Biotechnology articles from across Nature Portfolio

A new approach to treating mitochondrial disorders is based on the transplantation of healthy mitochondria, and improves symptoms and survival in a mouse model of Leigh syndrome — a paediatric mitochondrial disease that is characterized by failure to thrive, lactic acidosis, and progressive degeneration.

A DNA origami nanodevice presents its hidden death ligand pattern in the acidic tumour microenvironment to kill cancerous cells, opening opportunities for effective and safe cancer therapy.

DNA origami tension sensors, created by integrating DNA origami sheets with molecular tension probes, enable the quantification of mechanical forces involved in T cell receptor interactions at intermembrane junctions.

Deep vein thrombosis after trauma (pt-DVT) patients undergo metabolic changes but a comprehensive characterization in humans is lacking. Here the authors integrate metabolome and proteome to reveal pt-DVT-related metabolic alterations and their function, and reveal potential biomarkers.

Optical nanoprobes with preferential tumour accumulation is often limited by inefficient amplification of biological signals. Here, the authors report a hydrophobic core-tunable nanoprobe orthogonally amplifying tumour microenvironmental signals and demonstrating clear delineation between malignant lesions and normal tissues on multiple tumour models.

The authors propose a framework to be followed during preclinical investigation of nanomedicines to increase their translatability potential.

An article in Nature Electronics reports the development of a biodegradable, minimally invasive tent electrode for large-area cortex monitoring.

An article in Nature Materials reports a new method for generating macroscale living materials by using cells as active crosslinkers.

A new approach to treating mitochondrial disorders is based on the transplantation of healthy mitochondria, and improves symptoms and survival in a mouse model of Leigh syndrome — a paediatric mitochondrial disease that is characterized by failure to thrive, lactic acidosis, and progressive degeneration.

In this Tools of the Trade article, Mayar Allam and Ahmet Coskun describe how they combined spatial metabolomics and proteomics profiling — in a framework they call scSpaMet — to explore, at the single-cell level, how metabolic profiles vary by location and in disease.

A DNA origami nanodevice presents its hidden death ligand pattern in the acidic tumour microenvironment to kill cancerous cells, opening opportunities for effective and safe cancer therapy.