Bone development articles from across Nature Portfolio

Bone development is the formation and growth of bones. New bone is formed by the action of specialised cells called osteoblasts and osteoclasts, either by directly laying down bone tissue into connective tissue or forming it from cartilage, such as during growth in length of long bones.

Latest Research and Reviews

Research
14 March 2023 | Open Access

BRD9-mediated chromatin remodeling suppresses osteoclastogenesis through negative feedback mechanism

Osteoclast differentiation is critical for bone homeostasis. The authors show the negative feedback regulation of BRD9-mediated chromatin remodeling on osteoclastogenesis via interferon beta signaling and its therapeutic potential for bone diseases.
- Jiahui Du
- , Yili Liu
- & Xinquan Jiang
Nature Communications 14, 1413
Research
01 March 2023 | Open Access

Subset of the periodontal ligament expressed leptin receptor contributes to part of hard tissue-forming cells
- Hirotsugu Oka
- , Shinichirou Ito
- & Toshihide Mizoguchi
Scientific Reports 13, 3442
Research
04 January 2023 | Open Access

Inhibition of miR338 rescues cleidocranial dysplasia in Runx2 mutant mice partially via the Hif1a-Vegfa axis
- Runze Jin
- , Hanshu Zhang
- & Huan Liu
Experimental & Molecular Medicine 55, 69-80
Research
23 December 2022 | Open Access

Effect of thermal osteonecrosis around implants in the rat tibia: numerical and histomorphometric results in context of implant removal
- Kristian Kniha
- , Benita Hermanns-Sachweh
- & Ali Modabber
Scientific Reports 12, 22227
Research
21 December 2022 | Open Access

A new confuciusornithid bird with a secondary epiphyseal ossification reveals phylogenetic changes in confuciusornithid flight mode

A new species of Confuciusornis, a genus of basal birds from the Early Cretaceous, reveals that these early birds had stronger flight capability and more diverse flight modes than previously expected.
- Renfei Wang
- , Dongyu Hu
- & Xing Xu
Communications Biology 5, 1398
Research
29 November 2022 | Open Access

MiR-148a deletion protects from bone loss in physiological and estrogen-deficient mice by targeting NRP1
- Bin Pan
- , Lin Zheng
- & Dengwei He
Cell Death Discovery 8, 470

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News and Comment

News & Views | 05 September 2018

A Notch in the joint that exacerbates osteoarthritis

Tight regulation of signalling cascades is vital for the correct development and function of bones and joints. A new study suggests that Notch signalling might join the likes of the transforming growth factor superfamily and Wnt signalling cascades as having an important function in joint homeostasis and disease.
- Silvia Monteagudo
- & Rik J. Lories
Nature Reviews Rheumatology 14, 563-564
Research Highlights | 24 July 2018

Playing catch-up
- Clark Nelson
Lab Animal 47, 209
News & Views | 12 September 2017

Making bone via nanoscale kicks

Causing nanoscale vibrations in bone-marrow stromal cells embedded in a soft collagen gel induces the cells to undergo osteogenic differentiation and mineralization via mechanosensitive signalling pathways.
- Jeroen Eyckmans
- & Christopher S. Chen
Nature Biomedical Engineering 1, 689-690
Correspondence
22 August 2014 | Open Access

Osteogenic fate of hypertrophic chondrocytes
- Guan Yang
- , Liang Zhu
- & Xiao Yang
Cell Research 24, 1266-1269
Editorial | 11 August 2014

Dlx genes and the maintenance of bone homeostasis and skeletal integrity
- G Levi
- & Y Gitton
Cell Death & Differentiation 21, 1345-1346
Research Highlights | 01 October 2013

Soluble FGFR-3 as potential therapy for achondroplasia

Nature Reviews Endocrinology 9, 692

All News & Comment

Bone development articles from across Nature Portfolio

Latest Research and Reviews

BRD9-mediated chromatin remodeling suppresses osteoclastogenesis through negative feedback mechanism

Subset of the periodontal ligament expressed leptin receptor contributes to part of hard tissue-forming cells

Inhibition of miR338 rescues cleidocranial dysplasia in Runx2 mutant mice partially via the Hif1a-Vegfa axis

Effect of thermal osteonecrosis around implants in the rat tibia: numerical and histomorphometric results in context of implant removal

A new confuciusornithid bird with a secondary epiphyseal ossification reveals phylogenetic changes in confuciusornithid flight mode

MiR-148a deletion protects from bone loss in physiological and estrogen-deficient mice by targeting NRP1

News and Comment

A Notch in the joint that exacerbates osteoarthritis

Playing catch-up

Making bone via nanoscale kicks

Osteogenic fate of hypertrophic chondrocytes

Dlx genes and the maintenance of bone homeostasis and skeletal integrity

Soluble FGFR-3 as potential therapy for achondroplasia

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