Bone marrow cells

Culturing bone marrow stromal cells on 3D silk scaffolds supports their proliferation and adipogenesis, while minimizing the activation of inflammatory pathways. Therefore, differentiation of bone marrow adipocytes in 3D culture might provide a more representative model for the study of bone marrow adipose tissue than is offered by traditional 2D cell cultures.

Causing nanoscale vibrations in bone-marrow stromal cells embedded in a soft collagen gel induces the cells to undergo osteogenic differentiation and mineralization via mechanosensitive signalling pathways.

A population of immature myeloid cells in the bone marrow can transfer proteinuric kidney disease from affected to unaffected mice. This new finding highlights a possible central role of bone marrow as the source of the circulating factor(s) that lead to recurrent focal segmental glomerulosclerosis and potentially other kidney diseases.