Cadherins articles within Nature Communications

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  • Article
    | Open Access

    The presence of CD8+ T cells in the cytoplasm of biliary epithelial cells (BEC) has been associated with primary biliary cholangitis. Here, the authors demonstrate that CD8+ T cells invade BEC using a mechanism that is dependent on cytoskeletal rearrangements and E-cadherin:β-catenin interactions.

    • Scott P. Davies
    • , Vincenzo Ronca
    •  & Ye H. Oo

  • Article
    | Open Access

    Tools for high spatiotemporal control of cell-cell adhesions are lacking. Here, authors propose an optogenetic tool, opto-E-cadherin, that allows reversible control of E-cadherin-mediated cell-cell adhesions with blue light.

    • Brice Nzigou Mombo
    • , Brent M. Bijonowski
    •  & Seraphine V. Wegner

  • Article
    | Open Access

    Adopting a round cell morphology before mitosis is crucial. Here, the authors show that in mitosis integrins binding to ligands do not engage the actomyosin cortex, which curbs cell-extracellular matrix adhesion, though β1 integrins are rewired to synergize with cadherins in mitotic cell-cell adhesion.

    • Maximilian Huber
    • , Javier Casares-Arias
    •  & Nico Strohmeyer

  • Article
    | Open Access

    Fat and Dachsous are large cadherins that regulate planar polarity as a receptor:ligand pair. Here, authors determine the structure of the Fat:Dachsous complex to uncover the molecular determinants of binding and posttranslational modification.

    • Elliot Medina
    • , Yathreb Easa
    •  & Vincent C. Luca

  • Article
    | Open Access

    How intrinsic cell properties such as stiffness contribute to cell-cell junction stabilization is not well described. Here they show that higher levels of intrinsic cell mechanics at the cortex, cytoskeleton and nucleus of neighboring cells promote junctional maturation.

    • K. Sri-Ranjan
    • , J. L. Sanchez-Alonso
    •  & Vania M. M. Braga

  • Article
    | Open Access

    In this study, the authors report that anionic nanoplastics can harness the paracellular space of endothelial cells and puncture blood vasculature ex vivo and in vivo, thereby entailing new environmental and health implications.

    • Wei Wei
    • , Yuhuan Li
    •  & Pu Chun Ke

  • Article
    | Open Access

    Actin and myosin operate at cell–cell junctions during junctional shortening. Here the authors show that prolonged actomyosin contractility can compromise junctional shortening, and that Pak3 is required for attenuation of abnormal active protrusive structure and thus keeps junction contraction, appropriate E-cadherin distribution, and junction shortening in Drosophila.

    • Hiroyuki Uechi
    • , Kazuki Fukushima
    •  & Erina Kuranaga

  • Article
    | Open Access

    Communication between endothelial leader and follower cells during collective cell migration is crucial for vascular development. Here, the authors show that PACSIN2 guides collective cell migration and angiogenesis by recruiting a protein trafficking complex to asymmetric cell-cell junctions, controlling local junction plasticity.

    • Tsveta S. Malinova
    • , Ana Angulo-Urarte
    •  & Stephan Huveneers

  • Article
    | Open Access

    Extensive scars develop in deep wounds as opposed to superficial wounds but it is unclear why. Here, the authors use live imaging of physiologic wounds and scars formed ex vivo to show that fascia fibroblasts upregulate N-cadherin allowing coordinated cell migration that drives extensive scar formation of deep wounds.

    • Dongsheng Jiang
    • , Simon Christ
    •  & Yuval Rinkevich

  • Article
    | Open Access

    Mechanical forces play a crucial role during morphogenesis, but how these are sensed and transduced in vivo is not fully understood. Here the authors apply a FRET tension sensor to live zebrafish and study changes in VE-cadherin tension at endothelial cell-cell junctions during arterial maturation.

    • Anne Karine Lagendijk
    • , Guillermo A. Gomez
    •  & Benjamin M. Hogan

  • Article
    | Open Access

    Cell–cell adhesion and oriented cell division play key roles in tissue architecture, but how they are coordinated is not known. Here, the authors show that E-cadherin interacts with LGN, and thereby provides a cortical cue that serves to stabilize cortical attachment of astral microtubules at cell–cell adhesions, thus orienting the mitotic spindle.

