Biological sciences

Biological sciences encompasses all the divisions of natural sciences examining various aspects of vital processes. The concept includes anatomy, physiology, cell biology, biochemistry and biophysics, and covers all organisms from microorganisms, animals to plants.

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News & Views | 08 February 2023

An oracle predicts regulators of cell identity
- Jeffrey A. Farrell
Nature
News & Views | 08 February 2023

How rare mutations contribute to complex traits
- Luke M. Evans
- & Pamela N. Romero Villela
Nature
News & Views | 08 February 2023

The brain’s encoding of warm and cool

Nature

Latest Research and Reviews

Research | 08 February 2023

The structural basis for HIV-1 Vif antagonism of human APOBEC3G
- Yen-Li Li
- , Caroline A. Langley
- & John D. Gross
Nature, 1-3
Research
08 February 2023 | Open Access

Targeting BAP1 with small compound inhibitor for colon cancer treatment
- Minhwa Kang
- , Seul Gi Park
- & Jongbum Kwon
Scientific Reports 13, 2264
Research
08 February 2023 | Open Access

A mechanistic evaluation of human beta defensin 2 mediated protection of human skin barrier in vitro
- Jennifer R. Shelley
- , Brian J. McHugh
- & Donald J. Davidson
Scientific Reports 13, 2271
Reviews | 08 February 2023

Can we predict T cell specificity with digital biology and machine learning?

Koohy and co-workers discuss how we must turn to machine-learning approaches to define the antigen specificity of the many millions of possible T cell receptors. They review the models and methods currently being used to predict cognate antigens for orphan T cell receptors.
- Dan Hudson
- , Ricardo A. Fernandes
- & Hashem Koohy
Nature Reviews Immunology, 1-11
Reviews | 08 February 2023

Metals to combat antimicrobial resistance

Metals and their complexes with antimicrobial activity are a promising source of new antibiotics. Their 3D geometry and potential for multiple mechanisms of action are important assets; however, a substantial investment in research is needed to advance them to the clinic.
- Angelo Frei
- , Anthony D. Verderosa
- & Mark A. T. Blaskovich
Nature Reviews Chemistry, 1-23
Research | 08 February 2023

An E1–E2 fusion protein primes antiviral immune signalling in bacteria

This study demonstrates that bacteria use a ubiquitin transferase-like enzyme to prime cGAS/DncV-like nucleotidyltransferase activation and use a deubiquitinase-like enzyme to decrease activity.
- Hannah E. Ledvina
- , Qiaozhen Ye
- & Aaron T. Whiteley
Nature, 1-7

All Research & Reviews

News and Comment

Research Highlights | 08 February 2023

LAP1 squeezes out ahead

In this study, Jung-Garcia et al. use in vitro and in vivo modelling to demonstrate the role of LAP1 in promoting melanoma cell invasion and highlight its link to metastatic dissemination.
- Gabrielle Brewer
Nature Reviews Cancer, 1
Comments & Opinion
08 February 2023 | Open Access

Rewilding abandoned farmland has greater sustainability benefits than afforestation

Expansive farmlands in Europe and elsewhere are either already abandoned or projected to become abandoned. Afforestation on these abandoned farmlands is highly popular, but it only addresses the climate crisis, not the biodiversity emergency. An alternative to afforestation is rewilding, which would contribute to combating both the biodiversity and climate crises while also facilitating socio-ecological sustainability by increasing ecosystem resilience.
- Lanhui Wang
- , Pil Birkefeldt Møller Pedersen
- & Jens-Christian Svenning
npj Biodiversity 2, 5
Research Highlights | 08 February 2023

Noise shatters deep sleep thanks to dedicated brain circuit

Neurons that help to rouse you from sound slumber are connected to those that receive signals from the spinal cord.

Nature
Research Highlights | 08 February 2023

Discontinuation of infliximab in patients with Crohn’s disease on combination therapy
- Jordan Hindson
Nature Reviews Gastroenterology & Hepatology, 1
Research Highlights | 08 February 2023

Co-extinctions dominate losses
- Tegan Armarego-Marriott
Nature Climate Change, 1
Research Highlights | 08 February 2023

Physical-exercise intervention effective in frail older adults with heart failure
- Yahyah Aman
Nature Aging, 1

All News & Comment

Biological sciences

Featured

An oracle predicts regulators of cell identity

How rare mutations contribute to complex traits

The brain’s encoding of warm and cool

Latest Research and Reviews

The structural basis for HIV-1 Vif antagonism of human APOBEC3G

Targeting BAP1 with small compound inhibitor for colon cancer treatment

A mechanistic evaluation of human beta defensin 2 mediated protection of human skin barrier in vitro

Can we predict T cell specificity with digital biology and machine learning?

Metals to combat antimicrobial resistance

An E1–E2 fusion protein primes antiviral immune signalling in bacteria

News and Comment

LAP1 squeezes out ahead

Rewilding abandoned farmland has greater sustainability benefits than afforestation

Noise shatters deep sleep thanks to dedicated brain circuit

Discontinuation of infliximab in patients with Crohn’s disease on combination therapy

Co-extinctions dominate losses

Physical-exercise intervention effective in frail older adults with heart failure

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Biological sciences

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