Biomaterials

Biomaterials are those materials — be it natural or synthetic, alive or lifeless, and usually made of multiple components — that interact with biological systems. Biomaterials are often used in medical applications to augment or replace a natural function.

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Latest Research and Reviews

  • Research |

    Wnt3a protein has been immobilized on a biocompatible bandage and is now shown to induce oriented asymmetric cell division of human skeletal stem cells and can also promote bone tissue repair in vivo.

    • Yoshihisa Okuchi
    • , Joshua Reeves
    • , Soon Seng Ng
    • , Daniel H. Doro
    • , Sergi Junyent
    • , Karen J. Liu
    • , Alicia J. El Haj
    •  & Shukry J. Habib
  • Research |

    Poly(γ-glutamic acid) (PGA) is a biopolymer produced by Bacillus spp. via the γ-amide linkages of d- and/or l-glutamate. PgsB, PgsC, and PgsA are the minimum protein set required for PGA production in B. subtilis, and PgsE improves PGA productivity. Analysis by size-exclusion chromatography combined with multiangle laser light scattering revealed that the molecular weight of PGA was Mw = 2,900,000 g mol−1 or predominantly Mw = 47,000 g mol−1 in preparations derived from B. subtilis cells with or without pgsE, respectively. PgsE may be required to increase the apparent molecular weight of PGA.

    • Ken-Ichi Fujita
    • , Takashi Tomiyama
    • , Takahiro Inoi
    • , Takashi Nishiyama
    • , Eriko Sato
    • , Hideo Horibe
    • , Ryosuke Takahashi
    • , Shinichi Kitamura
    • , Yoshihiro Yamaguchi
    • , Akira Ogita
    •  & Toshio Tanaka
  • Research
    | Open Access

    Jia, Wu, Kim et al. show that cyanidin-3-O-glucoside (C3G), a major dietary anthocyanin, functions as a ligand for PPARalpha to regulate energy metabolism and insulin sensitivity in mouse models of obesity and diabetes. This study suggests that C3G slows down the metabolism of glucose, making it a promising therapeutic agent.

    • Yaoyao Jia
    • , Chunyan Wu
    • , Young-Suk Kim
    • , Seung Ok Yang
    • , Yeonji Kim
    • , Ji-Sun Kim
    • , Mi-Young Jeong
    • , Ji Hae Lee
    • , Bobae Kim
    • , Soyoung Lee
    • , Hyun-Seok Oh
    • , Jia Kim
    • , Min-Young So
    • , Ye Eun Yoon
    • , Trung Thanh Thach
    • , Tai Hyun Park
    •  & Sung-Joon Lee
  • Research
    | Open Access

    Cellulose is synthesized as microfibrils of β-1,4-linked glucan chains arranged in a crystalline lattice. Here Ye et al. use grazing incidence wide angle X-ray scattering to show that cellulose crystals are preferentially orientated parallel to the plant cell wall, rather than as twisting microfibrils as previously hypothesized.

    • Dan Ye
    • , Sintu Rongpipi
    • , Sarah N. Kiemle
    • , William J. Barnes
    • , Arielle M. Chaves
    • , Chenhui Zhu
    • , Victoria A. Norman
    • , Alexander Liebman-Peláez
    • , Alexander Hexemer
    • , Michael F. Toney
    • , Alison W. Roberts
    • , Charles T. Anderson
    • , Daniel J. Cosgrove
    • , Esther W. Gomez
    •  & Enrique D. Gomez

News and Comment

  • News and Views |

    Functional single-cell liver hemi-canaliculi have been generated in a synthetic microenvironment using a reductionist approach. It is shown that the interaction between the extracellular matrix and static cadherin is sufficient to develop an apicobasal polarity independently of the contact with neighbouring cells.

    • Covadonga Díaz-Díaz
    •  & Fernando Martín-Belmonte
    Nature Materials 19, 935-937
  • News and Views |

    The cell-selective permeability of a retrievable microporous device encapsulating human therapeutic cells and implanted in the intraperitoneal space of mice provides long-term protection to the transplanted cells by dampening foreign-body responses and preventing the immune rejection of the graft.

    • Ken Coppieters
    • , Louise Winkel
    •  & Matthias von Herrath
  • Comments and Opinion |

    Nano-formulating dexamethasone, and administering it via intravenous injection or inhalation, may help to improve anti-COVID-19 treatment efficacy by targeting the potent corticosteroid drug to hyper-activated immune cells, by potentiating its anti-oedema activity and by exploiting its anti-fibrotic effects.

    • Twan Lammers
    • , Alexandros Marios Sofias
    • , Roy van der Meel
    • , Raymond Schiffelers
    • , Gert Storm
    • , Frank Tacke
    • , Steffen Koschmieder
    • , Tim H. Brümmendorf
    • , Fabian Kiessling
    •  & Josbert M. Metselaar
    Nature Nanotechnology 15, 622-624