CD8-positive T cells

CD8-positive T cells are a critical subpopulation of MHC class I-restricted T cell and are mediators of adaptive immunity. They include cytotoxic T cells, which are important for killing cancerous or virally infected cells, and CD8-positive suppressor T cells, which restrain certain types of immune response.

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Latest Research and Reviews

  • Research | | open

    Senescent cells increase with ageing and may cause inflammatory conditions, but how this accumulation is mediated is still unclear. Here the authors show that senescent cells express HLA-E to suppress NKG2A-mediated natural killer and CD8 T cell activation to avoid targeted elimination, while blocking NKG2A helps promote immunity against senescent cells.

    • Branca I. Pereira
    • , Oliver P. Devine
    • , Milica Vukmanovic-Stejic
    • , Emma S. Chambers
    • , Priya Subramanian
    • , Neil Patel
    • , Alex Virasami
    • , Neil J. Sebire
    • , Veronica Kinsler
    • , Alexis Valdovinos
    • , Claude Jourdan LeSaux
    • , João F. Passos
    • , Antony Antoniou
    • , Malcom H. A. Rustin
    • , Judith Campisi
    •  & Arne N. Akbar
  • Research | | open

    Viral rebound following discontinuation of antiretroviral therapy (ART) is a major obstacle for HIV cure. Here, the authors show that adoptive cellular therapy using autologous Env-specific T cells augmented by therapeutic vaccination can control viral rebound after ART interruption in a SHIV macaque model.

    • Jin Fan
    • , Hua Liang
    • , Xiaolin Ji
    • , Shuo Wang
    • , Jing Xue
    • , Dan Li
    • , Hong Peng
    • , Chuan Qin
    • , Cassian Yee
    •  & Yiming Shao
  • Research |

    Tissue-resident memory T (TRM) cells have been studied mainly in mouse models. Schumacher and colleagues have developed an imaging technology to track in real time skin-resident human CD8+ TRM cells in situ.

    • Feline E. Dijkgraaf
    • , Tiago R. Matos
    • , Mark Hoogenboezem
    • , Mireille Toebes
    • , David W. Vredevoogd
    • , Marjolijn Mertz
    • , Bram van den Broek
    • , Ji-Ying Song
    • , Marcel B. M. Teunissen
    • , Rosalie M. Luiten
    • , Joost B. Beltman
    •  & Ton N. Schumacher
    Nature Immunology 20, 756-764
  • Research | | open

    The inability of T cells to properly mount anti-tumour immunity underlies failed cancer immune surveillance or therapy. Here the authors show that a microRNA, miR-155, suppresses Ship1 phosphatase expression to modulate epigenetic reprogramming of CD8 T cell differentiation via the Phf19/PRC2 axis, thereby implicating a novel aspect of cancer immunity regulation.

    • Yun Ji
    • , Jessica Fioravanti
    • , Wei Zhu
    • , Hongjun Wang
    • , Tuoqi Wu
    • , Jinhui Hu
    • , Neal E. Lacey
    • , Sanjivan Gautam
    • , John B. Le Gall
    • , Xia Yang
    • , James D. Hocker
    • , Thelma M. Escobar
    • , Shan He
    • , Stefania Dell’Orso
    • , Nga V. Hawk
    • , Veena Kapoor
    • , William G. Telford
    • , Luciano Di Croce
    • , Stefan A. Muljo
    • , Yi Zhang
    • , Vittorio Sartorelli
    •  & Luca Gattinoni
  • Research | | open

    Immune cells may become less responsive, or ‘exhausted’, upon chronic viral infection, but the underlying mechanism and crosstalk are still unclear. Here the authors show that, upon chronic hepatitis C virus (HCV) infection, natural killer cell exhaustion is induced by NKG2A signalling to instruct downstream exhaustion of CD8+ T cells and HCV persistence.

    • Chao Zhang
    • , Xiao-mei Wang
    • , Shu-ran Li
    • , Trix Twelkmeyer
    • , Wei-hong Wang
    • , Sheng-yuan Zhang
    • , Shu-feng Wang
    • , Ji-zheng Chen
    • , Xia Jin
    • , Yu-zhang Wu
    • , Xin-wen Chen
    • , Sheng-dian Wang
    • , Jun-qi Niu
    • , Hai-rong Chen
    •  & Hong Tang

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