Cell invasion

Cell invasion is related to cell migration, and defines the ability of cells to become motile and to navigate through the extracellular matrix within a tissue or to infiltrate neighbouring tissues. Cancer cells that become invasive may disseminate to secondary sites and form metastases.

Latest Research and Reviews

News and Comment

  • Research Highlights |

    Venkataramani et al. used longitudinal intravital two-photon imaging to track migrating glioblastoma cells in vivo, and identified a seemingly unconnected cell subpopulation that was responsible for colonization of the brain by mimicking neuronal mechanisms of movement.

    • Anna Dart
    Nature Reviews Cancer 22, 548-549
  • News & Views |

    EGFR is an oncogene that is frequently amplified in glioblastoma. A new study suggests a tumour-suppressive role of EGFR in EGFR-amplified glioblastoma regulated by ligand abundance. Increased EGFR ligand in EGFR-amplified glioblastoma suppresses invasion by upregulating BIN3 and inhibiting activation of Rho GTPases.

    • Mary Clare Beytagh
    •  & William A. Weiss
    Nature Cell Biology 24, 1189-1191
  • News & Views |

    Epithelial–mesenchymal transition (EMT) is crucial for development, and for dissemination and invasion of cancer cells. A study now identifies the apical–basolateral polarity status of epithelia as a checkpoint for EMT induction and tumour metastasis through aPKC–Par3-regulated degradation of the EMT transcription factor SNAI1.

    • Oana-Diana Persa
    •  & Carien M. Niessen
    Nature Cell Biology 21, 299-300
  • Research Highlights |

    Mechanical coupling of cancer-associated fibroblasts and cancer cells through a heterotypic E-cadherin–N-cadherin adherens junction promotes cancer cell invasion.

    • Anna Dart