Cell lineage

A cell lineage is the developmental history of a differentiated cell as traced back to the cell from which it arises. The cells of some organisms, such as C. elegans, have invariant lineages between individuals, whereas vertebrate cell lineage patterns are more variable.

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Latest Research and Reviews

  • Research |

    Gao, Nowak-Imialek, Chen et al. generate porcine and human stem cells that possess expanded developmental potency for both embryonic and extra-embryonic cell lineages.

    • Xuefei Gao
    • , Monika Nowak-Imialek
    • , Xi Chen
    • , Dongsheng Chen
    • , Doris Herrmann
    • , Degong Ruan
    • , Andy Chun Hang Chen
    • , Melanie A. Eckersley-Maslin
    • , Shakil Ahmad
    • , Yin Lau Lee
    • , Toshihiro Kobayashi
    • , David Ryan
    • , Jixing Zhong
    • , Jiacheng Zhu
    • , Jian Wu
    • , Guocheng Lan
    • , Stoyan Petkov
    • , Jian Yang
    • , Liliana Antunes
    • , Lia S. Campos
    • , Beiyuan Fu
    • , Shengpeng Wang
    • , Yu Yong
    • , Xiaomin Wang
    • , Song-Guo Xue
    • , Liangpeng Ge
    • , Zuohua Liu
    • , Yong Huang
    • , Tao Nie
    • , Peng Li
    • , Donghai Wu
    • , Duanqing Pei
    • , Yi Zhang
    • , Liming Lu
    • , Fengtang Yang
    • , Susan J. Kimber
    • , Wolf Reik
    • , Xiangang Zou
    • , Zhouchun Shang
    • , Liangxue Lai
    • , Azim Surani
    • , Patrick P. L. Tam
    • , Asif Ahmed
    • , William Shu Biu Yeung
    • , Sarah A. Teichmann
    • , Heiner Niemann
    •  & Pentao Liu
    Nature Cell Biology 21, 687-699
  • Research |

    A multi-channel molecular recording technique is applied as a lineage tracer to assemble cell-fate maps from fertilization through gastrulation in the mouse, providing insights into ontogeny in a complex multicellular organism.

    • Michelle M. Chan
    • , Zachary D. Smith
    • , Stefanie Grosswendt
    • , Helene Kretzmer
    • , Thomas M. Norman
    • , Britt Adamson
    • , Marco Jost
    • , Jeffrey J. Quinn
    • , Dian Yang
    • , Matthew G. Jones
    • , Alex Khodaverdian
    • , Nir Yosef
    • , Alexander Meissner
    •  & Jonathan S. Weissman
    Nature 570, 77-82
  • Research | | open

    Haematopoietic stem and progenitor cells (HSPCs) produce all blood lineages and arise from the haemogenic endothelium (HE) during embryogenesis. Here the authors show that genes specific to cilia formation are required for HSPC development in the HE in zebrafish through transduction of Notch signal.

    • Zhibin Liu
    • , Haiqing Tu
    • , Yunsi Kang
    • , Yuanyuan Xue
    • , Dongyuan Ma
    • , Chengtian Zhao
    • , Huiyan Li
    • , Lu Wang
    •  & Feng Liu

News and Comment

  • News and Views |

    Embryonic stem cells derived from the inner cell mass can differentiate to all embryonic lineages of any adult cell type and to a limited extent to extra-embryonic tissues. A study now allows the generation of pig and human stem cells with enhanced differentiation potential towards all embryonic and extra-embryonic fates, one step closer to the totipotent state of the fertilized egg.

    • Fred Etoc
    •  & Ali Brivanlou
    Nature Cell Biology 21, 671-673
  • Research Highlights |

    A study in Nature describes a CRISPR–Cas9-based ‘molecular recorder’ that can report on cellular state and cell lineage, in mice, from fertilization through to adulthood.

    • Katharine H. Wrighton
  • Research Highlights |

    A new study in Science reports the existence of a subpopulation of somatic cells from which ‘elite’ clones emerge that outperform other clones to drive reprogramming.

    • Linda Koch
  • News and Views |

    Osteoclasts are known for their role in bone resorption. A study now shows that a vascular–associated osteoclast subtype at the growth plate also regulates blood vessel growth in bone and is supported by type H endothelial cells. These type H capillaries, in turn, release proteinases that promote cartilage degradation.

    • Jameel Iqbal
    •  & Mone Zaidi
    Nature Cell Biology 21, 417-419