Biological sciences

Definition

Biological sciences encompasses all the divisions of natural sciences examining various aspects of vital processes. The concept includes anatomy, physiology, cell biology, biochemistry and biophysics, and covers all organisms from microorganisms, animals to plants.

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Latest Research and Reviews

  • Research |

    Epelman and colleagues use fate mapping and single-cell transcriptomics to describe the dynamics of resident and recruited cardiac macrophages during ischemic injury.

    • Sarah A. Dick
    • , Jillian A. Macklin
    • , Sara Nejat
    • , Abdul Momen
    • , Xavier Clemente-Casares
    • , Marwan G. Althagafi
    • , Jinmiao Chen
    • , Crystal Kantores
    • , Siyavash Hosseinzadeh
    • , Laura Aronoff
    • , Anthony Wong
    • , Rysa Zaman
    • , Iulia Barbu
    • , Rickvinder Besla
    • , Kory J. Lavine
    • , Babak Razani
    • , Florent Ginhoux
    • , Mansoor Husain
    • , Myron I. Cybulsky
    • , Clinton S. Robbins
    •  & Slava Epelman
    Nature Immunology 20, 29–39
  • Reviews |

    The treatment of systemic lupus erythematosus involves a balance between control of disease activity and prevention of therapeutic harm that requires careful optimization. In this Review, the authors discuss available and emerging therapeutic strategies that exploit the current drug armamentarium.

    • Mariele Gatto
    • , Margherita Zen
    • , Luca Iaccarino
    •  & Andrea Doria
  • Reviews |

    This Review discusses causal germline variants in prostate cancer identified through genome-wide association studies (GWAS) and post-GWAS analyses. The latter are vital to identify causal variants and molecular mechanisms by which these variants promote prostate tumorigenesis, with potential clinical applications.

    • Samaneh Farashi
    • , Thomas Kryza
    • , Judith Clements
    •  & Jyotsna Batra
  • Research |

    • Alex W. Wilkinson
    • , Jonathan Diep
    • , Shaobo Dai
    • , Shuo Liu
    • , Yaw Shin Ooi
    • , Dan Song
    • , Tie-Mei Li
    • , John R. Horton
    • , Xing Zhang
    • , Chao Liu
    • , Darshan V. Trivedi
    • , Katherine M. Ruppel
    • , José G. Vilches-Moure
    • , Kerriann M. Casey
    • , Justin Mak
    • , Tina Cowan
    • , Joshua E. Elias
    • , Claude M. Nagamine
    • , James A. Spudich
    • , Xiaodong Cheng
    • , Jan E. Carette
    •  & Or Gozani
  • Research | | open

    Activation of PI3K plays a role in pulmonary inflammation. Here, the authors develop a drug inhibitor of PI3K, and show that it inhibits lung inflammation and damage in mouse models of asthma and lung fibrosis.

    • Carlo C. Campa
    • , Rangel L. Silva
    • , Jean P. Margaria
    • , Tracey Pirali
    • , Matheus S. Mattos
    • , Lucas R. Kraemer
    • , Diego C. Reis
    • , Giorgio Grosa
    • , Francesca Copperi
    • , Eduardo M. Dalmarco
    • , Roberto C. P. Lima-Júnior
    • , Silvio Aprile
    • , Valentina Sala
    • , Federica Dal Bello
    • , Douglas Silva Prado
    • , Jose Carlos Alves-Filho
    • , Claudio Medana
    • , Geovanni D. Cassali
    • , Gian Cesare Tron
    • , Mauro M. Teixeira
    • , Elisa Ciraolo
    • , Remo C. Russo
    •  & Emilio Hirsch
  • Research | | open

    Hongnan Cao et al. present the X-ray crystal structure of E. coli dihydrofolate reductase (DHFR) in complex with its reduced substrate, (6s)-5,6,7,8-tetrahydrofolate (FH4). This structure provides the first glimpse of the rate-limiting product release step of the DHFR mechanism and suggests a strategy for designing DHFR-targeting antibiotics.

    • Hongnan Cao
    • , Mu Gao
    • , Hongyi Zhou
    •  & Jeffrey Skolnick

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