelial cell behaviours and tissue rearrangements.

    • Audrey M. Williams
    •  & Sally Horne-Badovinac
  • News & Views |

    Tangential expansion of neural stem cells in the mammalian neocortex increases the number of cortical columns. A new study shows that neural stem cells that become detached from the apical surface during division regenerate an apical endfoot to ensure tangential expansion in the early stage but later lose this ability when radial expansion occurs.

    • Masafumi Tsuboi
    •  & Yukiko Gotoh