Cartilage articles within Nature Communications

Featured

  • Article
    | Open Access

    There is a strong need for the development of effective and safe disease-modifying osteoarthritis drugs. Here, the authors show that 5-ASA, an anti-inflammatory drug used for ulcerative colitis, shows promise in treating osteoarthritis in mice by improving cartilage and reducing inflammation even when administered at late stages of disease.

    • Jihee Kim
    • , Gina Ryu
    •  & Soo Young Lee

  • Article
    | Open Access

    The 24-hour circadian clocks in cartilage and intervertebral disc play key roles in regulating tissue physiology, yet how they are reset on a daily basis remains elusive. Here the authors show that daily patterns of mechanical loading and associated changes in osmolarity provide a tissue-type specific entrainment time cue for these skeletal clocks.

    • Michal Dudek
    • , Dharshika R. J. Pathiranage
    •  & Qing-Jun Meng

  • Article
    | Open Access

    Ji and colleagues identify Sirt6 as a regulator of chondrocyte senescence. Mechanistically, Sirt6 physically interacts with STAT5 and deacetylates it at K163, which reduces the IL-15/JAK3-induced STAT5 translocation from cytoplasm to nucleus.

    • Ming-liang Ji
    • , Hua Jiang
    •  & Jun Lu

  • Article
    | Open Access

    Current treatments cannot significantly alleviate the radiographic progression in ankylosing spondylitis (AS), which results in joints stiffness and bony fusion of AS. Smo inhibitor sonidegib retards the pathological new bone formation in AS through targeting dysfunctional chondrogenesis.

    • Fenli Shao
    • , Qianqian Liu
    •  & Yang Sun

  • Article
    | Open Access

    Osteoarthritis is a chronic, heritable disease with no available treatment. Here, the authors show that a validated, rapid-throughput joint phenotyping pipeline detects osteoarthritis in the mouse knee following surgical provocation, in aging and after single gene deletion or point mutation.

    • Natalie C. Butterfield
    • , Katherine F. Curry
    •  & J. H. Duncan Bassett

  • Article
    | Open Access

    Chondrocytes have altered cellular metabolism in the context of osteoarthritis, but whether and how these changes are associated with inflammation is a controversial area. Here the authors show that inflammatory NF-κB signalling drives a glycolytic shift in chondrocytes and the production of ROS, which drives cartilage catabolism.

    • Manoj Arra
    • , Gaurav Swarnkar
    •  & Yousef Abu-Amer

  • Article
    | Open Access

    Arthroplasty is the main clinical option for the treatment of osteoarticular lesions, but has limited efficacy. Here, the authors use a wound dressing with autologous mesenchymal stromal cells, functionalised for local BMP2 delivery, and show feasibility and safety in standardised preclinical tests in animal models, suggesting suitability for use in clinical trials.

    • Laetitia Keller
    • , Luc Pijnenburg
    •  & Nadia Benkirane-Jessel

  • Article
    | Open Access

    Osteoarthritis is characterised by degeneration of joint cartilage. Here the authors show that the RNA-binding protein ZFP36L1 is upregulated in chondrocytes of humans and mice with osteoarthritis, and that its knockdown in mouse joints protects chondrocytes against apoptosis by modulating the function of heat shock proteins.

    • Young-Ok Son
    • , Hyo-Eun Kim
    •  & Jang-Soo Chun

  • Article
    | Open Access

    The stem cells that maintain and repair adult joint tissues in mammals, including articular cartilage, remain incompletely defined. Here the authors perform lineage tracing studies in adult mice and find an ontogenetically defined progenitor cell population that is functional in the synovial joint and distinct from previously reported mesenchymal stem cell populations.

    • Anke J. Roelofs
    • , Janja Zupan
    •  & Cosimo De Bari

  • Article
    | Open Access

    A potentially superior tissue regenerative strategy to stem cell transplantation is modulation of endogenous stem cells. Here the authors show fibrocartilage stem cells exist in the temporomandibular joint that contribute to cartilage regeneration and can be manipulated to enhance regeneration through canonical Wnt signalling.

    • Mildred C. Embree
    • , Mo Chen
    •  & Jeremy J. Mao

  • Article
    | Open Access

    Therapies are needed for the prevention of chondrocyte hypertrophy and thinning of articular cartilage, features of osteoarthritic joint destruction. Here, the authors show that interfering with Sik3 signalling can increase the size of the chondrocyte population and reduce severity of a surgically induced mouse model of osteoarthritis.

    • Yasuhito Yahara
    • , Hiroshi Takemori
    •  & Noriyuki Tsumaki

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