Calcium signalling

Calcium signalling is activated by calcium ions that are released from intracellular stores, or enter the cell via plasma membrane ion channels. Calcium is an important second messenger that regulates many cellular activities, including fertilisation, secretion, neurotransmission and cell migration.

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Latest Research and Reviews

  • Research |

    Carreras-Sureda et al. uncover a non-canonical role for IRE1α as a scaffold that stabilizes InsP3Rs at MAMs to control calcium uptake, fine-tunes ER–mitochondrial communication and regulates energy metabolism via AMPK.

    • Amado Carreras-Sureda
    • , Fabián Jaña
    • , Hery Urra
    • , Sylvere Durand
    • , David E. Mortenson
    • , Alfredo Sagredo
    • , Galdo Bustos
    • , Younis Hazari
    • , Eva Ramos-Fernández
    • , Maria L. Sassano
    • , Philippe Pihán
    • , Alexander R. van Vliet
    • , Matías González-Quiroz
    • , Angie K. Torres
    • , Cheril Tapia-Rojas
    • , Martijn Kerkhofs
    • , Rubén Vicente
    • , Randal J. Kaufman
    • , Nibaldo C. Inestrosa
    • , Christian Gonzalez-Billault
    • , R. Luke Wiseman
    • , Patrizia Agostinis
    • , Geert Bultynck
    • , Felipe A. Court
    • , Guido Kroemer
    • , J. César Cárdenas
    •  & Claudio Hetz
  • Research | | open

    Polycystin-2 (PC2) is an ion channel commonly found mutated in autosomal dominant polycystic kidney disease. Here Arhatte et al. identify transmembrane protein 33 (TMEM33) as a regulator of PC2 function at the endoplasmic reticulum, and find that deletion of TMEM33 protects mice from acute kidney injury.

    • Malika Arhatte
    • , Gihan S. Gunaratne
    • , Charbel El Boustany
    • , Ivana Y. Kuo
    • , Céline Moro
    • , Fabrice Duprat
    • , Magali Plaisant
    • , Hélène Duval
    • , Dahui Li
    • , Nicolas Picard
    • , Anais Couvreux
    • , Christophe Duranton
    • , Isabelle Rubera
    • , Sophie Pagnotta
    • , Sandra Lacas-Gervais
    • , Barbara E. Ehrlich
    • , Jonathan S. Marchant
    • , Aaron M. Savage
    • , Fredericus J. M. van Eeden
    • , Robert N. Wilkinson
    • , Sophie Demolombe
    • , Eric Honoré
    •  & Amanda Patel
  • Research | | open

    ORAI1 constitutes the store-operated Ca2+ release-activated Ca2+ (CRAC) channel, but how this channel is turned off through Ca2+-dependent inactivation (CDI) remained unclear. Here the authors identify a spatially-restricted Ca2+/cAMP signaling crosstalk critical for mediating CDI which in turn regulates cellular Ca2+ signals and NFAT activation.

    • Xuexin Zhang
    • , Trayambak Pathak
    • , Ryan Yoast
    • , Scott Emrich
    • , Ping Xin
    • , Robert M. Nwokonko
    • , Martin Johnson
    • , Shilan Wu
    • , Céline Delierneux
    • , Maxime Gueguinou
    • , Nadine Hempel
    • , James W. Putney Jr.
    • , Donald L. Gill
    •  & Mohamed Trebak
  • Research | | open

    Lysosomes are the key digestive organelles of differentiated keratinocytes in the epidermis. Mahanty et al. show that ER stress but not mTOR-MiT/TFE factors promotes lysosome biogenesis during keratinocyte differentiation, which is critical for epidermal homeostasis.

    • Sarmistha Mahanty
    • , Shruthi Shirur Dakappa
    • , Rezwan Shariff
    • , Saloni Patel
    • , Mruthyunjaya Mathapathi Swamy
    • , Amitabha Majumdar
    •  & Subba Rao Gangi Setty
  • Research | | open

    Cheng Luan et al. report that the voltage-gated calcium channel CaVγ4 is necessary for maintaining pancreatic beta-cell function. They find that MafA, a transcription factor required for beta-cell maturation, directly regulates the gene encoding CaVγ4 and suggest that restoration of CaVγ4 may be a potential treatment for type 2 diabetes.

    • Cheng Luan
    • , Yingying Ye
    • , Tania Singh
    • , Mohammad Barghouth
    • , Lena Eliasson
    • , Isabella Artner
    • , Enming Zhang
    •  & Erik Renström

News and Comment

  • News and Views |

    IRE1α is an endoplasmic reticulum (ER) transmembrane protein known for a crucial role in regulating the unfolding protein response. A study now shows that IRE1α interacts with the main ER Ca2+ channel InsP3Rs and facilitates the transfer of Ca2+ from the ER into mitochondria, thus driving cellular metabolism.

    • Roland Malli
    •  & Wolfgang F. Graier
  • Research Highlights |

    Doreen Cantrell describes a 2005 paper by Graham Hardie and colleagues showing that Ca2+–calmodulin-dependent protein kinase kinases could phosphorylate and activate AMPK, which suggested a biochemical link between T cell receptor signalling and ATP production.

    • Doreen A. Cantrell
  • Research Highlights |

    Stefan Feske and colleagues show that calcium signalling in TH17 cells promotes a pathogenic phenotype by regulating mitochondrial function and the antioxidant response.

    • Kirsty Minton
  • Research Highlights |

    Wang et al. demonstrate that increased flux of calcium derived from osteogenic cells into cancer cells promotes early-stage bone colonization. Calcium signalling in cancer cells can be targeted by arsenic trioxide, thereby reducing bone metastasis progression.

    • Ulrike Harjes