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Open Access
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Letter |
Asymmetric lysosome inheritance predicts activation of haematopoietic stem cells
The cellular degradative machinery can be asymmetrically inherited upon haematopoietic-stem-cell division, which predicts the future metabolic and translational activation of their daughter cells.
- Dirk Loeffler
- , Arne Wehling
- & Timm Schroeder
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Letter |
LLGL2 rescues nutrient stress by promoting leucine uptake in ER+ breast cancer
The polarity protein LLGL2 supports tumour growth in breast cancer by promoting leucine uptake and adaptation to nutrient stress.
- Yasuhiro Saito
- , Lewyn Li
- & Senthil K. Muthuswamy
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Letter |
Nuclear positioning facilitates amoeboid migration along the path of least resistance
Geometrically defined microenvironments are used to show that leukocytes migrate along chemokine gradients using the nucleus as a mechanical gauge to sample potential paths and identify the path of least resistance.
- Jörg Renkawitz
- , Aglaja Kopf
- & Michael Sixt
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Letter |
Pluripotent state transitions coordinate morphogenesis in mouse and human embryos
Exit of epiblasts from an unrestricted naive pluripotent state is required for epithelialization and generation of the pro-amniotic cavity in mouse embryos and for amniotic cavity formation in human embryos and human embryonic stem cells.
- Marta N. Shahbazi
- , Antonio Scialdone
- & Magdalena Zernicka-Goetz
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Letter |
Polarized endosome dynamics by spindle asymmetry during asymmetric cell division
Central spindle asymmetry, generated by the kinesin Klp10A and its antagonist Patronin, polarizes endosome motility and provides a mechanism for the asymmetric segregation of signalling endosomes observed in a variety of asymmetrically dividing cell types.
- Emmanuel Derivery
- , Carole Seum
- & Marcos Gonzalez-Gaitan
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Article |
ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner
ZNRF3 and RNF43 are identified as negative feedback regulators of Wnt signalling; the stem-cell growth factor R-spondin is shown to potentiate Wnt signalling by inhibiting ZNRF3.
- Huai-Xiang Hao
- , Yang Xie
- & Feng Cong
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Letter |
Anisotropies in cortical tension reveal the physical basis of polarizing cortical flows
In the one-cell Caenorhabditis elegans embryo, anteroposterior polarization is facilitated by large-scale flow of the actomyosin cortex, which segregates cortical polarity proteins into anterior and posterior domains. The underlying forces and physical principles behind long-range flow are unclear. Here, a new method is described by which to measure cortical tension. The results identify two prerequisites for large-scale cortical flow: a gradient in actomyosin contractility and a sufficiently large viscosity of the cortex.
- Mirjam Mayer
- , Martin Depken
- & Stephan W. Grill
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Letter |
Planar cell polarity breaks bilateral symmetry by controlling ciliary positioning
During vertebrate development, the dorsal–ventral and anterior–posterior (A–P) body axes are determined first, after which left–right (L–R) asymmetry is established. But the molecular mechanism by which L–R symmetry is broken in reference to the other two axes is poorly understood. Here it is shown that two mouse genes, Vang1 and Vang2, which belong to the planar cell polarity family, are required to interpret the A–P patterning information and link it to L–R asymmetry.
- Hai Song
- , Jianxin Hu
- & Yingzi Yang
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Endocytosis in the axon initial segment maintains neuronal polarity