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Exosome-coated oxygen nanobubble-laden hydrogel augments intracellular delivery of exosomes for enhanced wound healing
Challenges including hypoxia, inflammation, and inadequate exosome intracellular delivery hinder wound healing. Here, the authors show that a multifunctional exosome-coated oxygen nanobubble-laden hydrogel enhances exosome delivery and mitigates hypoxia for enhanced wound healing.
- Xiaoxue Han
- , Chaimongkol Saengow
- & Joseph Irudayaraj
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Article
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Membrane to cortex attachment determines different mechanical phenotypes in LGR5+ and LGR5- colorectal cancer cells
The mechanical properties of heterogeneous cell populations in colorectal tumors and the relevance to cancer metastasis remain not fully understood. Here, the authors suggest that the variations in malignant phenotypes between LGR5-positive cancer stem cells and LGR5-negative cells could be due to their distinct mechanical phenotypes observed in vitro, determined by the membrane to cortex attachment proteins Ezrin/Radixin/Moesin.
- Sefora Conti
- , Valeria Venturini
- & Xavier Trepat
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Impact of PEG sensitization on the efficacy of PEG hydrogel-mediated tissue engineering
Concerns over the immunogenicity of poly(ethylene glycol) (PEG) are growing, and the implications for tissue engineering are unknown. Here the authors evaluate the impact of anti-PEG antibodies and PEG immunogenicity on the efficacy of a PEG hydrogel-based tissue engineering therapy.
- Alisa H. Isaac
- , Sarea Y. Recalde Phillips
- & Daniel L. Alge
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Engineering a synthetic gene circuit for high-performance inducible expression in mammalian systems
Inducible gene expression systems can be used to control the expression of a gene of interest by means of small molecules. Here the authors present CASwitch, a synthetic gene circuit platform enhancing inducible gene expression systems by reducing leakiness and boosting fold induction, for real world applications like gene therapy vector production and biosensors.
- Giuliano De Carluccio
- , Virginia Fusco
- & Diego di Bernardo
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Article
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Bioelectric stimulation controls tissue shape and size
Electrical stimulation of hollow, 3D kidney tissues causes these tissues to inflate and change shape. The authors call this process electro-inflation and connect it to electricity driving ions into the center of the tissues, causing water to follow by osmosis.
- Gawoon Shim
- , Isaac B. Breinyn
- & Daniel J. Cohen
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Article
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DeepDOF-SE: affordable deep-learning microscopy platform for slide-free histology
Histopathology can be limited by the time-consuming and labour-intensive preparation of slides from resected tissue. Here, the authors report DeepDOF-SE, a deep-learning-enabled microscope to rapidly scan intact tissue at cellular resolution without the need for physical sectioning.
- Lingbo Jin
- , Yubo Tang
- & Ashok Veeraraghavan
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Context-aware deep learning enables high-efficacy localization of high concentration microbubbles for super-resolution ultrasound localization microscopy
Ultrasound localisation microscopy enables deep tissue microvascular imaging. Here, authors introduce LOCA-ULM, a deep learning pipeline enhancing localisation accuracy in high microbubble concentrations. LOCA-ULM reveals dense cerebrovascular networks and enhances the sensitivity of functional ULM.
- YiRang Shin
- , Matthew R. Lowerison
- & Pengfei Song
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Article
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Flexible large-area ultrasound arrays for medical applications made using embossed polymer structures
Current ultrasound transducers are bulky and rigid. Here, the authors describe a new way to realize large-area and mechanically flexible ultrasound arrays on polymer foils suited for wearable ultrasound applications
- Paul L. M. J. van Neer
- , Laurens C. J. M. Peters
- & Gerwin H. Gelinck
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Article
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Microinterfaces in biopolymer-based bicontinuous hydrogels guide rapid 3D cell migration
Extracellular microinterfaces provide cells with migration tracks in vivo. Here, the authors introduce these microtracks into bicontinuous hydrogels to elicit rapid cell migration in 3-dimensional contexts.
