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Biomaterials are those materials — be it natural or synthetic, alive or lifeless, and usually made of multiple components — that interact with biological systems. Biomaterials are often used in medical applications to augment or replace a natural function.
Three-dimensional (3D) priming, which encapsulates human adipose derived stem cells into hydrogel systems, greatly reduces the amount of time required to induce an efficient retroviral transduction compared with the conventional two-dimensional (2D) method. This facilitating effect is closely related to the acceleration of cell cycle regulation (G1 arrest and G1/S transition) by 3D priming.
We produced a human recombinant Hsp70-1A fused with the cell-penetrating peptide Tat (Tat-Hsp70-1A), that was neuroprotective in vitro against the dopaminergic toxin 6-hydroxydopamine (6-OHDA). We developed and characterized a Tat-Hsp70-1A delivery system by exploiting an injectable, biocompatible, biodegradable semi-interpenetrating polymer network composed of collagen (COLL) and low-molecular-weight hyaluronic acid (LMW HA), structured with gelatin particles. Tat-Hsp70-1A diffused from the selected COLL-LMW HA composites in an active form and protected dopaminergic cells and neurons in Parkinson’s disease (PD) models. Furthermore, Tat-Hsp70-loaded composites conveyed neuroprotection both at behavioral and dopaminergic neuronal level against striatal injection of 6-OHDA.
Kota Miura et al. develop the THermal-Elution-based TAg (THETA) system that allows one-step isolation of tagged proteins. The temperature-dependent protein-peptide interaction used in the THETA system ensures high specificity for protein purification.
There is interest in developing long-lasting local anaesthetics for a range of applications. Here, the authors report on the application of tetrodotoxin conjugated to amphiphilic biodegradable polymer to reduce systemic toxicity, achieve sustained release and investigate application as a local anaesthetic.
The aggregation states at the surface of spin-coated scaffold films composed of a multifunctional hyperbranched polymer (HBP) were characterized. While perfluorohexylethyl groups were segregated at the surface in air, the surface in water turned to be hydrophilic to minimize the free energy at the outermost region in the film. This surface reorganization was discernably faster and more remarkable for the non-annealed HBP film than for the annealed one. Fibronectin, which promoted the cellular behaviors, was more adsorbed onto the non-annealed HBP film.
The first clinical success of immunotherapeutics for cancer treatment and the appreciation that tissue regeneration can be greatly improved by precisely and locally modulating the immune response are evidence that immunotherapy is poised to revolutionize the way we treat disease.
In biological systems, order typically emerges from out-of-equilibrium molecular processes that control both static patterns and dynamic changes. Now, the self-regulating assembly and disassembly of a synthetic system has been achieved on the micrometre scale, by coupling the growth of a DNA nanotube to a biochemical oscillator.
Over-expression of a transcriptional factor, Alx3, has been shown to revitalize the regenerative capacity of adult progenitor cells to promote enhanced stromal vascularization and formation of parenchymal dental pulp tissue in vivo.