Biosensors articles from across Nature Portfolio

NanoLuciferase- and HaloTag-based screening technologies are versatile tools suitable for the live-cell analysis of the entire small-molecule-induced degradation cascade to uncover the mode of action of proximity-inducing compounds such as PROTACs.

The recent monkeypox outbreak highlighted the need for rapid and accurate diagnosis of this disease. Here, authors develop an ultrasensitive and streamlined CRISPR assay using miniaturized device, which can detect monkeypox virus in rash fluid swab, oral swab, saliva, and urine within 15 minutes.

A key aspect of wearable devices used in personal health monitoring are the electrodes that make contact with the skin. This Review discusses how the materials and structure of electrodes used in these devices are vital to their performance, including how altering these factors might optimize their function.

Despite the enormous progress in the field of giant lipid vesicles, their use for in vivo biomedical applications is limited. Here, the authors discuss red blood cells as inspiration for enhancing those vesicles, investigating the required cellular features and the corresponding technical hurdles.

The strong scattering of biological tissue causes challenges when monitoring temperature changes at the microscale. Here, the authors propose a nanothermometer based on lanthanide luminescence, enabling minimally invasive imaging of the cerebrovascular system of mice at nearly 200 μm resolution.

Physicochemical-sensing electronic skins — combined with artificial intelligence — could be used to develop personalized stress management systems.

An aptamer-based nanobiosensor has been integrated into a wearable sweat sensor, allowing non-invasive tracking of the female reproductive hormone, oestradiol, with the potential to deliver sustainable solutions to female reproductive healthcare needs.

Wearable devices can provide personalised medicine at the point of need, potentially increasing access to health services and therefore improving health equity. Here the authors discuss their experiences developing wearable devices for vulnerable patient populations, including neonates and pregnant individuals.