- Karen L. Xu
- , Nikolas Di Caprio
- & Jason A. Burdick
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Article
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One-photon three-dimensional printed fused silica glass with sub-micron features
3D-printed glass holds great potential. However, it is challenging to control both the dimension and the resolution of the printed material. Here, authors present a one-photon 3D printing approach to produce high-performance fused silica glass with sub-micron resolution and millimetric dimensions.
- Ziyong Li
- , Yanwen Jia
- & Xiewen Wen
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Article
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Single drop cytometry onboard the International Space Station
Real-time lab analysis is key to support clinical research during space missions. Here, the authors show scant test samples can be measured in microgravity using a miniature cytometery-based analyzer, the rHEALTH ONE with specific spaceflight modifications.
- Daniel J. Rea
- , Rachael S. Miller
- & Eugene Y. Chan
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Article
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High-security learning-based optical encryption assisted by disordered metasurface
In this work, the employment of disordered metasurface as an ultra-stable and actively polarized speckle generator in a passive manner, coupled with a double-secure treatment to the plaintext, enables a highly secure speckle-based cryptosystem.
- Zhipeng Yu
- , Huanhao Li
- & Puxiang Lai
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Article
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Versatile human cardiac tissues engineered with perfusable heart extracellular microenvironment for biomedical applications
The application of engineered cardiac tissues is limited due to their immaturity and lack of functionality. Here, the authors develop an integrated culture platform featuring heart extracellular matrix cultured in a microfluidic chip to facilitate cardiac tissue development for versatile biomedical applications.
- Sungjin Min
- , Suran Kim
- & Seung-Woo Cho
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Ultrasound-induced reorientation for multi-angle optical coherence tomography
Accessing multi-angle views of organoids is important for biology and oncology. The authors propose ultrasound-induced reorientation for multi-angle optical coherence tomography, using a 3D-printed acoustic trap to levitate and rotate samples with a model-based algorithm for reconstruction.
- Mia Kvåle Løvmo
- , Shiyu Deng
- & Monika Ritsch-Marte
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Subwavelength dielectric waveguide for efficient travelling-wave magnetic resonance imaging
Achieving uniform spin excitation, crucial for MRI, is challenging in the electrically large human body at UHF. Here, authors introduce an innovative dielectric waveguide specifically designed for traveling-wave MRI, which enhances homogeneity and efficiency through effective wave manipulation.
- Yang Gao
- , Tong Liu
- & Xiaotong Zhang
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Article
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Speaking without vocal folds using a machine-learning-assisted wearable sensing-actuation system
Addressing challenges in voice disorders, the authors present a self-powered, wearable sensor-actuator system based on magnetoelasticity. This innovation enables assisted speaking by capturing laryngeal movements and translating them into voice signals, bypassing the vocal folds.
- Ziyuan Che
- , Xiao Wan
- & Jun Chen
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Article
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Spatially selective delivery of living magnetic microrobots through torque-focusing
The delivery of therapeutic payloads and living vectors to tumors remains a clinical challenge. Here the authors explore a spatially targeted control strategy applying torque density to magnetotactic bacteria, demonstrating feasibility in vitro and in vivo.
- Nima Mirkhani
- , Michael G. Christiansen
- & Simone Schuerle
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Article
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Fully bioresorbable hybrid opto-electronic neural implant system for simultaneous electrophysiological recording and optogenetic stimulation
Bioresorbable neural implants offer a promising solution to the challenges of secondary surgeries required for the removal of implanted devices. Here, the authors introduce a fully bioresorbable flexible hybrid opto-electronic system for simultaneous electrophysiological recording and optogenetic stimulation.
- Myeongki Cho
- , Jeong-Kyu Han
- & Ki Jun Yu
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Article
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Janus microparticles-based targeted and spatially-controlled piezoelectric neural stimulation via low-intensity focused ultrasound
Wireless and localized stimulation of neural cells remains challenging. Here, the authors propose piezoelectric magnetic Janus microparticles that can target and stimulate neurons under low-intensity ultrasound through voltage-gated ion channels.
