Featured
-
-
Article
| Open AccessMultiscale architecture design of 3D printed biodegradable Zn-based porous scaffolds for immunomodulatory osteogenesis
Rapid degradation inducing overdose toxicity remains challenging in porous biodegradable bone scaffolds. Here the authors present multiscale architecture design on ZnLi scaffolds with 90% porosity orchestrates immune responses and subsequent bone regeneration.
- Shuang Li
- , Hongtao Yang
- & Yufeng Zheng
-
Article
| Open AccessContrasting carbon cycle along tropical forest aridity gradients in West Africa and Amazonia
This study finds that West African ecosystems are generally more productive than equivalent ecosystems in Amazonia. It also suggests that a semi-deciduous forest site in Ghana is the world’s most productive forest measured to date.
- Huanyuan Zhang-Zheng
- , Stephen Adu-Bredu
- & Yadvinder Malhi
-
Article
| Open AccessCell-type-specific mRNA transcription and degradation kinetics in zebrafish embryogenesis from metabolically labeled single-cell RNA-seq
This study analyzes the embryonic replacement of maternally contributed mRNA with new mRNA in single cells and shows dynamic spatio-temporal regulation of maternal mRNA decay and cell-type specific retention within the earliest specified cell types in zebrafish embryos.
- Lior Fishman
- , Avani Modak
- & Michal Rabani
-
Article
| Open AccessVaccination impairs de novo immune response to omicron breakthrough infection, a precondition for the original antigenic sin
Immune imprinting can affect the response to future infection with pathogen variants. Here, Pušnik et. al. demonstrate that previous vaccination with wild-type SARS-CoV-2 vaccine hampers the formation of an immune response to mutated regions of omicron surface proteins following omicron breakthrough infection.
- Jernej Pušnik
- , Jasmin Zorn
- & Hendrik Streeck
-
Article
| Open AccessFuzzy recognition by the prokaryotic transcription factor HigA2 from Vibrio cholerae
Here, the authors dissect the fuzzy interaction between the prokaryote transcription factor HigA2 and its DNA target and show that specific, transient interactions drive specificity despite HigA2 remaining mostly disordered.
- San Hadži
- , Zala Živič
- & Remy Loris
-
Article
| Open AccessAllopolyploid origin and diversification of the Hawaiian endemic mints
Hawaiian endemic mints represent the second largest plant radiation in the archipelago. Here, the authors present a reference genome and numerous resequenced individuals to uncover evidence for polyploidy, geographic speciation and localized hybridization underlying diversification in this lineage
- Crystal M. Tomlin
- , Sitaram Rajaraman
- & Charlotte Lindqvist
-
Article
| Open AccessA subgroup of light-driven sodium pumps with an additional Schiff base counterion
Light-driven sodium-pumping rhodopsins are unique ion transporters. Here, authors present a characterization of such rhodopsins with a modified active center allowing for efficient sodium transport under various environmental conditions.
- E. Podoliak
- , G. H. U. Lamm
- & K. Kovalev
-
Article
| Open AccessA membrane associated tandem kinase from wild emmer wheat confers broad-spectrum resistance to powdery mildew
Powdery mildew is a fungal leaf disease that reduces yield and grain quality in susceptible wheat varieties. Here, the authors report the cloning of the wild emmer wheat originated powdery mildew resistance gene Pm36 as a membrane associated tandem kinase and its possible resistance mechanism.
- Miaomiao Li
- , Huaizhi Zhang
- & Zhiyong Liu
-
Article
| Open AccessComplex activity and short-term plasticity of human cerebral organoids reciprocally connected with axons
Connecting cerebral organoids with an axon bundle models inter-regional projections and enhances neural activity. Optogenetic stimulation induces short-term plasticity, offering insights into macroscopic circuit development and functionality.
- Tatsuya Osaki
- , Tomoya Duenki
- & Yoshiho Ikeuchi
-
Article
| Open AccessThylakoid protein FPB1 synergistically cooperates with PAM68 to promote CP47 biogenesis and Photosystem II assembly
The assembly of the Photosystem II proximal antenna CP47 remains a challenging question. Here the authors show that FPB1 and PAM68 act coordinately with Alb3 and the SecY/E translocon to facilitate the co-translational integration of specific regions of CP47 into thylakoids.
