Cancer immunotherapy

Cancer immunotherapy is a therapy used to treat cancer patients that involves or uses components of the immune system. Some cancer immunotherapies consist of antibodies that bind to, and inhibit the function of, proteins expressed by cancer cells. Other cancer immunotherapies include vaccines and T cell infusions.

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Latest Research and Reviews

  • Reviews |

    The therapeutic options currently available for patients with metastatic renal cell carcinoma (RCC) include immune-checkpoint inhibitors, novel targeted agents and combination strategies, and thus optimal patient selection and treatment sequencing are important. The authors review relevant aspects of the molecular biology of metastatic RCC, with an emphasis on biomarkers, and suggest tailored algorithms to individualize and guide treatment approaches

    • Ritesh R. Kotecha
    • , Robert J. Motzer
    •  & Martin H. Voss
  • Reviews |

    The authors of this Review propose a new model in which dynamic fluctuations of protein expression at the single-cell level and longitudinal reshaping of the cellular state at the cell-population level explain the process of therapeutic resistance development in patients with melanoma.

    • Xue Bai
    • , David E. Fisher
    •  & Keith T. Flaherty
  • Research |

    In situ vaccine recruits and activates cross-presenting dendritic cells and augments PD1 blockade efficacy in patients with indolent non-Hodgkin’s lymphoma.

    • Linda Hammerich
    • , Thomas U. Marron
    • , Ranjan Upadhyay
    • , Judit Svensson-Arvelund
    • , Maxime Dhainaut
    • , Shafinaz Hussein
    • , Yougen Zhan
    • , Dana Ostrowski
    • , Michael Yellin
    • , Henry Marsh
    • , Andres M. Salazar
    • , Adeeb H. Rahman
    • , Brian D. Brown
    • , Miriam Merad
    •  & Joshua D. Brody
  • Research | | open

    Certain chemotherapeutic agents can exert their anticancer effect through indirect immune-dependent mechanism. Here, the authors screen a library of tyrosine kinase inhibitors and show that crizotinib is an effective stimulator of immunogenic cell death and can potentiate the efficacy of immune checkpoint blockade.

    • Peng Liu
    • , Liwei Zhao
    • , Jonathan Pol
    • , Sarah Levesque
    • , Adriana Petrazzuolo
    • , Christina Pfirschke
    • , Camilla Engblom
    • , Steffen Rickelt
    • , Takahiro Yamazaki
    • , Kristina Iribarren
    • , Laura Senovilla
    • , Lucillia Bezu
    • , Erika Vacchelli
    • , Valentina Sica
    • , Andréa Melis
    • , Tiffany Martin
    • , Lin Xia
    • , Heng Yang
    • , Qingqing Li
    • , Jinfeng Chen
    • , Sylvère Durand
    • , Fanny Aprahamian
    • , Deborah Lefevre
    • , Sophie Broutin
    • , Angelo Paci
    • , Amaury Bongers
    • , Veronique Minard-Colin
    • , Eric Tartour
    • , Laurence Zitvogel
    • , Lionel Apetoh
    • , Yuting Ma
    • , Mikael J. Pittet
    • , Oliver Kepp
    •  & Guido Kroemer
  • Research | | open

    RNF5 is a ubiquitin ligase regulating ER stress response. Here the authors show that Rnf5 deficiency potentiates immune response against melanoma via altered microbiota, and isolate bacterial strains that confer the same phenotype to wild type mice.

    • Yan Li
    • , Roberto Tinoco
    • , Lisa Elmén
    • , Igor Segota
    • , Yibo Xian
    • , Yu Fujita
    • , Avinash Sahu
    • , Raphy Zarecki
    • , Kerrie Marie
    • , Yongmei Feng
    • , Ali Khateb
    • , Dennie T. Frederick
    • , Shiri K. Ashkenazi
    • , Hyungsoo Kim
    • , Eva Guijarro Perez
    • , Chi-Ping Day
    • , Rafael S. Segura Muñoz
    • , Robert Schmaltz
    • , Shibu Yooseph
    • , Miguel A. Tam
    • , Tongwu Zhang
    • , Emily Avitan-Hersh
    • , Lihi Tzur
    • , Shoshana Roizman
    • , Ilanit Boyango
    • , Gil Bar-Sela
    • , Amir Orian
    • , Randal J. Kaufman
    • , Marcus Bosenberg
    • , Colin R. Goding
    • , Bas Baaten
    • , Mitchell P. Levesque
    • , Reinhard Dummer
    • , Kevin Brown
    • , Glenn Merlino
    • , Eytan Ruppin
    • , Keith Flaherty
    • , Amanda Ramer-Tait
    • , Tao Long
    • , Scott N. Peterson
    • , Linda M. Bradley
    •  & Ze’ev A. Ronai

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