Bioluminescence imaging

Bioluminescence imaging (BLI) is a technology that uses light emitted by enzyme-catalyzed reactions to report activity at the molecular level. Bioluminescent reporters require a small chemical substrate for non-invasive imaging in cell biology and small animal studies. BLI does not require incident light like fluorescence or phosphorescence, avoiding phototoxicity.

Latest Research and Reviews

News and Comment

  • News & Views |

    Ten years ago, the engineering of a small luciferase called NanoLuc broke through a common limitation of bioluminescence. Currently the brightest known bioluminescent protein, NanoLuc’s activity has been used across a huge application range — enabling measurements in single cells and in whole living organisms.

    • Takeharu Nagai
    •  & Mitsuru Hattori
  • News & Views |

    Emerging data reveal that amyloid fibrils possess intrinsic photonic activity, showing luminescence over a wide range of the electromagnetic spectrum from the ultraviolet to the near-infrared.

    • Per Hammarström
    Nature Photonics 13, 442-444