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Open Access
Featured
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Technology Feature |
One year, three researchers, millions of cells: how a small team created the largest mouse-embryo atlas so far
A map of mouse development from conception to birth tracks 12.4 million cells at single-cell resolution as they mature into organs and other tissues.
- Sara Reardon
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News & Views |
Powerful microscopy reveals blood-cell production in bone marrow
A method for imaging the production of blood cells in the bones of mice has revealed the organization of cell lineages, both in a steady state and in response to stressors, such as bleeding and infection.
- M. Carolina Florian
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Nature Video |
Building a heart atlas: researchers map organ in stunning detail
Cutting edge imaging techniques reveal how cells organise as the heart develops.
- Dan Fox
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Nature Index |
Four change-makers seek impact in medical research
Bringing fresh perspectives to long-standing health challenges, these scientists are using techniques such as big-data analytics and AI to push the field.
- Amy Coombs
- & Sandy Ong
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Article |
Universal recording of immune cell interactions in vivo
A paper reports the development of a universal tool for studying cellular interactions in biological systems, and demonstrates its coupling with single-cell transcriptomics methods to provide insights into the biology of the interactions.
- Sandra Nakandakari-Higa
- , Sarah Walker
- & Gabriel D. Victora
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Technology Feature |
How phase separation is revolutionizing biology
Imaging and molecular manipulation reveal how biomolecular condensates form and offer clues to the role of phase separation in health and disease.
- Elie Dolgin
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News |
MEGA-CRISPR tool gives a power boost to cancer-fighting cells
A system that edits RNA rather than DNA can give new life to exhausted CAR T cells.
- Sara Reardon
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Technology Feature |
Super-speedy sequencing puts genomic diagnosis in the fast lane
Streamlined workflows for DNA and RNA sequencing are helping clinicians to deliver prompt, targeted care to people in days — or even hours.
- Michael Eisenstein
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News |
Move over, CRISPR: RNA-editing therapies pick up steam
Two RNA-editing therapies for genetic diseases have in the past few months gained approval for clinical trials, raising hopes for safer treatments.
- Mariana Lenharo
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Article
| Open AccessGenetic determinants of micronucleus formation in vivo
Genetic screening identifies a rich catalogue of regulators of micronucleus formation.
- D. J. Adams
- , B. Barlas
- & G. Balmus
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News |
Turbocharged CAR-T cells melt tumours in mice — using a trick from cancer cells
Immune cells armed with a mutation first identified in cancer cells gain potency but don’t turn cancerous themselves.
- Asher Mullard
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Article
| Open AccessSingle-neuronal elements of speech production in humans
Neuropixels recordings from the language-dominant prefrontal cortex reveal a structured organization of planned words, an encoding cascade of phonetic representations by prefrontal neurons in humans and a cellular process that could support the production of speech.
- Arjun R. Khanna
- , William Muñoz
- & Ziv M. Williams
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News |
‘Wildly weird’ RNA bits discovered infesting the microbes in our guts
Rod-shaped structures named ‘obelisks’ are even smaller than viruses but can still transmit instructions to cells.
- Saima Sidik
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Outlook |
Tracking down tuberculosis
Improvements in screening and diagnosis could help to eradicate this curable disease.
- Neil Savage
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News |
CRISPR-edited crops break new ground in Africa
Scientists in the global south use the popular technique to protect local crops against local threats.
- Heidi Ledford
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Technology Feature |
Seven technologies to watch in 2024
Advances in artificial intelligence are at the heart of many of this year’s most exciting areas of technological innovation
- Michael Eisenstein
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Article
| Open AccessDeciphering cell states and genealogies of human haematopoiesis
An improved, single-cell lineage-tracing system, based on deep detection of naturally occurring mitochondrial DNA mutations with simultaneous readout of transcriptional states and chromatin accessibility, is used to define the clonal architecture of haematopoietic stem cells.
- Chen Weng
- , Fulong Yu
- & Vijay G. Sankaran
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Article
| Open AccessAffinity-optimizing enhancer variants disrupt development
Low-affinity transcription factor binding sites are prevalent across the genome, and single nucleotide changes that increase binding affinity even slightly can cause gain-of-function gene expression and phenotypes (such as polydactyly).
