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Development and evaluation of a colorimetric LAMP-based biosensor for rapid detection of a nosocomial infection agent, Citrobacter freundii
- Hamidreza Mollasalehi
- , Faezeh Esmaili
- & Dariush Minai-Tehrani
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| Open Access
CHEK2 is a potential prognostic biomarker associated with immune infiltration in clear cell renal cell carcinoma
- Qihang Wu
- , Cheng Fang
- & Guobin Weng
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Latent inter-organ mechanism of idiopathic pulmonary fibrosis unveiled by a generative computational approach
- Satoshi Kozawa
- , Kengo Tejima
- & Thomas N. Sato
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Aerobic exercise training mitigates tumor growth and cancer-induced splenomegaly through modulation of non-platelet platelet factor 4 expression
- Gabriel C. Tobias
- , João L. P. Gomes
- & Patricia C. Brum
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Association of serum phosphate and changes in serum phosphate with 28-day mortality in septic shock from MIMIC-IV database
- Wenbin Nan
- , Qiong Huang
- & Zhenyu Peng
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Metabolomic profile of acute myeloid leukaemia parallels of prognosis and response to therapy
- Lukasz Bolkun
- , Tomasz Pienkowski
- & Michal Ciborowski
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A bead-based multiplex assay covering all coronaviruses pathogenic for humans for sensitive and specific surveillance of SARS-CoV-2 humoral immunity
- Daniel Stern
- , Tanja C. Meyer
- & Brigitte G. Dorner
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Assessment of interobserver concordance in radiomic tools for lung nodule classification, with a focus on BRODERS and SILA
- Faysal Al-Ghoula
- , Khushbu Patel
- & Tobias Peikert
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Circulating miRNA profiles in COVID-19 patients and meta-analysis: implications for disease progression and prognosis
- Liangliang Gao
- , Espoir M. Kyubwa
- & Naresh Menon
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A machine learning approach toward automating spatial identification of LAG3+/CD3+ cells in ulcerative colitis
- Edward D. Bonnevie
- , Eric Dobrzynski
- & David L. Krull
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HER2 low expression breast cancer subtyping and their correlation with prognosis and immune landscape based on the histone modification related genes
- Jia Li
- , Jingchun Yao
- & Liqiang Qi
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Gankyrin inhibits ferroptosis through the p53/SLC7A11/GPX4 axis in triple-negative breast cancer cells
- Ming Lei
- , Yun-Long Zhang
- & Wu-Ping Zheng
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High-throughput ligand profile characterization in novel cell lines expressing seven heterologous insect olfactory receptors for the detection of volatile plant biomarkers
- Katalin Zboray
- , Adam V. Toth
- & Peter Lukacs
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Phenotyping EMT and MET cellular states in lung cancer patient liquid biopsies at a personalized level using mass cytometry
- Loukia G. Karacosta
- , Danny Pancirer
- & Sylvia K. Plevritis
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Behavioral and physiological fatigue-related factors influencing timing and force control learning in pianists
- Mitsuaki Takemi
- , Mai Akahoshi
- & Shinichi Furuya
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Editorial
| Open AccessLiquid biopsy: from concept to clinical application
The diagnosis and treatment of cancer presents a physical and mental burden to the patient, often involving diagnostic biopsies and surgeries or chemotherapeutic approaches with severe side-effects. Advances which enable early detection of cancer and close monitoring of the disease course without invasive procedures, and which can underpin a tailored approach to treatment, can therefore make a big difference to the quality of life of patients. Liquid biopsies can be used to access tumor cells and tumor DNA circulating in the blood. Monitoring these species can provide a minimally invasive and repeatable means to detect cancer, or gain information about its response to treatment.
- Catherine Alix-Panabières
- , Dario Marchetti
- & Julie E. Lang
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Utility of heparin-binding protein following cardiothoracic surgery using cardiopulmonary bypass
- Emilia Johannesson
- , Clara Erixon
- & Igor Zindovic
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A novel biomarker of MMP-cleaved cartilage intermediate layer protein-1 is elevated in patients with rheumatoid arthritis, ankylosing spondylitis and osteoarthritis
- Helena Port
- , Cecilie Møller Hausgaard
- & Signe Holm Nielsen
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Effect of miR-206 on lower limb ischemia–reperfusion injury in rat and its mechanism
- Hui Wang
- , Meng-Jie Shi
- & Rui-Peng Zhang
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Detection of APP gene recombinant in human blood plasma
- Shigeki Mitsunaga
- , Naoko Fujito
- & Ituro Inoue
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Pattern recognition of forced oscillation technique measurement results using deep learning can identify asthmatic patients more accurately than setting reference ranges
- Chiune Funaita
- , Wakaba Furuie
- & Yuki Sumi
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Inflammatory response in mouse lungs to haze episodes under different backgrounds of particulate matter exposure
- Yuanhang Zhang
- , Yuteng Zhang
- & Xuemei Liu
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Circadian rhythm and circulating cell-free DNA release on healthy subjects
- Geoffroy Poulet
- , Jean-Sébastien Hulot
- & Valerie Taly
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Article
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Identification of a cancer associated fibroblasts-related index to predict prognosis and immune landscape in ovarian cancer
- Yingquan Ye
- , Shuangshuang Zhang
- & Mei Zhang
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Article
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Variation in presepsin and thrombomodulin levels for predicting COVID-19 mortality
- Azusa Yamazaki
- , Yoko Nukui
- & Ryunosuke Ohkawa
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Article
