Biostatistics articles from across Nature Portfolio

The use of a standardized outcome metric enhances clinical trial interpretation and cross-trial comparison. Here, the authors show the implementation of such a metric using type 1 diabetes trial data, reassess and compare results from these trials, and extend its use to define response to therapy.

The complex transmission chain of tuberculosis (TB) forces mathematical modelers to make mechanistic assumptions when modelling vaccine effects. Here, authors posit a Bayesian formalism that unlocks mechanism-agnostic impact forecasts for TB vaccines.