Biotechnology articles from across Nature Portfolio

Arrhythmogenic cardiomyopathy is a major cause of sudden death among young people. Three studies show that gene therapy to restore the desmosomal protein PKP2 holds promise in improving the prognosis of affected individuals.

Deep learning shows promise for predicting gene expression levels from DNA sequences. However, recent studies show that current state-of-the-art models struggle to accurately characterize expression variation from personal genomes, limiting their usefulness in personalized medicine.

Post-infusion poly(ethylene glycol) surface modification of chimeric antigen receptor (CAR)-engineered T cells and a subcutaneous chemokine-adsorbing hydrogel address cytokine release syndrome and the neurotoxicity side effects of CAR T cell therapy against tumours.

Cultured meat technology promises to alleviate protein shortages, but still faces many challenges. Here, the authors achieve serum-free myogenic differentiation of porcine pre-gastrulation epiblast stem cells and generate meat-like tissue via edible plant-based scaffolds without any animal compounds.

Accurate diagnosis of Alzheimer’s disease in its earliest stage can prevent the disease and delay the symptoms. Here the authors identify a potential Alzheimer’s biomarker from tear fluid, and develop a nanoparticle-based immunoassay for its detection, demonstrating potential in Alzheimer’s diagnosis.

Spatial transcriptomics (ST) enables gene expression characterisation within tissue sections, but comparing across sections and technologies remains challenging. Here, authors develop STalign to spatially align ST data and demonstrate applications including aligning to common coordinate frameworks.

Genetically modified blood cells could churn out therapeutic proteins for treating inflammation and other conditions.

From drivable bionic animals to machines made from muscle, biohybrid robots are on their way to a variety of uses.

Arrhythmogenic cardiomyopathy is a major cause of sudden death among young people. Three studies show that gene therapy to restore the desmosomal protein PKP2 holds promise in improving the prognosis of affected individuals.

Developments in nanopore-based peptide detection and sequencing show promise of a breakthrough.

Spatially resolved multimodal omics offers a collective way to capture molecular information in complex tissues.

Gene therapy involving adenine base editing can correct a pathogenic variant in the Scn5a gene and alleviate arrhythmia phenotypes in a mouse model of long QT syndrome type 3.