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Early brain microstructural development among preterm infants requiring caesarean section versus those delivered vaginally
- Pratheek S. Bobba
- , Clara F. Weber
- & Seyedmehdi Payabvash
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Article
| Open Access
Asthma control and sputum eosinophils in adult patients: a cross-sectional study in southern Brazil
- Vanessa Albano Barcellos
- , Vanessa Cristina Hartmann dos Santos
- & Paulo de Tarso Roth Dalcin
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Article
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Correlation between dynamic contrast-enhanced MRI characteristics and apparent diffusion coefficient with Ki-67-positive expression in non-mass enhancement of breast cancer
- Tingting Nie
- , Mengwei Feng
- & Gen Yan
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Article
| Open Access
Pigment epithelium-derived factor (PEDF) represses the glucose transporter 1 (GLUT1) mRNA expression and may be a potential therapeutic agent in psoriasis: a case–control and experimental study
- Khalid M. Mohany
- , Sherouk Elkady
- & Naglaa Kamal Idriss
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Article
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Gene expression alterations predict the pathological complete response in triple-negative breast cancer exploratory analysis of the NACATRINE trial
- Ana Julia Aguiar Freitas
- , Caroline Rocha Nunes
- & Márcia Maria Chiquitelli Marques
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Article
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The lactate response to a second bout of exercise is not reduced in a concurrent lower-limb exercise program
- Hayato Tsukamoto
- , Tadashi Suga
- & Takeshi Hashimoto
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Article
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The association between homocysteine and bacterial vaginosis: results from NHANES 2001–2004
- Jing Luo
- , Tong Chen
- & Xu-Guang Guo
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Article
| Open Access
Development and validation of a blood routine-based extent and severity clinical decision support tool for ulcerative colitis
- Hongliang Chen
- , Xindi Lin
- & Shizhu Jin
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Article
| Open Access
Identification and validation of a T cell marker gene-based signature to predict prognosis and immunotherapy response in gastric cancer
- Jinlin Zhong
- , Rongling Pan
- & Zhigang Huang
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Article
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Ratios of monocytes and neutrophils to lymphocytes in the blood predict benefit of CDK4/6 inhibitor treatment in metastatic breast cancer
- Stefanos Ioannis Moukas
- , Sabine Kasimir-Bauer
- & Corinna Keup
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Article
| Open Access
Determinants of exposure to acrylamide in European children and adults based on urinary biomarkers: results from the “European Human Biomonitoring Initiative” HBM4EU participating studies
- Sandra F. Fernández
- , Michael Poteser
- & Laguzzi Federica
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Lactate dehydrogenase and hemolysis index to predict vaso-occlusive crisis in sickle cell disease
- Guillaume Feugray
- , Cécile Dumesnil
- & Paul Billoir
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Comparison of the TEMPO binocular perimeter and Humphrey field analyzer
- Takashi Nishida
- , Robert N. Weinreb
- & Sasan Moghimi
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Article
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Detection of NTRK fusions by RNA-based nCounter is a feasible diagnostic methodology in a real-world scenario for non-small cell lung cancer assessment
- Rodrigo de Oliveira Cavagna
- , Edilene Santos de Andrade
- & Rui Manuel Reis
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A novel multiplex biomarker panel for profiling human acute and chronic kidney disease
- Logan R. Van Nynatten
- , Michael R. Miller
- & Douglas D. Fraser
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Family history, socioeconomic factors, comorbidities, health behaviors, and the risk of sudden cardiac arrest
- Eujene Jung
- , Jeong Ho Park
- & Ju Ok Park
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Article
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Simplified assessment of castration-induced pain in pigs using lower complexity algorithms
- Gustavo Venâncio da Silva
- , Giovana Mancilla Pivato
- & Pedro Henrique Esteves Trindade
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Article
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Residual serum fibrinogen as a universal biomarker for all serotypes of Myasthenia gravis
- Faraz S. Hussain
- , Ramanaguru S. Piragasam
- & Zaeem A. Siddiqi
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Article
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Seropositivity of Borrelia burgdorferi s.l. in Germany—an analysis across four German National Cohort (NAKO) study sites
- Max J. Hassenstein
- , Tobias Pischon
- & Stefanie Castell
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Insufficient sleep and weekend recovery sleep: classification by a metabolomics-based machine learning ensemble
- Marie Gombert
- , Nichole Reisdorph
- & Christopher M. Depner
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Article
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Comprehensive analysis of necroptotic patterns and associated immune landscapes in individualized treatment of skin cutaneous melanoma
- Bo Yang
- , Pan Xie
- & Junpeng Li
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Relationship between klotho and physical function in healthy aging
- Eliott Arroyo
- , Cecilia A. Leber
- & Kenneth Lim
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Article
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A longitudinal study of the association of epidural anesthesia and low-dose synthetic oxytocin regimens with breast milk supply and breastfeeding rates
- Kaori Takahata
- , Shigeko Horiuchi
- & Takuya Shuo
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Extraction-free LAMP assays for generic detection of Old World Orthopoxviruses and specific detection of Mpox virus
- Zhiru Li
- , Amit Sinha
- & Clotilde K. S. Carlow
Short-term variations in trabecular bone texture parameters associated to radio-clinical biomarkers improve the prediction of radiographic knee osteoarthritis progression