Biomaterials

  • Article
    | Open Access

    Isopropenyl ethers (IPPEs) are essential intermediates for obtaining ketal-based prodrugs and biomaterials, but traditional approaches for their synthesis are limited by poor functional group compatibility and harsh reaction conditions. Here, the authors report an organocatalytic transisopropenylation approach for IPPE synthesis in mild reaction conditions and with wide range of substrates, and use it to prepare acid-sensitive ketal-linked prodrugs and biomaterials.

    • Na Yu
    • , Yang Xu
    •  & Shutao Guo
  • Article
    | Open Access

    Implant infection is the most common mode of joint replacement failure with serious complications. Here, the authors report on the in vivo application of a prophylactic coating technology that can incorporate a range of antibiotics and be applied in the operating room prior to implantation.

    • Weixian Xi
    • , Vishal Hegde
    •  & Tatiana Segura
  • Article
    | Open Access

    Circularised nanodiscs (cNDs) are able to stabilise large lipid bilayer patches and are used for structural and functional studies. Current techniques to build cNDs have numerous steps and low yields; here the authors report a single step construction method using the SpyCatcher-SpyTag system.

    • Shanwen Zhang
    • , Qian Ren
    •  & Huan Bao
  • Article
    | Open Access

    Bioinspired materials require an understanding of how biomaterials achieve the materials properties. Here, the authors report on the load-bearing shell of Discinisca tenuis and explore how hydration changes the dry shell from hard and stiff to soft and flexible within minutes by reorganisation caused by organic matrix swelling.

    • Johannes Ihli
    • , Anna S. Schenk
    •  & Fabio Nudelman
  • Article
    | Open Access

    Implantation-caused foreign-body response is a commonly encountered issue and can result in failure of implants. Here, the authors demonstrate that a highly water soluble, biocompatible, and easily accessible poly-DL-serine hydrogel can mitigate foreign-body response.

    • Donghui Zhang
    • , Qi Chen
    •  & Runhui Liu
  • Article
    | Open Access

    Moisture-induced energy generation is a potential green energy power source. Here, the authors report a moisture-induced autonomous surface potential oscillation phenomenon and apply it to the demonstration of energy harvesters with long persistence time and good energy density

    • Yu Long
    • , Peisheng He
    •  & Liwei Lin
  • Article
    | Open Access

    The control of reactive oxygen species in cancer cells is an attractive approach for anticancer applications. Here, the authors create a peroxisome inspired lactate oxidase and catalase loaded hydrogel with iron nanoparticles and NIR photosensitizer for glutathione activated chemodynamic and photodynamic therapy.

    • Xing Qin
    • , Chu Wu
    •  & Yongsheng Li
  • Article
    | Open Access

    Here, the authors engineer microbial production of muscle titin fibers with highly desirable mechanical properties and provide structural analyses that explain the molecular mechanisms underlying high performance of this polymer with potential uses in biomedicine and textile industries, among others.

    • Christopher H. Bowen
    • , Cameron J. Sargent
    •  & Fuzhong Zhang
  • Article
    | Open Access

    A variety of artificial cells springs from the functionalization of liposomes with proteins but these models suffer from low durability without repair and replenishment mechanisms. Here, the authors show that synthetic amphiphile membranes undergo SNARE-mediated fusion, and determine bending rigidity and pore edge tension as key parameters for fusion.

    • Lado Otrin
    • , Agata Witkowska
    •  & Tanja Vidaković-Koch
  • Article
    | Open Access

    Understanding nanomaterials interactions with complement is important for a number of applications. Here, the authors study the interaction of sub 6 nm dendrimers with complement and show the small dendrimers escape complement activation but do interact with IgM to trigger lectin-pathway complement activation.

    • Lin-Ping Wu
    • , Mario Ficker
    •  & Seyed M. Moghimi
  • Article
    | Open Access

    Lipid membrane disruption is often associated with disease but is also essential to a range of biosensing and therapeutic techniques. Here, the authors report on the development of DNA-based particles that, upon exposure to an external cue, can aggregate, disrupt lipid membranes, and arrest the motion of bacteria.

