Biotechnology

Definition

Biotechnology is a broad discipline in which biological processes, organisms, cells or cellular components are exploited to develop new technologies. New tools and products developed by biotechnologists are useful in research, agriculture, industry and the clinic.

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Latest Research and Reviews

  • Research |

    The development of selective ubiquitin-specific protease-7 (USP7) inhibitors GNE-6640 and GNE-6776, which induce tumour cell death and reveal differential kinetics of Lys-48 and Lys-63-linked ubiquitin chain depolymerization by USP7.

    • Lorna Kategaya
    • , Paola Di Lello
    • , Lionel Rougé
    • , Richard Pastor
    • , Kevin R. Clark
    • , Jason Drummond
    • , Tracy Kleinheinz
    • , Eva Lin
    • , John-Paul Upton
    • , Sumit Prakash
    • , Johanna Heideker
    • , Mark McCleland
    • , Maria Stella Ritorto
    • , Dario R. Alessi
    • , Matthias Trost
    • , Travis W. Bainbridge
    • , Michael C. M. Kwok
    • , Taylur P. Ma
    • , Zachary Stiffler
    • , Bradley Brasher
    • , Yinyan Tang
    • , Priyadarshini Jaishankar
    • , Brian R. Hearn
    • , Adam R. Renslo
    • , Michelle R. Arkin
    • , Frederick Cohen
    • , Kebing Yu
    • , Frank Peale
    • , Florian Gnad
    • , Matthew T. Chang
    • , Christiaan Klijn
    • , Elizabeth Blackwood
    • , Scott E. Martin
    • , William F. Forrest
    • , James A. Ernst
    • , Chudi Ndubaku
    • , Xiaojing Wang
    • , Maureen H. Beresini
    • , Vickie Tsui
    • , Carsten Schwerdtfeger
    • , Robert A. Blake
    • , Jeremy Murray
    • , Till Maurer
    •  & Ingrid E. Wertz
  • Research | | open

    Controlled fabrication of few-atoms supported catalysts is a major challenge in the synthesis of nanomaterials. Here, the authors show a bottom-up approach to precisely synthesize platinum dimers supported on graphene, which display higher catalytic activity and stability than single atoms and nanoparticles.

    • Huan Yan
    • , Yue Lin
    • , Hong Wu
    • , Wenhua Zhang
    • , Zhihu Sun
    • , Hao Cheng
    • , Wei Liu
    • , Chunlei Wang
    • , Junjie Li
    • , Xiaohui Huang
    • , Tao Yao
    • , Jinlong Yang
    • , Shiqiang Wei
    •  & Junling Lu
  • Research | | open

    Grain boundaries are thought to significantly mediate phase transformations in nanoparticles. Here, the authors combine multichannel plasmonic nanospectroscopy and transmission Kikuchi diffraction to study the role of grain boundaries in hydriding reactions of Pd nanoparticles on a single-particle level.

    • Svetlana Alekseeva
    • , Alice Bastos da Silva Fanta
    • , Beniamino Iandolo
    • , Tomasz J. Antosiewicz
    • , Ferry Anggoro Ardy Nugroho
    • , Jakob B. Wagner
    • , Andrew Burrows
    • , Vladimir P. Zhdanov
    •  & Christoph Langhammer
  • Research | | open

    Upconversion nanoparticles, which do not suffer from the photophysical artifacts that limit fluorescent molecules, offer an exciting opportunity for biological super-resolution imaging. Here, Zhan et al. develop an efficient STED mechanism using optimized lanthanide upconversion nanoparticles, enabling cytoskeleton nanoscopic imaging.

    • Qiuqiang Zhan
    • , Haichun Liu
    • , Baoju Wang
    • , Qiusheng Wu
    • , Rui Pu
    • , Chao Zhou
    • , Bingru Huang
    • , Xingyun Peng
    • , Hans Ågren
    •  & Sailing He
  • Research | | open

    Torsade de Pointes (TdP) is a life-threatening ventricular arrhythmia often caused by drugs. In response to an urgent need for human tissue TdP models, here the authors describe a 3D human iPS cell-engineered heart tissue that generates TdP in response to drugs, providing a suitable model for studies of TdP mechanism and drug toxicity.

    • Masahide Kawatou
    • , Hidetoshi Masumoto
    • , Hiroyuki Fukushima
    • , Gaku Morinaga
    • , Ryuzo Sakata
    • , Takashi Ashihara
    •  & Jun K. Yamashita

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