- Fabian Lim
- , Joe J. Solvason
- & Emma K. Farley
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Article
| Open AccessDe novo design of high-affinity binders of bioactive helical peptides
A study describes a direct computational approach without experimental optimization to design high-affinity proteins that bind small helical peptides.
- Susana Vázquez Torres
- , Philip J. Y. Leung
- & David Baker
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News & Views |
Gene expression of single cells mapped in tissue sections
A tool that tags individual cells in a tissue with a unique barcode means that the gene-expression profile of each cell can be plotted in its original location. This allows spatial information to be captured at single-cell resolution.
- Patrik L. Ståhl
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News |
Australian Indigenous genomes are highly diverse and unlike those anywhere else
In collecting genomic data for Indigenous Australians, scientists hope to expand knowledge of human genetic diversity and improve health for this group.
- Bianca Nogrady
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Article
| Open AccessSlide-tags enables single-nucleus barcoding for multimodal spatial genomics
Slide-tags enables multiomic sequencing of single cells and their localization within tissues.
- Andrew J. C. Russell
- , Jackson A. Weir
- & Fei Chen
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News |
How CRISPR gene editing could help treat Alzheimer’s
Some researchers hoping that gene-editing technology can conquer forms of Alzheimer’s caused by genetic mutations.
- Tosin Thompson
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News |
CRISPR 2.0: a new wave of gene editors heads for clinical trials
Landmark approval of the first CRISPR therapy paves the way for treatments based on more efficient and more precise genome editors.
- Heidi Ledford
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Research Briefing |
Atomic-level structures show how accuracy is maintained in protein synthesis
A series of structures of the eukaryotic protein-synthesis machinery are imaged at high resolution in defined states of the elongation phase of protein synthesis. Analysis suggests that there are underlying molecular mechanisms that increase the accuracy of translation of genetic information in eukaryotes.
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Technology Feature |
AI under the microscope: the algorithms powering the search for cells
Deep learning is driving the rapid evolution of algorithms that can automatically find and trace cells in a wide range of microscopy experiments.
- Michael Eisenstein
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Nature Video |
The 3D printer that crafts complex robotic organs in a single run
Combining machine vision with contactless error correction allows for even more advanced multi-material printing.
- Dan Fox
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Article
| Open AccessThe social and structural architecture of the yeast protein interactome
A protein interaction network constructed with data from high-throughput affinity enrichment coupled to mass spectrometry provides a highly saturated yeast interactome with 31,004 interactions, including low-abundance complexes, membrane protein complexes and non-taggable protein complexes.
- André C. Michaelis
- , Andreas-David Brunner
- & Matthias Mann
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Article
| Open AccessEmbryo-scale reverse genetics at single-cell resolution
We present the ‘zebrafish single-cell atlas of perturbed embryos’, single-cell trancriptomic data of developing zebrafish embryos across various timepoints and with genetic perturbations.
- Lauren M. Saunders
- , Sanjay R. Srivatsan
- & Cole Trapnell
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News & Views |
The deep route to low-field MRI with high potential
A type of magnetic resonance imaging, known as low-field MRI, could make the technique more widely accessible, but only if the image quality can be improved. A deep-learning protocol might hold the key.
- Patricia M. Johnson
- & Yvonne W. Lui
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News |
New explanation for infertility: eggs lacking a mysterious ‘lattice’
The discovery of a ‘storage locker’ for essential proteins could explain some cases of infertility.
- Gayathri Vaidyanathan
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Article
| Open AccessNeural signal propagation atlas of Caenorhabditis elegans
Measurements of signal propagation in more than 23,000 pairs of neurons from nematode worms show that predictions of neural function made on the basis of anatomy are often incorrect, in part owing to the effects of extrasynaptic signalling.
- Francesco Randi
- , Anuj K. Sharma
- & Andrew M. Leifer
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News Explainer |
Is CRISPR safe? Genome editing gets its first FDA scrutiny
Advisers to the US regulatory agency will examine the safety profile of a CRISPR-based treatment for sickle-cell disease.
- Heidi Ledford
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Article
| Open AccessA microfluidic transistor for automatic control of liquids
Flow limitation is exploited to develop a microfluidic device exhibiting flow–pressure behaviour analogous to the current–voltage characteristics of an electronic transistor.
