Cell lineage

A cell lineage is the developmental history of a differentiated cell as traced back to the cell from which it arises. The cells of some organisms, such as C. elegans, have invariant lineages between individuals, whereas vertebrate cell lineage patterns are more variable.

Latest Research and Reviews

News and Comment

  • News & Views |

    Facchinello, Astone et al. demonstrate a role for the endothelial oxidative pentose phosphate pathway (oxPPP) in promoting vascular mural cell coverage and maturation during early development by regulating elastin expression. This mechanism establishes a critical role for oxPPP in the formation of the vascular system.

    • Olga A. Cherepanova
    •  & Tatiana V. Byzova
  • Research Highlights |

    A study in Nature Genetics applies whole-genome sequencing to monozygotic twins, their parents, partners and offspring to identify and characterize early developmental mutations, as well as the fate of mutated cells.

    • Linda Koch
  • Research Highlights |

    A recent study combines CRISPR-based perturbation with single-cell RNA sequencing to characterize the roles of epigenome regulator proteins in controlling cell fate and identity during embryonic development.

    • Darren J. Burgess
  • Research Highlights |

    A study in Science describes the generation of a lineage-resolved single-cell transcriptome atlas for Caenorhabditis elegans embryos. This resource provides insight into the transcriptional changes underlying cell fate decisions.

    • Dorothy Clyde