    • Michal Walczak
    • , Ryan A. Brady
    •  & Lorenzo Di Michele
  • Article
    | Open Access

    Developing effective treatments for noncompressible hemorrhages remains a challenge. Here the authors engineer alkylated chitosan sponges with highly interconnective microchannels and demonstrate anti-infective activity, as well as higher pro-coagulant, hemostatic and wound healing capacities compared to clinically-used materials in rat and pig liver models.

    • Xinchen Du
    • , Le Wu
    •  & Meifeng Zhu
  • Article
    | Open Access

    Brain organoids derived from human pluripotent stem cells can model human brain development and disease, though current culture systems fail to ensure reliable production of high-quality organoids. Here the authors combine human brain extracellular matrix and culture in a microfluidic device to promote structural and functional maturation of human brain organoids.

    • Ann-Na Cho
    • , Yoonhee Jin
    •  & Seung-Woo Cho
  • Article
    | Open Access

    Silica formation in diatoms is of interest for a range of different subjects from biomimetics to oceanography. Here the authors study the formation of silicified extensions in diatoms and find that unlike cell wall elements, that form in the cytoplasm, the extensions have a different formation mechanism outside the cytoplasm.

    • Boaz Mayzel
    • , Lior Aram
    •  & Assaf Gal
  • Article
    | Open Access

    Despite many reports on nanoparticle-covalent organic frameworks (COF) composites, a universal strategy for the synthesis of monodisperse core-shell structured COF nanocomposites remains challenging. Here, the authors develop a strategy for interfacial growth of highly crystalline COFs on functional nanoparticles with abundant optical, electrical and magnetic properties.

    • Liang Chen
    • , Wenxing Wang
    •  & Xiaomin Li
  • Article
    | Open Access

    Fine tuning of mechanical properties in elastomers is important for application of elastomers in flexible devices and biomedical field. Here, the authors prepare a nacre inspired PDMS-montmorrillonite composite with good mechanical properties and demonstrate crack tracing using aggregation-induced emission luminogens.

    • Jingsong Peng
    • , Antoni P. Tomsia
    •  & Qunfeng Cheng
  • Article
    | Open Access

    The unique properties of self-healing materials hold great potential in the field of biomedical engineering. Here, the authors designed a series of biodegradable and biocompatible self-healing elastomers with tunable mechanical properties, and apply them to various disease models in vivo, including aortic aneurism, bone fracture and nerve amputation.

    • Chenyu Jiang
    • , Luzhi Zhang
    •  & Xiaofeng Ye
  • Article
    | Open Access

    The development of tissue-like materials which replicate the mechanical properties of tissue is of interest for a range of applications. Here, the authors report on the development of radial asters that form a gel network to stiffen in compression and soften in extension, resembling tissue mechanics.

    • Qingqiao Xie
    • , Yuandi Zhuang
    •  & Lingxiang Jiang
  • Article
    | Open Access

    Phospholipase A2 (PLA2) inhibitors have been shown to be able to treat acute pancreatitis, but are toxic with systemic application. Here the authors design a nanoparticle with macrophage membrane components to carry PLA2 inhibitor to macrophages and treat pancreatitis in mice, with no evidence of toxicity.

    • Qiangzhe Zhang
    • , Julia Zhou
    •  & Liangfang Zhang
  • Article
    | Open Access

    Shape memory scaffolds are needed for minimally invasive tissue repair and void filling. Here the authors report on the development of 4D printed polycarbonate-based scaffolds with surface degradation properties which fill voids without deforming tissue and allow for tissue ingrowth with reduced immune response.

    • Andrew C. Weems
    • , Maria C. Arno
    •  & Andrew P. Dove
  • Article
    | Open Access

    Minimally invasive materials that match tissues mechanical properties are needed for biomedical applications. Here, the authors report on brush-like polymers which can be injected and cured in situ, resulting in elastomeric implants which mechanically blend with surrounding tissue and show minimal foreign body response.

