Bone marrow transplantation articles within Nature Communications

Featured

• Article
  02 January 2024 | Open Access

  Integrative genotyping of cancer and immune phenotypes by long-read sequencing

  Single-cell transcriptomics excel in cell subset classification and can be augmented by suitable genotype information. Here the authors devise a long-read sequencing workflow, termed nanoranger, for detection of molecular barcodes from single-cell cDNA and apply this to clonal tracking of acute myeloid leukemia and identification of complex immune phenotypes.

  • Livius Penter
  • , Mehdi Borji
  •  & Catherine J. Wu

• Article
  31 October 2023 | Open Access

  Antigen presentation by B cells enables epitope spreading across an MHC barrier

  Increasing evidence suggests that antigen presentation by B cells is critical to the initiation of autoimmunity. Here, the authors demonstrate that tolerance breakdown is initiated outside of germinal centres and that B cells can directly instruct T cells to break tolerance and propagate autoimmune responses.

  • Cecilia Fahlquist-Hagert
  • , Thomas R. Wittenborn
  •  & Søren E. Degn

• Article
  06 July 2021 | Open Access

  Inflammatory monocytes promote pre-engraftment syndrome and tocilizumab can therapeutically limit pathology in patients

  Pre-engraftment syndrome is a major consideration during clinical application of unrelated cord blood transfusion and monocytes represent a critical cell type in immune-pathogenesis. Here the authors further establish the role of monocytes and GM-CSF in pre-engraftment syndrome and show clinical administration of tocilizumab limits pathology in pre-engraftment syndrome pathology in patients.

  • Linlin Jin
  • , Zimin Sun
  •  & Haiming Wei

• Article
  11 June 2021 | Open Access

  Non-conditioned bone marrow chimeric mouse generation using culture-based enrichment of hematopoietic stem and progenitor cells

  Bone marrow chimaeric mice are a valuable tool in research, but require myeloablative conditioning. Here the authors demonstrate efficient FACS-free enrichment of haematopoietic stem and progenitor cells for transplantation into unconditioned recipient mice, as well as for genetic engineering using polyvinyl alcohol based media.

  • Kiyosumi Ochi
  • , Maiko Morita
  •  & Satoshi Yamazaki

• Article
  05 February 2021 | Open Access

  IL-22-dependent dysbiosis and mononuclear phagocyte depletion contribute to steroid-resistant gut graft-versus-host disease in mice

  Pathogenesis of steroid-resistant gut acute graft-versus-host-disease (SR-Gut-aGVHD) remains unclear., Here the authors show in mouse models that dysbiosis caused by the expansion of Th/Tc22, as well as depletion of CX3CR1^hi mononuclear phagocytes resulted from the reduction of Th/Tc1, contributes to SR-Gut-aGVHD onset.

  • Qingxiao Song
  • , Xiaoning Wang
  •  & Defu Zeng

• Article
  03 April 2020 | Open Access

  Oncogenic Kras^G12D causes myeloproliferation via NLRP3 inflammasome activation

  Oncogenic Ras mutations are common drivers in myeloid leukemia. Here, the authors show in patient cells and in mice that oncogenic K-Ras activates NLRP3 inflammasome to drive myeloproliferation, which can be reversed by genetic or pharmacologic NLRP3 blockade.

  • Shaima’a Hamarsheh
  • , Lena Osswald
  •  & Robert Zeiser

• Article
  06 September 2019 | Open Access

  Caspase-11 signaling enhances graft-versus-host disease

  An increasing number of inflammatory pathologies is associated with IL-1 production downstream of caspases 1 and 11. Here the authors show that graft-versus-host-disease (GvHD) is diminished in mice with genetic or pharmacological ablation of caspase-11, and provide mechanistic insights into the signals leading to caspase-11 activation in GvHD.

  • Yanyan Lu
  • , Ran Meng
  •  & Ben Lu

• Article
  02 August 2019 | Open Access

  Phc2 controls hematopoietic stem and progenitor cell mobilization from bone marrow by repressing Vcam1 expression

  Mobilization of hematopoietic stem and progenitor cells (HSPCs) into the circulation is essential for maintaining homeostasis. Here, the authors show that Phc2 in bone marrow stromal cells represses the cell adhesion molecule Vcam1 and facilitates mobilization of HSPCs through regulation of epigenetic marks.