- Lin Zhang
- , Junxiang Ruan
- & Lianwei Peng
-
Article
| Open AccessParenchymal cues define Vegfa-driven venous angiogenesis by activating a sprouting competent venous endothelial subtype
Organs develop unique vascular architectures to support physiological functions. Here, authors show that organo-typical vascular networks may arise from specific parenchymal cues activating unique endothelial subtypes and angiogenic sprouting processes.
- Laetitia Préau
- , Anna Lischke
- & Ferdinand le Noble
-
Article
| Open AccessEarly-life exercise induces immunometabolic epigenetic modification enhancing anti-inflammatory immunity in middle-aged male mice
Exercise could affect the immune system, but whether early-life exercise could benefit immune health in adulthood is not fully understood. Here the authors show that early-life exercise promotes epi-metabolic changes in the liver to potentially benefit immunity in older age and characterise the involvement of pipecolic acid in this process.
- Nini Zhang
- , Xinpei Wang
- & Feng Gao
-
Article
| Open AccessMultiple processes of vocal sensory-motor interaction in primate auditory cortex
The neural processes underlying vocal self-monitoring are unclear. Here, the authors show that vocal suppression of auditory cortex operates on two time-scales with different temporal and acoustic precision, suggesting distinct predictive modulations.
- Joji Tsunada
- , Xiaoqin Wang
- & Steven J. Eliades
-
Article
| Open AccessAuditory cortex conveys non-topographic sound localization signals to visual cortex
Auditory cortex sends dense projections to layer 1 of mouse V1. Here the authors show these axons convey rich sound localization signals and that their auditory receptive fields do not align with the retinotopic map of V1.
- Camille Mazo
- , Margarida Baeta
- & Leopoldo Petreanu
-
Article
| Open AccessSalmonella exploits membrane reservoirs for invasion of host cells
The plasma membrane of eukaryotic cells can fold inwards to create reservoirs that store or release excess membrane. Zhu et al. show that Salmonella-secreted effectors modulate these reservoirs to facilitate host cell invasion.
- Hongxian Zhu
- , Andrew M. Sydor
- & John H. Brumell
-
Article
| Open AccessDNA binding analysis of rare variants in homeodomains reveals homeodomain specificity-determining residues
Analysis of 92 human homeodomain mutants, including disease-associated variants and variants of uncertain significance, reveals variants with altered DNA binding affinity and/or specificity and specificity-determining positions.
- Kian Hong Kock
- , Patrick K. Kimes
- & Martha L. Bulyk
-
Article
| Open AccessIntegrated proteomics reveals autophagy landscape and an autophagy receptor controlling PKA-RI complex homeostasis in neurons
The health of brain cells is known to depend on functional autophagy, but the details are unclear. Here, the authors perform systematic proteomic profiling of human and mouse neurons, delineating the landscape of autophagy degradation in brain.
- Xiaoting Zhou
- , You-Kyung Lee
- & Zhenyu Yue
-
Article
| Open AccessElectrochemically coupled CH4 and CO2 consumption driven by microbial processes
The microbial valorisation of greenhouse gases could offer promising approaches climate change mitigation. Here, authors demonstrate the coupling of methane oxidation and carbon dioxide reduction by microbial consortia, facilitated by the redox cycling of iron minerals.
- Yue Zheng
- , Huan Wang
- & Feng Zhao
-
Article
| Open AccessGenetically encoded transcriptional plasticity underlies stress adaptation in Mycobacterium tuberculosis
Transcriptional plasticity (TP) governs gene expression variability, yet remains unexplored in prokaryotes. This study examines Mycobacterium tuberculosis genes’ TP via RNA-seq meta-analysis, uncovering genetic and functional traits impacting mycobacterial TP.
- Cheng Bei
- , Junhao Zhu
- & Qingyun Liu
-
Article
| Open AccessImmunoglobulin G N-glycan markers of accelerated biological aging during chronic HIV infection
In this study, Giron et al. find that people living with chronic HIV experience accelerated aging-associated alterations in antibody glycans. These alterations, attributed to senescence enzymes, predict comorbidities and reduce the antiviral function of antibodies.
