Caenorhabditis elegans

Caenorhabditis elegans is a species of soil-dwelling nematode (roundworm) used as a model organism in molecular genetics and developmental biology. It is predominantly hermaphroditic (can self-fertilize) and it is transparent, allowing the position and fate of every cell in the body to be mapped.

Latest Research and Reviews

News and Comment

  • News & Views |

    In Caenorhabditis elegans, RNAi-initiated gene silencing can persist for multiple generations. A study shows that this heritable silencing requires parallel contributions of both a nuclear transcriptional silencing pathway and perinuclear condensate-localized poly(UG)-tailed transcripts to produce abundant germline siRNAs in adult progeny.

    • Nicole M. Bush
    •  & Craig P. Hunter
    Nature Cell Biology 24, 1016-1018
  • News & Views |

    Epigenetic inheritance is the transfer of non-DNA information across generations. A new study identifies sperm-specific PEI granules as essential for paternal epigenetic inheritance. PEI granule partitioning to sperm requires palmitoylation and myosin VI activity, suggesting lipidation-dependent granule transport on vesicles.

    • Laura Thomas
    •  & Geraldine Seydoux
    Nature Cell Biology 24, 129-130
  • Research Highlights |

    The assembly of polymers can be genetically targeted to specific neurons or other cells to manipulate their properties.

    • Nina Vogt
    Nature Methods 17, 458