Cardiology

Definition

Cardiology is a medical specialty that is concerned with the structure and function of the heart and vasculature, and the diagnosis and treatment of patients with cardiovascular diseases.

Featured

Latest Research and Reviews

  • Reviews |

    This Review summarizes the mechanisms of ectopic calcification processes in the cardiovascular system, with an emphasis on emerging knowledge obtained from advances in imaging methods, experimental models and multiomics-generated big data. This Review highlights the potential and challenges of artificial intelligence, machine learning and deep learning to integrate imaging and mechanistic data to identify biomarkers and effective treatments for cardiovascular calcification

    • Maximillian A. Rogers
    •  & Elena Aikawa
  • Research | | open

    Studying the genetic underpinnings of physical activity and sleep duration can be confounded by self-reporting. Here, Doherty et al. use data from 91,105 UK Biobank participants, whose activity had been monitored for a week by a wearable device, for genome-wide association analysis and identify 14 loci.

    • Aiden Doherty
    • , Karl Smith-Byrne
    • , Teresa Ferreira
    • , Michael V. Holmes
    • , Chris Holmes
    • , Sara L. Pulit
    •  & Cecilia M. Lindgren
  • Research |

    α1,3-galactosyltransferase-knockout pig hearts that express human CD46 and human thrombomodulin require non-ischaemic preservation with continuous perfusion and post-transplantation growth control to ensure long-term orthotopic function of the xenograft in baboons.

    • Matthias Längin
    • , Tanja Mayr
    • , Bruno Reichart
    • , Sebastian Michel
    • , Stefan Buchholz
    • , Sonja Guethoff
    • , Alexey Dashkevich
    • , Andrea Baehr
    • , Stefanie Egerer
    • , Andreas Bauer
    • , Maks Mihalj
    • , Alessandro Panelli
    • , Lara Issl
    • , Jiawei Ying
    • , Ann Kathrin Fresch
    • , Ines Buttgereit
    • , Maren Mokelke
    • , Julia Radan
    • , Fabian Werner
    • , Isabelle Lutzmann
    • , Stig Steen
    • , Trygve Sjöberg
    • , Audrius Paskevicius
    • , Liao Qiuming
    • , Riccardo Sfriso
    • , Robert Rieben
    • , Maik Dahlhoff
    • , Barbara Kessler
    • , Elisabeth Kemter
    • , Katharina Klett
    • , Rabea Hinkel
    • , Christian Kupatt
    • , Almuth Falkenau
    • , Simone Reu
    • , Reinhard Ellgass
    • , Rudolf Herzog
    • , Uli Binder
    • , Günter Wich
    • , Arne Skerra
    • , David Ayares
    • , Alexander Kind
    • , Uwe Schönmann
    • , Franz-Josef Kaup
    • , Christian Hagl
    • , Eckhard Wolf
    • , Nikolai Klymiuk
    • , Paolo Brenner
    •  & Jan-Michael Abicht
    Nature, 1–4
  • Reviews |

    Stent thrombosis is a rare but severe complication of coronary intervention and has a complex underlying pathophysiology. In this Review, Gori and colleagues describe the risk factors for stent thrombosis and discuss how a better understanding of the mechanisms underlying this complication can inform its prevention and treatment.

    • Tommaso Gori
    • , Alberto Polimeni
    • , Ciro Indolfi
    • , Lorenz Räber
    • , Tom Adriaenssens
    •  & Thomas Münzel
  • Research | | open

    Histone lysine demethylases (KDMs) can mediate transcriptional reprogramming in disease states. Here the authors show that KDM3A promotes left ventricular hypertrophy and cardiac fibrosis by activating the transcription of Timp1, and that pharmacological inhibition of KDM3A attenuates cardiac remodeling induced by pressure overload.

    • Qing-Jun Zhang
    • , Tram Anh T. Tran
    • , Ming Wang
    • , Mark J. Ranek
    • , Kristen M. Kokkonen-Simon
    • , Jason Gao
    • , Xiang Luo
    • , Wei Tan
    • , Viktoriia Kyrychenko
    • , Lan Liao
    • , Jianming Xu
    • , Joseph A. Hill
    • , Eric N. Olson
    • , David A. Kass
    • , Elisabeth D. Martinez
    •  & Zhi-Ping Liu

News and Comment