- Leila B. Giron
- , Qin Liu
- & Mohamed Abdel-Mohsen
-
Article
| Open AccessSingle-cell and spatial RNA sequencing reveal the spatiotemporal trajectories of fruit senescence
Fruit senescence is a complex physiological process. Here, the authors construct a single-cell expression atlas of pitaya pericarp pitaya to provide a spatiotemporal perspective of the dynamic process of plant senescence.
- Xin Li
- , Bairu Li
- & Robert Henry
-
Article
| Open AccessA primary sensory cortical interareal feedforward inhibitory circuit for tacto-visual integration
Where and how the brain integrates discrete sensory inputs is not fully understood. Here authors show that a multisensory zone in the mouse anterior primary visual cortex integrates tactile and visual inputs from a shared sensory space through interareal feedforward inhibition.
- Simon Weiler
- , Vahid Rahmati
- & Manuel Teichert
-
Article
| Open AccessStructure-guided functional suppression of AML-associated DNMT3A hotspot mutations
DNMT3A R882H and R882C are mutation hotspots in acute myeloid leukemia. This study describes the structural and functional consequences of the DNMT3A R882H/R882C mutations which can provide a strategy for therapy of the disease mutations.
- Jiuwei Lu
- , Yiran Guo
- & Jikui Song
-
Article
| Open AccessRisks posed by invasive species to the provision of ecosystem services in Europe
Non-native species may pose a threat not only to native biodiversity, but also to the provision of ecosystem services. Here, the authors quantify the potential impact of invasive species on a set of ecosystem services across Europe.
- Belinda Gallardo
- , Sven Bacher
- & Montserrat Vilà
-
Article
| Open AccessAntigen-specific Fab profiling achieves molecular-resolution analysis of human autoantibody repertoires in rheumatoid arthritis
Although many autoimmune diseases are characterized by the presence of autoantibodies, complete characterisation of autoantibody repertoires is lacking. Here, the authors introduce an autoantigen-specific Fab profiling method to show that the autoantibody repertoire in rheumatoid arthritis is diverse yet dominated only by a few clones.
- Eva Maria Stork
- , Danique M. H. van Rijswijck
- & Albert Bondt
-
Article
| Open AccessThe genomic evolutionary dynamics and global circulation patterns of respiratory syncytial virus
This study on respiratory syncytial virus (RSV) reveals global genomic gaps. Using INFORM-RSV data, it uncovers selection’s impact on RSVA and RSVB diversity. Analysing full genomes, it highlights non-neutral epidemic processes. The research emphasises air travel’s influence on global spread, underscoring the need for comprehensive RSV genomic surveillance.
- Annefleur C. Langedijk
- , Bram Vrancken
- & Shabir A. Madhi
-
Article
| Open AccessA bionic self-driven retinomorphic eye with ionogel photosynaptic retina
Luo et al. report a self-driven hemispherical retinomorphic eye that employs ionogel heterojunctions as photoreceptors. This photoreceptor exhibits broadband photosynapse, high conformability, retinal transplantation, and visual restoration for re-time optical imaging and motion tracking.
- Xu Luo
- , Chen Chen
- & Wei Huang
-
Article
| Open AccessTeacher-student collaborated multiple instance learning for pan-cancer PDL1 expression prediction from histopathology slides
PDL1 expression is a common biomarker for immunotherapy response in cancer, and it is usually quantified using immunohistochemistry. Here, the authors develop a weakly supervised learning approach combining multiple instance learning and a teacher-student framework to predict PDL1 expression from histopathological imaging.
- Darui Jin
- , Shangying Liang
- & Xiangzhi Bai
-
Matters Arising
| Open AccessRectifying misinformation on the climate intervention potential of ocean afforestation
- Victor Smetacek
- , Mar Fernández-Méndez
- & Jiajun Wu
-
Article
| Open AccessLDL receptor-related protein 5 selectively transports unesterified polyunsaturated fatty acids to intracellular compartments
The mechanisms transporting fatty acids into the cell are not completely understood. Here, the authors discover a selective transporter for a specific class of lipids, and show its role in regulating neutrophil function during myocardial ischemia-reperfusion injury.
- Wenwen Tang
- , Yi Luan
- & Dianqing Wu
-
Article
| Open AccessDecoding spatiotemporal transcriptional dynamics and epithelial fibroblast crosstalk during gastroesophageal junction development through single cell analysis
Elucidating the gastroesophageal junction’s development is key to comprehending its disease susceptibility. Here, the authors mapped its development, uncovering cellular diversity and interaction dynamics using advanced spatiotemporal single-cell analysis.