  • Joonbeom Bae
  • , Sang-Pil Choi
  •  & Taehoon Chun

• Article
  06 February 2019 | Open Access

  Hematopoietic chimerism and donor-specific skin allograft tolerance after non-genotoxic CD117 antibody-drug-conjugate conditioning in MHC-mismatched allotransplantation

  Transplantation of allogeneic bone marrow helps establish chimerism that may induce tolerance to tissue grafts. Here the authors show that a CD117-antibody-drug-conjugate helps precondition the recipients for inducing mixed chimerism and allo-tolerance without clear adverse effects or the need for chronic immune suppression.

  • Zhanzhuo Li
  • , Agnieszka Czechowicz
  •  & Philip M. Murphy

• Article
  06 February 2019 | Open Access

  Selective hematopoietic stem cell ablation using CD117-antibody-drug-conjugates enables safe and effective transplantation with immunity preservation

  Hematopoietic stem cell (HSC) transplantation is a desirable treatment for many non-malignant and malignant diseases, but its use requires preconditioning of recipients with irradiation or chemotherapy that often induces high toxicity. Here the authors show that antibody-drug-conjugate to CD117, a HSC marker, allows specific and efficient preconditioning for HSC therapy.

  • Agnieszka Czechowicz
  • , Rahul Palchaudhuri
  •  & Derrick J. Rossi

• Article
  06 December 2018 | Open Access

  Engrafted parenchymal brain macrophages differ from microglia in transcriptome, chromatin landscape and response to challenge

  Irradiation depletes brain microglia cells and induces replenishment of the pool by bone marrow (BM)-derived macrophage. Here the authors show, using mouse BM chimera, that BM-derived macrophages establish long-term residency in the brain, but remain distinct from resident microglia in their transcriptome and gene accessibility landscape.

  • Anat Shemer
  • , Jonathan Grozovski
  •  & Steffen Jung

• Article
  25 October 2018 | Open Access

  Evidence for persistence of the SHIV reservoir early after MHC haploidentical hematopoietic stem cell transplantation

  Allogeneic hematopoietic cell transplantation (allo-HCT) has led to the cure of HIV in one individual, but the underlying mechanisms are unclear. Here, the authors present a model of allo-HCT in SHIV-infected nonhuman primates and show that the SHIV reservoir persists in multiple tissues early after transplantation.

  • Lucrezia Colonna
  • , Christopher W. Peterson
  •  & Leslie S. Kean

• Article
  10 September 2018 | Open Access

  Microbial metabolite sensor GPR43 controls severity of experimental GVHD

  The microbial metabolite sensor GPR43 has been previously shown to be a crucial modulator of immune responses. Here the authors show GPR43 is required for controlling disease pathology severity in the context of experimental models of GVHD.

  • Hideaki Fujiwara
  • , Melissa D. Docampo
  •  & Pavan Reddy

• Article
  15 January 2018 | Open Access

  Escape from thymic deletion and anti-leukemic effects of T cells specific for hematopoietic cell-restricted antigen

  Antigen distribution patterns affect thymic negative selection. Here, the authors show that incomplete thymic negative selection occurs to T cells for hematopoietic cell-restricted antigen H60 in mice, driving graft-versus-leukemia after H60-mismatched bone marrow transplantation.

  • Ji-Min Ju
  • , Min Ho Jung
  •  & Eun Young Choi

• Article
  17 October 2017 | Open Access

  Extrafollicular CD4⁺ T-B interactions are sufficient for inducing autoimmune-like chronic graft-versus-host disease

  Chronic graft-versus-host disease (cGVHD) is mediated by specific CD4 and B cells, but the relative contribution of extrafollicular and germinal centre (GC) T-B interaction is unclear. Here the authors show that the extrafollicular expansion of a specific CD4 T subset is sufficient for inducing cGVHD while GC is dispensable.

  • Ruishu Deng
  • , Christian Hurtz
  •  & Defu Zeng

• Article
  09 May 2017 | Open Access

  Foxp3⁺ regulatory T cells maintain the bone marrow microenvironment for B cell lymphopoiesis

  Treg cells suppress peripheral immune responses, but their function in haematopoiesis is unclear. Here the authors show they modulate the bone marrow microenvironment to sustain haematopoietic stem cell-driven generation of mature B cells.

  • Antonio Pierini
  • , Hidekazu Nishikii
  •  & Robert S. Negrin

• Article | 14 October 2015

  Sleep disruption impairs haematopoietic stem cell transplantation in mice

  How can you increase the success of hematopoietic stem cell (HSC) transplantation? In mice, Rolls et al. identify sleep in the donor as an important factor, finding that less sleep leads to 50% lower HSC engraftment, via miR-19b and suppressor of cytokine signaling genes, which prevent HSC homing.

  • Asya Rolls
  • , Wendy W. Pang
  •  & Luis de Lecea