    • Erfan Dashtimoghadam
    • , Farahnaz Fahimipour
    •  & Sergei S. Sheiko
  • Article
    | Open Access

    The therapeutic application of small interfering RNA (siRNA) is challenging due to its non-specific targeting and delivery issues. Here, the authors report an endogenous micro-RNA guided and hybridisation chain reaction-promoted siRNA delivery system encapsulated in tumour-derived extracellular vesicles, with cancer-specific activation, and achieve silencing of hypoxia-related genes.

    • Xue Gong
    • , Haizhou Wang
    •  & Fuan Wang
  • Review Article
    | Open Access

    Antimicrobial resistance is a growing global problem and low dimensional materials have emerged as a potential solution. Here, the authors review the progress which has been made on low dimensional antimicrobials looking at the materials synthesis, modes of action and currently applications.

    • Z. L. Shaw
    • , Sruthi Kuriakose
    •  & Sumeet Walia
  • Article
    | Open Access

    Optimizing the concentration of different functional peptides on a surface can be a complex process. Here, the authors report on the use of a click immobilization strategy to create gradients of two different functional peptides on a surface to screen different density functions for rapid optimization.

    • Zhou Fang
    • , Junjian Chen
    •  & Chuanbin Mao
  • Article
    | Open Access

    Postsurgical adhesions are a problem during routine cardiothoracic procedures. Here, the authors report on a catechol functionalised hydrogel as an anti-adhesion material with improved retention on the heart which is biocompatible and biodegradable with minimal swelling, demonstrating application in vivo.

    • Masaki Fujita
    • , Gina M. Policastro
    •  & Karen L. Christman
  • Article
    | Open Access

    Printed biosensors are important for health monitoring and research purposes. Here, the authors report on the development of a soft poroelastic silicone based sensor which can be easily printed and is resistant to mechanical strain hysteresis, allowing for more accurate electrophysiology readings and imaging.

    • Bongjoong Kim
    • , Arvin H. Soepriatna
    •  & Chi Hwan Lee
  • Article
    | Open Access

    Organising proteins in 2D and 3D is needed to develop complex bimolecular materials for a range of applications. Here, the authors report the encapsulation of ferritin and apoferritin in DNA-based voxels with programmed assembly to generate both 2D and 3D protein lattices and demonstrate the retention of protein function.

    • Shih-Ting Wang
    • , Brian Minevich
    •  & Oleg Gang
  • Article
    | Open Access

    Studying the development of silk structure is important for understanding material properties and biomimetics. Here, the authors use ex vivo processing to characterise the stages of silk spinning and identify a consolidation phase where transient water pockets emerge due to multiple factors leading to nanofibril coalescence.

    • Quan Wan
    • , Mei Yang
    •  & Mingying Yang
  • Article
    | Open Access

    Biomedical glues often face a challenge in providing strong adhesion and providing remodelling capabilities. Here the authors report on the development of a biocompatible and biodegradable protein-based coacervate adhesive and demonstrate application in haemostasis and wound healing using pig models.

    • Chao Ma
    • , Jing Sun
    •  & Andreas Herrmann
  • Article
    | Open Access

    A major goal in Engineering Biology and Materials Science is the development of active, autonomous scaffolds that mimic those present in biological cells. Here the authors report a toolkit for programming the dynamic behaviour of nucleic acid scaffolds in minimal cell-like compartments.

    • Siddharth Agarwal
    • , Melissa A. Klocke
    •  & Elisa Franco
  • Article
    | Open Access

    3D culture systems can provide critical insights into cellular behaviour. Here, the authors study the binding timescale of dynamic crosslinks and the conjugation stability of cell-adhesive ligands in cell–hydrogel network interactions to evaluate the impact on stem cell behaviour, mechanosensing and differentiation.