- Naveen Kumar
- , Pon Ganish Prakash
- & Cindrilla Chumduri
-
Article
| Open AccessSARS-CoV-2-specific cellular and humoral immunity after bivalent BA.4/5 COVID-19-vaccination in previously infected and non-infected individuals
Prior infection or exposure to SARS-CoV-2 may influence immunogenicity and effectiveness of subsequent vaccination to new strains of virus. Here the authors show that immunogenicity of a BA.4/5 mRNA vaccine differed in recipients depending on whether they had been exposed to or infected with an earlier strain of virus.
- Rebecca Urschel
- , Saskia Bronder
- & Martina Sester
-
Article
| Open AccessAn Intricate Network Involving the Argonaute ALG-1 Modulates Organismal Resistance to Oxidative Stress
In this study, Vergani-Junior et al. show that increased expression of the argonaute ALG-1 in long-lived worms improves oxidative stress resistance through the modulation of microRNAs that downregulate the protein disulfide isomerase pathway.
- Carlos A. Vergani-Junior
- , Raíssa De P. Moro
- & Marcelo A. Mori
-
Article
| Open AccessNonlinear DNA methylation trajectories in aging male mice
DNA methylation is an age biomarker, but nonlinear aspects of its age-related dynamics are not well characterized. Here, the authors identify loci that undergo sudden methylation changes at specific life stages in the aging colon of male mice.
- Maja Olecka
- , Alena van Bömmel
- & Steve Hoffmann
-
Article
| Open AccessDHX9 maintains epithelial homeostasis by restraining R-loop-mediated genomic instability in intestinal stem cells
Inflammatory bowel disease (IBD) is featured with epithelial barrier dysfunction, however, the underlying mechanism is less clear. Here, the authors show that DHX9 deficiency in intestinal stem cells (ISCs) induces accumulation of abnormal R-loops and subsequent genomic instability, leading to impairment of ISCs and development of IBD.
- Xingxing Ren
- , Qiuyuan Liu
- & Shu Zhu
-
Article
| Open AccessPrey killing without invasion by Bdellovibrio bacteriovorus defective for a MIDAS-family adhesin
The bacterium Bdellovibrio bacteriovorus is a predator of other bacteria, invading the prey’s periplasm and forming a rounded killed cell where it replicates. Here, Tyson et al. identify a B. bacteriovorus protein that is important for successful invasion of prey, and show that prey killing can occur without invasion.
- Jess Tyson
- , Paul Radford
- & R. Elizabeth Sockett
-
Article
| Open AccessMolecular patterns of resistance to immune checkpoint blockade in melanoma
A large fraction of patients with melanoma still does not benefit from immune checkpoint blockade, associated with both primary and acquired resistance. Here the authors report genetic and immunological patterns of resistance in patients with melanoma after progression on anti-CTLA4 or anti-PD1 monotherapy.
- Martin Lauss
- , Bengt Phung
- & Göran Jönsson
-
Article
| Open AccessWorldwide divergence of values
The authors test whether social values have become converged or diverged across national cultures over the last 40 years using a 76-country analysis of the World Values Survey. They show that values have diverged, especially between high-income Western countries and the rest of the world.
- Joshua Conrad Jackson
- & Danila Medvedev
-
Article
| Open AccessExpedient production of site specifically nucleobase-labelled or hypermodified RNA with engineered thermophilic DNA polymerases
A general method for enzymatic synthesis of base-modified RNA was developed using engineered thermostable DNA polymerases enabling introduction of site-specific modifications or synthesis of hypermodified RNA not accessible by in vitro transcription.
- Mária Brunderová
- , Vojtěch Havlíček
- & Michal Hocek
-
Article
| Open AccessViability leads to the emergence of gait transitions in learning agile quadrupedal locomotion on challenging terrains
A bio-inspired control architecture for learning agile quadruped locomotion on challenging terrain suggests Viability (i.e., avoiding falls) as the main criterion for quadrupedal gait transitions and energy efficiency is the secondary objective.
