Carbohydrate chemistry

Carbohydrate chemistry deals with the reactions and synthesis of, often biologically important, carbohydrate molecules including monosaccharides, polysaccharides and their derivatives. Carbohydrate synthesis is dominated by methods for the stereoselective formation of carbon–oxygen bonds and the selective reaction of multiple hydroxyl (OH) groups.

Latest Research and Reviews

News and Comment

  • Research Highlights |

    Advanced 17O NMR methods can help distinguish oxygen atoms from different hydrogen-bonding environments in glucose.

    • Stacey-Lynn Paiva
  • News & Views |

    Complementary genomic frameworks for taxonomic classification of viruses infecting bacteria and archaea reveal evolutionary drivers, mosaicism and perspective on the genetic diversity of the tiniest, most abundant biological entities on Earth.

    • Emiley A. Eloe-Fadrosh
    Nature Microbiology 4, 1249-1250
  • News & Views |

    Enzymatic approaches to synthesize oligosaccharides offer an alternative to chemical syntheses for the production of homogeneous glycans; however, enzyme-based routes typically require lengthy processes. Now, the design of a water-soluble affinity tag has enabled the automation of multistep enzymatic syntheses of mammalian oligosaccharides.

    • Nicola L. B. Pohl
    Nature Chemistry 11, 201-203
  • News & Views |

    The reactivity of glycosyl donors is often explained by invoking putative glycosyl cation intermediates but, until now, they have not been observed in the condensed phase.

    • Luis Bohé
    •  & David Crich
    Nature Chemistry 8, 99-100
  • News & Views |

    Fullerene-based dendritic structures coated with 120 sugars can be made in high yields in a relatively short sequence of reactions. The mannosylated compound is shown to inhibit Ebola infection in cells more efficiently than monofullerene-based glycoclusters.

    • Sébastien Vidal
  • News & Views |

    Deoxygenation reactions have been used to convert biomass-derived carbohydrates into useful platform chemicals. Now, a method has been described that can selectively excise C–O bonds to produce valuable chiral synthons.

    • Andrew McNally
    Nature Chemistry 7, 539-541