Biophysical methods articles from across Nature Portfolio

A hybrid physics-informed neural network and differentiable learning algorithm integrates a recurrent neural network model of 3D continuum soft tissue with a differentiable fluid solver to infer 3D tissue dynamics from sparse 2D images.

A new instrument named OptoRheo combines light sheet fluorescence microscopy and particle tracking microrheology for live imaging and micromechanical sensing of extracellular matrix-cell interactions.

A method for the sequential assessment of the physical phenotypes of suspended cells singularized from tissue biopsies by mechanical dissociation allows for rapid diagnoses.

Line-scan Brillouin microscopy enables fast 3D imaging of mechanical properties with low phototoxicity, as shown for Drosophila and mouse embryos, as well as ascidians.

A dual line-scanning approach increases imaging speed and reduces illumination levels in Brillouin microscopy, which is demonstrated on spheroids.