Bipolar disorder articles from across Nature Portfolio

Whether temporal variations in brain MRI metrics can be attributed to circadian or diurnal oscillations is unclear. Here, the authors show evidence for diurnal oscillations in MRI metrics in both healthy controls and participants with bipolar disorder.

By developing the large-scale cortical spatial–rhythmic network analysis, authors identify putative electrophysiological biomarkers for clinical screening of individuals at high familial risk of bipolar disorder onset.

A trial comparing long-term versus short-term antidepressant maintenance therapy fails to show a significant benefit of continued treatment.

Human and animal studies reveal a neurobiological pathway that connects polygenic risks and behavioural changes that are shared between schizophrenia and bipolar mood disorder.