Cardiovascular diseases

Cardiovascular diseases are pathological conditions affecting the heart and/or blood vessels – that is, the cardiovascular system.

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Latest Research and Reviews

News and Comment

  • News and Views |

    The global burden of cardiovascular disease morbidity and mortality demands increased awareness of effective prevention strategies by patients, communities and health-care providers. The new 2019 ACC/AHA guidelines provide evidence-based, preventive recommendations for patients without known cardiovascular disease, focusing on risk estimation, a healthy lifestyle and selective indications for pharmacotherapy.

    • Rhanderson Cardoso
    •  & Khurram Nasir
  • Research Highlights |

    Neutrophils exacerbate tissue damage and inflammation in advanced atherosclerosis by triggering smooth muscle cell (SMC) lysis and death. Lesional neutrophils release neutrophil extracellular traps that contain histone H4, which interacts with SMCs to induce cell lysis, leading to the destabilization of atherosclerotic plaques.

    • Irene Fernández-Ruiz
  • News and Views |

    The entry of remnants of cholesterol-rich lipoproteins, such as low-density lipoprotein (LDL), from the blood stream into the intima of large arteries initiates and then perpetuates atherosclerosis. A study published in Nature sheds new light on this important process by identifying scavenger receptor BI (SR-BI) as a major receptor that mediates LDL delivery across the endothelium into arteries.

    • Xinbo Zhang
    •  & Carlos Fernández-Hernando
  • Research Highlights |

    High-sensitivity troponin I levels are positively and strongly linked with incident coronary heart disease, heart failure hospitalization and all-cause mortality in individuals without known cardiovascular disease.

    • Karina Huynh