Cardiovascular models articles within Nature Communications

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  • Article
    | Open Access

    The application of engineered cardiac tissues is limited due to their immaturity and lack of functionality. Here, the authors develop an integrated culture platform featuring heart extracellular matrix cultured in a microfluidic chip to facilitate cardiac tissue development for versatile biomedical applications.

    • Sungjin Min
    • , Suran Kim
    •  & Seung-Woo Cho

  • Article
    | Open Access

    Advancements in congenital heart surgery stress the need for durable biomaterials. Here, the authors compare tissue-engineered vascular grafts (TEVGs) with traditional polytetrafluoroethylene grafts, revealing TEVGs’ superior durability and reduced calcification, promising improved long-term success for surgeries.

    • Mackenzie E. Turner
    • , Kevin M. Blum
    •  & Christopher K. Breuer

  • Article
    | Open Access

    The study of the pathophysiology and possible interventions for non-ST-segment elevation myocardial infarction is hindered by the lack of a reproducible pre-clinical model. Here, authors develop an ovine model to reproduce post-ischemic remodeling in non-ST myocardial infarction and reveal distinct complex sugar moieties in cellular membranes and extracellular matrix patterns in infarcted tissue.

    • Paolo Contessotto
    • , Renza Spelat
    •  & Mark Da Costa

  • Article
    | Open Access

    Investigations of human cardiac disease involving human pluripotent stem cell-derived cardiomyocytes are limited by the disorganized presentation of biomechanical cues resulting in cell immaturity. Here the authors develop a platform of micron-scale 2D cardiac muscle bundles to precisely deliver physiologic cues, improving reproducibility and throughput.

    • Yao-Chang Tsan
    • , Samuel J. DePalma
    •  & Adam S. Helms

  • Article
    | Open Access

    There is a pressing need to develop representative organ-like platforms recapitulating complex in vivo phenotypes to study human development and disease in vitro. Here the authors present a method to generate human heart organoids by self-assembly using pluripotent stem cells, compare these to age-matched fetal cardiac tissues and recreate a model of pregestational diabetes.

    • Yonatan R. Lewis-Israeli
    • , Aaron H. Wasserman
    •  & Aitor Aguirre

  • Article
    | Open Access

    Current tissue engineering strategies lack materials that promote angiogenesis. Here the authors develop a microfluidic in vitro model in which chemokine-guided endothelial cell sprouting into a tunable hydrogel is followed by the formation of perfusable lumens to determine the material properties that regulate angiogenesis.

    • Jifeng Liu
    • , Hongyan Long
    •  & Britta Trappmann

  • Article
    | Open Access

    A mutation in Shugoshin-1 causes the Chronic Atrial and Intestinal Dysrhythmia (CAID) Syndrome, but the underlying mechanisms are unknown. Here, the authors show that Shugoshin-1 controls cardiac pacemaker activity by interacting with HCN4 to enhance its cell-surface expression, and that the CAID-Syndrome mutation disrupts cardiac pacemaking by interfering with this important non-canonical interaction.

    • Donghai Liu
    • , Andrew Taehun Song
    •  & Stanley Nattel

  • Article
    | Open Access

    Cellular models are needed to study disease in vitro and to screen drugs for toxicity and efficacy. Here the authors develop a bioprinting approach to transfer spheroids into self-healing support hydrogels at high resolution, which enables their patterning and fusion into high-cell density microtissues of prescribed spatial organization.

    • Andrew C. Daly
    • , Matthew D. Davidson
    •  & Jason A. Burdick

  • Article
    | Open Access

    Cultured adult cardiac tissue undergoes rapid dedifferentiation, which hinders chronic in vitro studies. Here the authors investigate biomimetic electromechanical stimulation of adult myocardial slices applying different preload conditions, identifying the optimum sarcomere length for prolonged culturing, and investigating transcriptional profiles associated with functional preservation.

    • Samuel A. Watson
    • , James Duff
    •  & Cesare M. Terracciano

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