    • Boguang Yang
    • , Kongchang Wei
    •  & Liming Bian
  • Article
    | Open Access

    Cell based materials production has potential for generating diverse materials with a range of functions. Here, the authors report development of living fabrication of biohybrid semi interpenetrating polymer networks by encapsulating protein producing bacteria within polymer microcapsules.

    • Zhuojun Dai
    • , Xiaoyu Yang
    •  & Lingchong You
  • Article
    | Open Access

    Current tissue engineering strategies lack materials that promote angiogenesis. Here the authors develop a microfluidic in vitro model in which chemokine-guided endothelial cell sprouting into a tunable hydrogel is followed by the formation of perfusable lumens to determine the material properties that regulate angiogenesis.

    • Jifeng Liu
    • , Hongyan Long
    •  & Britta Trappmann
  • Article
    | Open Access

    Current methods for the modular assembly of biomaterials are associated with limitations. Here the authors implement vapor-phase deposition to fabricate 3D polymeric materials that permit biomolecule functionalization, tunable mass transport and mechanical properties, as well as control over boundaries between compartments, and analyze the behavior of 3D encapsulated cells.

    • Chih-Yu Wu
    • , Ting-Ying Wu
    •  & Hsien-Yeh Chen
  • Article
    | Open Access

    For bio-inspired neuromorphic interfaces to emulate biological signal processing and self-sustainability, the mismatch between sensing and computing signals must be addressed. Here, the authors report sensor-driven, integrated neuromorphic systems with signal matching at the biological level.

    • Tianda Fu
    • , Xiaomeng Liu
    •  & Jun Yao
  • Article
    | Open Access

    Macrophages perform diverse functions during immune responses, but the molecular mechanisms by which physical properties of the tissue regulate macrophage behavior remain unknown. Here the authors find that Piezo1 is a mechanosensor of stiffness, and that its activity modulates macrophage polarization responses.

    • Hamza Atcha
    • , Amit Jairaman
    •  & Wendy F. Liu
  • Review Article
    | Open Access

    Water scarcity is a rapidly spreading global challenge but water purification technologies are often not sustainable. Here, the authors review the research on water purification technologies based on protein nanofibrils as a green and affordable solution to alleviate a water crisis.

    • Mohammad Peydayesh
    •  & Raffaele Mezzenga
  • Review Article
    | Open Access

    Given the early failing of therapeutic nanomedicine in the clinic the importance of understanding bio-nano interactions and biosystem parameters has gained much attention. Here, the authors review the work to date that looks at the impact of sex on the applications and outcomes of nanomedicine.

    • Mohammah Javad Hajipour
    • , Haniyeh Aghaverdi
    •  & Morteza Mahmoudi
  • Article
    | Open Access

    While rheology studies have contributed to the understanding of the viscoelastic properties of living cells, the use of higher frequencies promises elucidate the link between cellular and molecular properties. Here authors introduce a rheological assay that measures the cell mechanical response across a continuous frequency range ≈ 1 – 40 kHz.

    • Gotthold Fläschner
    • , Cosmin I. Roman
    •  & Daniel J. Müller
  • Article
    | Open Access

    Molecular transport across physical barriers requires pores that connect to the environment. Here, the authors report on a solution based dynamic study into the effects of size and charge on the transport through the pores of virus-like particles derived from bacteriophage P22 using an encapsulated redox system.

    • Ekaterina Selivanovitch
    • , Benjamin LaFrance
    •  & Trevor Douglas
  • Article
    | Open Access

    Small interfering RNA (siRNA) is used to regulate gene expression for therapeutic purposes, but the design of stable and efficient siRNA delivery systems is challenging. Here, the authors develop a siRNA-encapsulated and aptamer-incorporated core/shell nanoparticle for controlled siRNA delivery, with high stability, tumor-specific targeting and long circulation time.

    • Chang Xue
    • , Shuyao Hu
    •  & Zai-Sheng Wu