- Mertcan Han
- , Erdost Yildiz
- & Metin Sitti
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Article
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Long-term monitoring of ultratrace nucleic acids using tetrahedral nanostructure-based NgAgo on wearable microneedles
Monitoring of biomarkers with wearable devices holds potential for personal health management. Here the authors demonstrate a wearable device based on tetrahedral DNA nanostructures and prokaryotic argonaute to monitor real-time sepsis-associated nucleic acid
- Bin Yang
- , Haonan Wang
- & Xueen Fang
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Magnetically driven capsules with multimodal response and multifunctionality for biomedical applications
Untethered capsules exhibit clinical promise for diagnosing and treating gastrointestinal diseases. Here, the authors develop small-scale magnetically driven capsules featuring a distinct magnetic soft valve, integrating multiple functional and motion modalities for biomedical applications.
- Yuxuan Sun
- , Wang Zhang
- & Liang Li
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Article
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High-throughput barcoding of nanoparticles identifies cationic, degradable lipid-like materials for mRNA delivery to the lungs in female preclinical models
Identifying pulmonary delivery of lipid libraries poses an obstacle for mRNA drugs. Here, the authors use a barcoded screening system to identify lung-targeting of cationic, degradable lipid-like materials for mRNA delivery and gene editing in female preclinical models.
- Lulu Xue
- , Alex G. Hamilton
- & Michael J. Mitchell
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Perspective
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Cellular reprogramming as a tool to model human aging in a dish
The development of human cellular models of aging that surpass the limitations of animal models of aging is urgent. Here, the authors explore the opportunities and limitations of cellular reprogramming to create reliable aging in vitro models and their potential for the discovery of anti-aging compounds.
- Patricia R. Pitrez
- , Luis M. Monteiro
- & Lino Ferreira
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Article
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Automatic data-driven design and 3D printing of custom ocular prostheses
Manual processes to produce ocular prostheses are time-consuming and yield varying quality. Here, authors present an automatic digital end-to-end process for custom ocular prostheses. It creates shape and appearance from image data of an OCT device and produces them using a full-colour 3D printer.
- Johann Reinhard
- , Philipp Urban
- & Mandeep S. Sagoo
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Article
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In-vivo integration of soft neural probes through high-resolution printing of liquid electronics on the cranium
Neural systems are often bulky and heavy. Here, the authors produce a conformable neural interface for mice using liquid metals directly printed on the skull that can monitor neural activities with long-term stability.
- Young-Geun Park
- , Yong Won Kwon
- & Jang-Ung Park
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Article
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Multi-night cortico-basal recordings reveal mechanisms of NREM slow-wave suppression and spontaneous awakenings in Parkinson’s disease
Using at-home intracranial DBS recordings in PD participants, the authors found subcortical beta has an inverse effect on cortical slow-wave in NREM sleep, rises before awakenings and found >88% accuracy in NREM vs Wake classification in brief 5 s epochs.
- Md Fahim Anjum
- , Clay Smyth
- & Simon Little
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Perspective
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Shaping high-performance wearable robots for human motor and sensory reconstruction and enhancement
Wearable devices and exoskeletons can restore and augment the user’s capability but are not necessarily perceived them as part of their bodies. In this perspective, the authors reflect on the importance of integrating environmental, physiological, and physical information to improve the embodiment of wearable robots.
- Haisheng Xia
- , Yuchong Zhang
- & Zhijun Li
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Article
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A wireless battery-free eye modulation patch for high myopia therapy
The proper axial length of the eye is crucial for achieving emmetropia. Here, authors introduce a wireless battery-free eye modulation patch designed to correct high myopia and prevent relapse.
- Tianyan Zhong
- , Hangjin Yi
- & Xinyu Xue
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Article
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In situ combinatorial synthesis of degradable branched lipidoids for systemic delivery of mRNA therapeutics and gene editors
Branched ionizable lipids have aroused great interest for mRNA delivery. Here, the authors devise an in situ construction method for combinatorial synthesis of degradable branched ionizable lipids and summarize key design criteria to enable potent delivery of mRNA therapeutics and gene editors.
- Xuexiang Han
- , Junchao Xu
- & Michael J. Mitchell
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Article
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Virtual histological staining of unlabeled autopsy tissue
Conventional staining of post-mortem samples can be affected by several factors, including tissue autolysis. Here, the authors demonstrate a virtual staining tool using a trained neural network to turn autofluorescence images of label-free autopsy tissue into brightfield equivalent images.