- Milad Shafiee
- , Guillaume Bellegarda
- & Auke Ijspeert
-
Article
| Open AccessThe assembly platform FimD is required to obtain the most stable quaternary structure of type 1 pili
Type 1 pili are crucial cell surface bacterial virulence factors. Here, the authors show that FimD is required to assemble the most stable quaternary pilus structure by ensuring that the resulting protein polymer is free of structural defects.
- Dawid S. Zyla
- , Thomas Wiegand
- & Rudi Glockshuber
-
Article
| Open AccessComparative characterization of the infant gut microbiome and their maternal lineage by a multi-omics approach
Here, the authors employ multi-omics on a cohort comprising three generations of family members, showing that fecal microbiota populations, functions, and metabolome of infants vary greatly from their maternal lineage, exhibiting a less diverse microbiota and differences in various metabolite classes including short- and branched-chain fatty acids.
- Tomás Clive Barker-Tejeda
- , Elisa Zubeldia-Varela
- & Alma Villaseñor
-
Article
| Open AccessDermal injury drives a skin to gut axis that disrupts the intestinal microbiome and intestinal immune homeostasis in mice
The microbial community in the intestine can affect other organs such as the skin but it is not clear if the opposite can occur. Here the authors show that skin wounding affects the microbial composition of the intestinal flora which then enhances DSS induced colitis and intestinal inflammation.
- Tatsuya Dokoshi
- , Yang Chen
- & Richard L. Gallo
-
Article
| Open AccessA chromosomal-scale genome assembly of modern cultivated hybrid sugarcane provides insights into origination and evolution
Modern sugarcane cultivars have complicated genome due to interspecific crosses and multiple backcrossing. Here, the authors report the haplotype-resolved, chromosome-level genome assembly of a modern hybrid sugarcane cultivar and reveal the expansion of genes related to sugar accumulation and smut resistance.
- Yixue Bao
- , Qing Zhang
- & Muqing Zhang
-
Article
| Open AccessSingle-cell multiomics reveals the interplay of clonal evolution and cellular plasticity in hepatoblastoma
Hepatoblastoma (HB) is the most frequent paediatric liver tumour with heterogeneous cellular phenotypes that influence clinical outcomes. Here, the authors integrate bulk, single-cell, and spatial multi-omics to characterise HB cells, and find that clonal evolution and epigenetic plasticity shape response to therapy.
- Amélie Roehrig
- , Theo Z. Hirsch
- & Eric Letouzé
-
Article
| Open AccessEngineering an artificial catch bond using mechanical anisotropy
Catch bonds are unique protein-protein interactions where the bond lifetime increases under external pulling forces. Here, the authors engineer an artificial catch bond based on a non-catch bonding human gut bacterial adhesion protein complex.
- Zhaowei Liu
- , Haipei Liu
- & Michael A. Nash
-
Article
| Open AccessA chemical proteomics approach for global mapping of functional lysines on cell surface of living cell
Ligand discovery against membrane proteins has been a major challenge, mainly due to the peculiar nature of their natural habitat. Here, the authors designed a new chemical proteomic probe that targets the lysines exposed on the cell surface and developed a chemical proteomic strategy for global analysis of surface functionality in living cells.
- Ting Wang
- , Shiyun Ma
- & Haojie Lu
-
Article
| Open AccessCryo-EM structure of the human Asc-1 transporter complex
The human Asc-1-4F2hc complex plays an important role in the neural development and stability. Here, authors determine the cryo-EM structures of Asc-1-4F2hc complex in three states, revealing its substrate recognition and transport mechanism.
- Yaning Li
- , Yingying Guo
- & Renhong Yan
-
Article
| Open AccessAccurately clustering biological sequences in linear time by relatedness sorting
Accurately clustering biological sequences is an increasingly important task but is challenging for large datasets. This study introduces a new approach called ‘relatedness sorting’ to accurately cluster sequences with linear-time scalability.
- Erik Wright
Browse narrower subjects
- Biochemistry
- Biological techniques
- Biophysics
- Biotechnology
- Cancer
- Cell biology
- Chemical biology
- Computational biology and bioinformatics
- Developmental biology
- Drug discovery
- Ecology
- Evolution
- Genetics
- Immunology
- Microbiology
- Molecular biology
- Neuroscience
- Physiology
- Plant sciences
- Psychology
- Stem cells
- Structural biology
- Systems biology
- Zoology