- Kaustav A. Gopinathan
- , Avanish Mishra
- & Mehmet Toner
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Editorial |
How to share data — not just equally, but equitably
Just as with many natural resources, wealthy countries have been extracting scientific data from poorer nations for centuries. Researchers are changing that.
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Technology Feature |
Soft-landing methods aim to simplify structural biology
Linking mass spectrometry with cryo-electron microscopy could transform understanding of complex protein structures — if scientists can show that samples remain intact when they hit their target.
- Michael Eisenstein
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Career Column |
Methods section too short? Use online protocols to make complex techniques understandable
New wet-lab methods can be hard to share owing to their complexity, but with a little extra effort, you can give users a leg-up in getting started.
- Lars Borm
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News |
Monkey survives for two years after gene-edited pig-kidney transplant
Survival time is one of the longest for any interspecies transplant — and moves pig organs closer to human use.
- Max Kozlov
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Article
| Open AccessUltra-fast deep-learned CNS tumour classification during surgery
Sturgeon is a pretrained neural network that uses incremental results from nanopore sequencing to rapidly classify central nervous system tumours and can be used to aid critical decision-making during surgery.
- C. Vermeulen
- , M. Pagès-Gallego
- & J. de Ridder
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Career Guide |
How to spice up your bioinformatics skill set with AI
Incorporating machine-learning tools into data analysis can accelerate discovery and free up valuable time.
- Rachael Pells
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Career Column |
Embracing the command line: my unexpected career in computational biology
A crash course in bioinformatics put Ming Tommy Tang on a different path.
- Ming Tommy Tang
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Perspective |
The status of the human gene catalogue
Although the catalogue of human protein-coding genes is nearing completion, the number of non-coding RNA genes remains highly uncertain, and for all genes much work remains to be done to understand their functions.
- Paulo Amaral
- , Silvia Carbonell-Sala
- & Steven L. Salzberg
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Article
| Open AccessLarge-scale plasma proteomics comparisons through genetics and disease associations
Comparisons of phenotypic and genetic association with protein levels from Icelandic and UK Biobank cohorts show that using multiple analysis platforms and stratifying populations by ancestry improves the detection of associations and allows the refinement of their location within the genome.
- Grimur Hjorleifsson Eldjarn
- , Egil Ferkingstad
- & Kari Stefansson
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Technology Feature |
How open-source software could finally get the world’s microscopes speaking the same language
A plethora of standards mean shareable and verifiable microscopy data often get lost in translation. Biologists are working on a solution.
- Michael Brooks
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Article
| Open AccessProteome census upon nutrient stress reveals Golgiphagy membrane receptors
A proteomics analysis demonstrates that, during nutrient stress, mammalian cells prioritize degradation by autophagy of membrane proteins and identifies receptors that mediate this process at the Golgi and also have a role in Golgi remodelling during neuronal differentiation.
- Kelsey L. Hickey
- , Sharan Swarup
- & J. Wade Harper
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News Explainer |
How Dolly the sheep’s legacy lives on: CRISPR cattle and cloned camels
Dolly-style animal cloning underpins CRISPR livestock, but changes loom for the field.
- Heidi Ledford
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Research Briefing |
Using CRISPR to study gene function aids understanding of 22q11.2 deletion syndrome
Most high-throughput assays to investigate the role of genes in disease involve in vitro cell models. Now a technology that targets CRISPR–Cas9 gene editing to specific cells in mice, and analyses transcriptional effects in single nuclei, has led to fresh insights into the genes involved in 22q11.2 deletion syndrome.
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Article
| Open AccessTransgenic ferret models define pulmonary ionocyte diversity and function
Conditional genetic ferret models enable ionocyte lineage tracing, ionocyte ablation and ionocyte-specific deletion of CFTR to elucidate the roles of pulmonary ionocyte biology and function during human health and disease.
- Feng Yuan
- , Grace N. Gasser
- & John F. Engelhardt
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Article
| Open AccessTranscriptional linkage analysis with in vivo AAV-Perturb-seq
An in vivo single-cell CRISPR screening method identifies transcriptional phenotypes of 22q11.2 deletion syndrome associated with a broad dysregulation of a class of disease susceptibility genes that are important for RNA processing and synaptic function.
- Antonio J. Santinha
- , Esther Klingler
- & Randall J. Platt
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