- Yuzhu Li
- , Nir Pillar
- & Aydogan Ozcan
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Article
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Large language models streamline automated machine learning for clinical studies
A knowledge gap persists between machine learning developers and clinicians. Here, the authors show that the Advanced Data Analysis extension of ChatGPT could bridge this gap and simplify complex data analyses, making them more accessible to clinicians.
- Soroosh Tayebi Arasteh
- , Tianyu Han
- & Sven Nebelung
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Article
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Biomimetic computer-to-brain communication enhancing naturalistic touch sensations via peripheral nerve stimulation
Loss of communication between the brain and the body severely impacts the sensorimotor abilities of disabled individuals. Here, the authors design and test a neuroscience-driven framework for advancing bionic devices that leverages biomimetic stimulation to induce physiologically plausible information flow in animals and enhances patient performance with neuroprostheses.
- Giacomo Valle
- , Natalija Katic Secerovic
- & Stanisa Raspopovic
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Article
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Molecular co-assembled strategy tuning protein conformation for cartilage regeneration
The assembly of oligopeptide and polypeptide molecules can reconstruct various ordered advanced structures. Here the authors develop a “molecular velcro”-inspired amphiphilic supramolecular co-assembly strategy, which improves the mechanical strength and cartilaginous regeneration efficiency through conformation transition.
- Chengkun Zhao
- , Xing Li
- & Yong Sun
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Article
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A microfluidic platform integrating functional vascularized organoids-on-chip
Vascularization remains a significant challenge in organoid technology. Here, the authors develop a microfluidic platform that enhances organoid growth, function and maturation, by establishing functional perfusable vascular networks.
- Clément Quintard
- , Emily Tubbs
- & Xavier Gidrol
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Article
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Vascular network-inspired fluidic system (VasFluidics) with spatially functionalizable membranous walls
Functional features in the spatiotemporal regulation of blood chemistry are not much explored. Here authors show vascular network-inspired fluidics, functionalizable for different region-specific trans-wall transport to regulate fluids over space and time.
- Yafeng Yu
- , Yi Pan
- & Ho Cheung Shum
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Modeling early pathophysiological phenotypes of diabetic retinopathy in a human inner blood-retinal barrier-on-a-chip
Here the authors develop perfusable inner blood-retinal barrier-specific microvascular networks with human primary retinal microvascular cells. They show that chronic diabetic stimulation leads to the generation of early hallmarks of diabetic retinopathy, including pericyte and capillary dropout, ghost vessels, and inflammation.
- Thomas L. Maurissen
- , Alena J. Spielmann
- & Héloïse Ragelle
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A 3D printable tissue adhesive
Tissue adhesives have received significant interest for their clinical utility but are typically incompatible with advanced manufacturing methods. Here, the authors introduce a 3D printable tissue adhesive for the fabrication of patches and devices for diverse biomedical applications.
- Sarah J. Wu
- , Jingjing Wu
- & Xuanhe Zhao
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Article
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Shape-recovery of implanted shape-memory devices remotely triggered via image-guided ultrasound heating
Focused ultrasound could be used to change the geometry of implanted shape-memory medical devices noninvasively. Here, the authors demonstrate this concept on large animal models, showing device removal and trigger drug release.
- Yang Zhu
- , Kaicheng Deng
- & William R. Wagner
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Article
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Mechanically resilient hybrid aerogels containing fibers of dual-scale sizes and knotty networks for tissue regeneration
Aerogels are suitable for soft tissue engineering, but often come with brittleness. Here the authors develop a hybrid aerogel with micro- and nanofiber networks that optimizes tensile moduli and fracture energies and show that these materials are super-elastic, fostering rapid tissue ingrowth and allowing minimally invasive procedures.
- S. M. Shatil Shahriar
- , Alec D. McCarthy
- & Jingwei Xie
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Article
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An actor-model framework for visual sensory encoding
Encoding and downsampling images is key for visual prostheses. Here, the authors show that an actor-model framework using the inherent computation of the retinal network yields better performance in downsampling images compared to learning-free methods.
