Blood–brain barrier articles within Nature

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  • Article |

    Studies in a mouse model of neurolisteriosis show that the effector protein InlB produced by Listeria monocytogenes protects infected monocytes in the host from T cell-mediated cell death, and thereby increases bacterial neuroinvasion, persistence and transmission.

    • Claire Maudet
    • , Marouane Kheloufi
    •  & Marc Lecuit

  • Article |

    A study describes single-cell characterization of the human cerebrovasculature, revealing human-specific transcriptomic signatures and providing insights into transcriptional changes associated with Huntington’s disease.

    • Francisco J. Garcia
    • , Na Sun
    •  & Myriam Heiman

  • Article |

    Caveolae in arteriolar endothelial cells—but not those in neighbouring smooth muscle cells—have a key role in neurovascular coupling, an essential function for meeting acute brain energy demand.

    • Brian W. Chow
    • , Vicente Nuñez
    •  & Chenghua Gu

  • Article |

    Single-cell transcriptomic analysis of the murine blood–brain barrier provides molecular definitions of the main vascular cell types, classifies perivascular cell types and sheds light on the organization of the arteriovenous axis.

    • Michael Vanlandewijck
    • , Liqun He
    •  & Christer Betsholtz

  • Letter |

    Mfsd2a is a key regulator of blood–brain barrier (BBB) formation and function in mice: Mfsd2a is selectively expressed in BBB-containing blood vessels in the CNS; Mfsd2a−/− mice have a leaky BBB and increased vesicular transcytosis in CNS endothelial cells; and Mfsd2a endothelial expression is regulated by pericytes to facilitate BBB integrity.

    • Ayal Ben-Zvi
    • , Baptiste Lacoste
    •  & Chenghua Gu

  • Letter |

    A Lewis rat model of experimental autoimmune encephalomyelitis is used to show that on their way to the CNS, encephalitogenic T-cell blasts are temporarily resident in the lung, where they reprogram their gene-expression profile and functional properties to enable them to transgress the blood–brain barrier into the CNS.

    • Francesca Odoardi
    • , Christopher Sie
    •  & Alexander Flügel

  • News & Views |

    Alterations in brain blood vessels in mice precede the neural dysfunction associated with Alzheimer's disease. The finding highlights potential targets for drug development. See Letter p.512

    • Peter Carmeliet
    •  & Bart De Strooper

  • Letter |

    The blood–brain barrier (BBB) is made up of vascular endothelial cells and was thought to have formed postnatally from astrocytes. Two independent studies demonstrate that this barrier forms during embryogenesis, with pericyte/endothelial cell interactions being critical to regulate the BBB during development. A better understanding of the relationship among pericytes, neuroendothelial cells and astrocytes in BBB function will contribute to our understanding of BBB breakdown during central nervous system injury and disease.

    • Annika Armulik
    • , Guillem Genové
    •  & Christer Betsholtz

  • Letter |

    The blood–brain barrier (BBB) is made up of vascular endothelial cells and was thought to have formed postnatally from astrocytes. Two independent studies demonstrate that this barrier forms during embryogenesis, with pericyte/endothelial cell interactions being critical to regulate the BBB during development. A better understanding of the relationship among pericytes, neuroendothelial cells and astrocytes in BBB function will contribute to our understanding of BBB breakdown during central nervous system injury and disease.

    • Richard Daneman
    • , Lu Zhou
    •  & Ben A. Barres

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