Biologics articles from across Nature Portfolio

A biologic is a therapeutic substance that is produced through a biological process (often involving biotechnology methods), rather than chemical synthesis (as for traditional pharmaceuticals). Types of biologic include antibody therapies, vaccines, gene therapies and cell therapies.

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Synthetic cationic helical polypeptides for the stimulation of antitumour innate immune pathways in antigen-presenting cells

The hydrophobicity, electrostatic charge and secondary conformation of helical polypeptides can be optimized to stimulate antitumour innate immune responses via endoplasmic reticulum stress in antigen-presenting cells.
- DaeYong Lee
- Kristin Huntoon
- Betty Y. S. Kim
Research19 Apr 2024 Nature Biomedical Engineering
P: 1-18
Triple tandem trimer immunogens for HIV-1 and influenza nucleic acid-based vaccines
- Iván del Moral-Sánchez
- Edmund G. Wee
- Rogier W. Sanders
ResearchOpen Access06 Apr 2024 npj Vaccines
Volume: 9, P: 74
VISTA checkpoint inhibition by pH-selective antibody SNS-101 with optimized safety and pharmacokinetic profiles enhances PD-1 response

VISTA is a pH-dependent inhibitory checkpoint for T-cells that is abundant on myeloid lineage cells and antagonists of VISTA may successfully reinvigorate anti-tumour immunity. Here, the authors show that the antibody SNS-101, which is currently being investigated in humans in a clinical trial, is characterized by pH-sensitivity that endows it with favorable pharmacokinetic and safety profiles, and enhanced therapeutic effect when combined with PD-1 checkpoint inhibitors.
- Thomas Thisted
- F. Donelson Smith
- Edward H. van der Horst
ResearchOpen Access04 Apr 2024 Nature Communications
Volume: 15, P: 2917
Reverse development of vaccines against antimicrobial-resistant pathogens
- Fabio Bagnoli
- Ilaria Galgani
- Sanjay Phogat
ReviewsOpen Access03 Apr 2024 npj Vaccines
Volume: 9, P: 71
Autologous cell transplantation for treatment of colorectal aganglionosis in mice

Neurointestinal diseases cause significant morbidity and effective treatments are lacking. Here, authors perform autologous cell transplantation of enteric neural stem cells in a mouse model of colonic aganglionosis and report restoration of colonic contractile activity.
- Weikang Pan
- Ahmed A. Rahman
- Ryo Hotta
ResearchOpen Access20 Mar 2024 Nature Communications
Volume: 15, P: 2479
Design of amyloidogenic peptide traps

An approach to design proteins that can capture amyloidogenic protein regions present in, for example, tau and Aβ42 has now been developed. These designer proteins can inhibit the formation of pathogenic amyloid fibrils and protect cells from toxic species.
- Danny D. Sahtoe
- Ewa A. Andrzejewska
- David Baker
ResearchOpen Access19 Mar 2024 Nature Chemical Biology
P: 1-10