Bladder disease articles from across Nature Portfolio

The diurnal rhythm of glucocorticoid is shown to be a master regulator of the bladder clock in mice.

Diabetic bladder dysfunction (DBD) is a common complication of diabetes. Hyperglycaemia-induced oxidative stress is thought to mediate functional changes in organs and tissues affected by DBD. In this Review, the authors provide an overview of mechanisms and consequences of oxidative stress, focusing on the role of diabetes-induced oxidative stress in generating dysfunctions at the level of the urothelium, smooth muscle contractility and nerve structures involved in DBD pathogenesis.

The use of optogenetic strategies in biomedicine therapeutics has the potential to provide nonpharmacological modulation of nervous system function. The development of integrative, implantable, remote-powered devices is an advance towards translation of these strategies, with the potential for precision, revolutionary treatment of complex or refractory disease-related or trauma-related symptoms.

In clinical studies, mirabegron has been shown to cause a small increase in heart rate with a slight increase in QTc interval, as indicated on electrocardiograms. The mechanisms of these effects are unclear. The findings of a recent study might provide some new clues, although, the relevance of these new observations to the treatment of patients with overactive bladder syndrome have yet to be established.