    • Martijn Gloerich
    • , Julie M. Bianchini
    •  & W. James Nelson

  • Article
    | Open Access

    Formation and reinforcement of E-cadherin-mediated adhesion depends on intracellular trafficking and interactions with the actin cytoskeleton, but how these are coordinated is not known. Here the authors conduct a focused phenotypic screen to identify new pathways regulating cell–cell junction homeostasis.

    • J. C. Erasmus
    • , S. Bruche
    •  & V. M. M. Braga

  • Article
    | Open Access

    Cell-cell adhesion of endothelial tissue, mediated by the adhesion molecule VE-cadherin, is tightly regulated. Here the authors show that the F-BAR domain protein pacsin2 is recruited to the trailing end of mechanically unbalanced Focal Adherens Junctions, where it inhibits internalization of VE-cadherin and protects cell-cell adhesion.

    • Yvonne L. Dorland
    • , Tsveta S. Malinova
    •  & Stephan Huveneers

  • Article
    | Open Access

    How the shape of the sternum is regulated is unclear. Here, the authors identify the Dchs1-Fat4-planar cell polarity pathway as controlling cell orientation and cell intercalation of mesenchymal cells that form skeletal condensations for the mouse sternum, which defines the relative dimensions of the sternum.

    • Yaopan Mao
    • , Anna Kuta
    •  & Philippa Francis-West

  • Article
    | Open Access

    E-cadherin is an adhesion molecule mediating cell-cell adhesion; correct localization is important but how localization is controlled is not clear. Here the authors use Drosophilaas a model system to distinguish three distinct trafficking pathways that direct E-cadherin to the zonula adherens.

    • Innokenty Woichansky
    • , Carlo Antonio Beretta
    •  & Veit Riechmann

  • Article
    | Open Access

    Cadherins are typically involved in cell-cell adhesion, however cadherin-11 promotes cell migration through an undefined mechanism. Langhe et al.show that cadherin-11 mediates adhesion to the cell matrix at focal adhesions through interaction with syndecan-4.

    • Rahul P. Langhe
    • , Tetyana Gudzenko
    •  & Jubin Kashef

  • Article |

    Angiogenesis is regulated by dynamic changes in endothelial cell contact. Here, the authors show that signals from endothelial cell junctions affect the subcellular localization and function of Yes-associated protein, ultimately modifying angiopoietin-2 expression and angiogenic activity of endothelial cells.

    • Hyun-Jung Choi
    • , Haiying Zhang
    •  & Young-Guen Kwon

  • Article |

    The role of integrin β1 in angiogenesis is poorly understood. Here, the authors show that integrin β1 regulates murine angiogenesis and adherens junction integrity by controlling VE-cadherin localization, myosin light chain phosphorylation and the function of the Rap1/MRCK and Rho/Rho-kinase pathways.

    • Hiroyuki Yamamoto
    • , Manuel Ehling
    •  & Ralf H. Adams

  • Article |

    Cadherins are calcium-dependent adhesion molecules that can form catch bonds, characterized by longer lifetimes at higher force. Here, Manibog et al. determine the mechanism of catch bond formation, whereby tension induces hydrogen bond formation between opposing extracellular domains in a calcium-dependent manner.

    • Kristine Manibog
    • , Hui Li
    •  & Sanjeevi Sivasankar

  • Article |

    Cell–cell adhesion molecules and the cytoskeleton determine endothelial cell shape during the formation of blood vessels. Here the authors show that the scaffold protein, amotL2, couples adherens junctions to contractile cytoskeletal proteins to coordinate cellular morphogenesis with aortic lumen expansion.

    • Sara Hultin
    • , Yujuan Zheng
    •  & Lars Holmgren

  • Article
    | Open Access

    Vascular endothelial-cadherin is a junctional protein implicated in the control of vascular permeability. Orsenigo et al.find that vascular endothelial-cadherin is phosphorylated in veins but not in arteries of mice, and that this sensitizes vessels to rapid changes in permeability in response to inflammatory mediators.

    • Fabrizio Orsenigo
    • , Costanza Giampietro
    •  & Elisabetta Dejana

  • Article |

    Endothelial cells provide a vital barrier system to the passage of water and ions but not large plasma proteins. Using fluorescently labelled dextrans, the authors show that regions of high or low adherens junction density differentially restrict the passage of molecules up to 70 kDa in size.

    • Sadiqa K. Quadri
    • , Li Sun
    •  & Jahar Bhattacharya

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