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Bionanoelectronics is an interdisciplinary field concerned with systems that interface biological matter with synthetic biocompatible nanomaterials for use in electronic components. Examples of bionanoelectronic systems are biosensors, drug-delivery devices and neural circuits.
Minimal invasiveness and robust signal detection are required in neural probes. Here, the authors develop NeuroWeb, an ultra-thin, minimally invasive surface electrode array. In vivo electrophysiological and optogenetic experiments show single-unit activity of neurons with high signal-to-noise ratio.
Quantum biological electron transfer has potential in diagnostic and therapeutic settings. Here the authors report the triggered apoptosis of cancer cells using electricical input to wirelessly induce redox interactions at bio-nanoantennae in proximity to cancer cells.
Intrinsically disordered proteins (IDPs) are highly dynamic and play pivotal roles in cellular processes but can be difficult to study. Here, the authors develop a single-molecule nanocircuit for the real-time monitoring of c-Myc conformational transitions and their interaction with ligands.
An article in Science reports a co-polymer with both semiconducting and adhesive properties, which can effectively stick an organic electrochemical transistor (OECT)-based sensor to living tissues.
An article in Science Advances reports a biohybrid neural interface device that integrates a cell layer on a microelectrode array, achieving high-resolution mapping of neuronal inputs and restoration of nerve function.