CD8-positive T cells

CD8-positive T cells are a critical subpopulation of MHC class I-restricted T cell and are mediators of adaptive immunity. They include cytotoxic T cells, which are important for killing cancerous or virally infected cells, and CD8-positive suppressor T cells, which restrain certain types of immune response.


Latest Research and Reviews

News and Comment

  • News & Views |

    T cell responses probably play important roles in the control of SARS-CoV-2 infection, but they have been relatively understudied. Data now suggest that the majority of infected individuals develop robust and long-lasting T cell immunity, which has implications for the durability of immunity and future vaccine approaches.

    • Prasanna Jagannathan
    •  & Taia T. Wang
    Nature Immunology 22, 539-540
  • Research Highlights |

    New research published in Immunity suggests that the increased rigidity of cancer cells during metastasis can result in a biophysical vulnerability to killing by cytotoxic lymphocytes through a form of mechanosurveillance.

    • Kirsty Minton
  • News & Views |

    Long-term pathogen and tumor control as well as checkpoint immunotherapies rely on ‘stem-like’ CD8+ T cells. New results uncover BACH2 as a key regulator of this subpopulation and solve an important piece of the puzzle.

    • Lara Labarta-Bajo
    •  & Elina I. Zúñiga
    Nature Immunology 22, 274-276
  • News & Views |

    An investigation of the molecular processes of mitochondrial reprogramming and metabolic stress in antigen-experienced T cells within tumor microenvironments reveals mechanisms responsible for T cell exhaustion and dysfunction and facilitates the development of new strategies for tumor immunotherapy.

    • Xia Liu
    •  & Guangyong Peng
    Nature Immunology 22, 276-278
  • News & Views |

    Comprehensive analysis of specific and cross-reactive SARS-CoV-2 epitopes reveals functional T cell responses against specific viral regions in essentially all convalescent individuals and a majority of unexposed donors, demonstrating that cross-reactive responses to COVID-19 are widespread.

    • André Perez-Potti
    • , Joshua Lange
    •  & Marcus Buggert