- Franklin Leong
- , Babak Rahmani
- & Diego Ghezzi
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Article
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Bioinspired handheld time-share driven robot with expandable DoFs
Handheld robots are limited in controllable degrees of freedom, which can result in lower dexterity for clinical applications. Here, Wang et al. report a handheld time-share driven robot with one motor that powers multiple motion modules for high-dextrous operation.
- Yunjiang Wang
- , Xinben Hu
- & Haoran Jin
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Article
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A drug-free cardiovascular stent functionalized with tailored collagen supports in-situ healing of vascular tissues
The efficacy of drug-eluting stents remains limited due to delayed reendothelialization, impaired intimal remodeling, and potentially increased late restenosis. Here the authors propose a one-produces-multi stent coating, a drug-free strategy that supports in situ healing of vascular tissues, as demonstrated in rabbit and porcine models.
- Haoshuang Wu
- , Li Yang
- & Yunbing Wang
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Article
| Open Access
LNP-RNA-engineered adipose stem cells for accelerated diabetic wound healing
Adipose stem cells are promising therapeutic agents in tissue regeneration. Here the authors develop a lipid nanoparticle/RNA engineering platform to enhance the protein production of these cells, which demonstrate superior healing efficacy in a mouse model of diabetic cutaneous wounds.
- Yonger Xue
- , Yuebao Zhang
- & Yizhou Dong
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Article
| Open Access
Shape-changing electrode array for minimally invasive large-scale intracranial brain activity mapping
The invasiveness of extensive craniotomy hinders large-scale cortex mapping. Here, the authors developed a flexible, shape-changing electrode array which enables minimally invasive implantation and achieves high spatiotemporal resolution brain mapping.
- Shiyuan Wei
- , Anqi Jiang
- & Xiaojie Duan
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Article
| Open Access
Machine learning-based high-frequency neuronal spike reconstruction from low-frequency and low-sampling-rate recordings
Multichannel neural recording enhances understanding of brain function, but handling large data is challenging. Here, the authors develop machine learning-based high frequency spike reconstruction from subsampled low-frequency neuronal signals.
- Nari Hong
- , Boil Kim
- & Hongki Kang
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Article
| Open Access
Engineering tumor-colonizing E. coli Nissle 1917 for detection and treatment of colorectal neoplasia
There is an unmet medical need for the detection and treatment of early adenomas to prevent their progression to malignant disease. Here the authors show that orally administered E. coli Nissle 1917 can selectively colonize adenomas in mouse models and in patients as a detection tool, as well as deliver immunotherapeutics for colorectal neoplasia treatment.
- Candice R. Gurbatri
- , Georgette A. Radford
- & Tal Danino
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Article
| Open Access
A magnetic multi-layer soft robot for on-demand targeted adhesion
Magnetic soft robots offer a non-invasive way to deliver bioadhesives to targeted lesion sites to accelerate the healing. Authors present a magnetic multi-layer soft robot that is capable of performing navigated locomotion on biological tissues and on-demand multi-target adhesion at different sites.
- Ziheng Chen
- , Yibin Wang
- & Jiangfan Yu
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Article
| Open Access
Dual electrical stimulation at spinal-muscular interface reconstructs spinal sensorimotor circuits after spinal cord injury
Electrical signals with characteristic parameters for reconstructing neural circuits remain incompletely understood, limiting the therapeutic potential of electrical neuromodulation techniques. Here, the authors demonstrate that dual electrical stimulation at 10–20 Hz rebuilds the spinal sensorimotor neural circuit after spinal cord injury, indicating the characteristic signals of circuit remodeling.
- Kai Zhou
- , Wei Wei
- & Yaobo Liu
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Article
| Open Access
Flexible, scalable, high channel count stereo-electrode for recording in the human brain
Electrodes available for deep brain recording and stimulation have a number of limitations. Here the authors describe a thin-film depth electrode that may offer improved spatial and temporal resolution for recording brain activity.
- Keundong Lee
- , Angelique C. Paulk
- & Shadi. A. Dayeh
Untethered soft actuators for soft standalone robotics