Biotechnology articles from across Nature Portfolio

Arrhythmogenic cardiomyopathy is a major cause of sudden death among young people. Three studies show that gene therapy to restore the desmosomal protein PKP2 holds promise in improving the prognosis of affected individuals.

Deep learning shows promise for predicting gene expression levels from DNA sequences. However, recent studies show that current state-of-the-art models struggle to accurately characterize expression variation from personal genomes, limiting their usefulness in personalized medicine.

Post-infusion poly(ethylene glycol) surface modification of chimeric antigen receptor (CAR)-engineered T cells and a subcutaneous chemokine-adsorbing hydrogel address cytokine release syndrome and the neurotoxicity side effects of CAR T cell therapy against tumours.

The composition of lipid nanoparticles for the delivery of tumour-antigen-encoding mRNA can be optimized via a screening method to enhance antitumour activity via the modulation of the immune activity of helper T cells.

Beyond in vivo models, stem cell-based in vitro models and theoretical models of morphogenesis have been constructed to recapitulate morphogenetic events during embryo development with heightened quantitative specificity. This Review discusses the accomplishments, challenges and opportunities of these models in promoting knowledge of mammalian development, including human development.

Using hydrogel nanovials to capture single mesenchymal stromal cells and their growth factor secretions, the authors link cell secretion to the transcriptome for thousands of cells, SEC-seq, enabling the study of secretion-associated cell states and mechanisms in therapeutic cell types.

Genetically modified blood cells could churn out therapeutic proteins for treating inflammation and other conditions.

From drivable bionic animals to machines made from muscle, biohybrid robots are on their way to a variety of uses.

Arrhythmogenic cardiomyopathy is a major cause of sudden death among young people. Three studies show that gene therapy to restore the desmosomal protein PKP2 holds promise in improving the prognosis of affected individuals.

Developments in nanopore-based peptide detection and sequencing show promise of a breakthrough.

Spatially resolved multimodal omics offers a collective way to capture molecular information in complex tissues.

Gene therapy involving adenine base editing can correct a pathogenic variant in the Scn5a gene and alleviate arrhythmia phenotypes in a mouse model of long QT syndrome type 3.