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Article
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A brain-specific angiogenic mechanism enabled by tip cell specialization
A molecular mechanism for brain-specific angiogenesis operates under the control of Wnt7a/b ligands.
- Giel Schevenels
- , Pauline Cabochette
- & Benoit Vanhollebeke
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Article
| Open Access
Molecular insights into capsular polysaccharide secretion
An ensemble of cryo-electron microscopy structures of the KpsMT ABC transporter in complex with the KpsE co-polymerase and a glycolipid substrate reveal how capsular polysaccharides are recognized and translocated across bacterial cell membranes.
- Jeremi Kuklewicz
- & Jochen Zimmer
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Article |
Fossils document evolutionary changes of jaw joint to mammalian middle ear
A new morganucodontan-like species from the Jurassic in China shows evidence of a loss of load-bearing function in the articular–quadrate jaw joint, which probably had a role in the evolution of the mammalian middle ear.
- Fangyuan Mao
- , Chi Zhang
- & Jin Meng
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Article |
Jurassic shuotheriids show earliest dental diversification of mammaliaforms
A newly described fossil mammaliaform from the Jurassic period of China shows that the shuotheriids are allied to the docodonts, and provides details on the processes of tooth evolution in early mammals.
- Fangyuan Mao
- , Zhiyu Li
- & Jin Meng
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Article
| Open Access
Ancestral allele of DNA polymerase gamma modifies antiviral tolerance
The POLG1 mutation p.W748S, which is associated with mitochondrial recessive ataxia syndrome, dampens innate immune responses by compromising mtDNA replisome stability, and this explains why a viral infection can trigger the development of the disease and contribute to its variable clinical manifestation.
- Yilin Kang
- , Jussi Hepojoki
- & Anu Suomalainen
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News |
Right- or left-handed? Protein in embryo cells might help decide
Gene that codes for structural protein could determine the dominant side of the human brain.
- Sumeet Kulkarni
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Correspondence |
Adopt universal standards for study adaptation to boost health, education and social-science research
- Dragos Iliescu
- & Samuel Greiff
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News & Views |
Why hand-operated front brakes were set to be the future of motoring
The complexity of fitting brakes to all four wheels of a car and the simplicity of John Maynard Smith’s ecological models, in the weekly dip into Nature’s archive.
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News |
Gut bacteria break down cholesterol — hinting at probiotic treatments
Species in the human microbiome have enzymes that can metabolize a potentially dangerous lipid.
- Julian Nowogrodzki
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News |
‘Mini liver’ will grow in person’s own lymph node in bold new trial
Biotechnology firm LyGenesis has injected donor cells into a person with liver failure for the first time.
- Max Kozlov
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News Feature |
Long COVID still has no cure — so these patients are turning to research
With key long COVID trials yet to yield results, people with the condition are trying to change how clinical trials are done.
- Rachel Fairbank
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Article |
Complexity of avian evolution revealed by family-level genomes
- Josefin Stiller
- , Shaohong Feng
- & Guojie Zhang
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Technology Feature |
How synthetic biologists are building better biofactories
Artificial electron donors and acceptors expand researchers’ metabolic engineering options — if only cells would cooperate.
- Sara Reardon
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News |
Scientists made a six-legged mouse embryo — here’s why
A rodent with two extra limbs instead of genitals shows the crucial role of a gene pathway in determining the fate of a primordial structure.
- Sara Reardon
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Outline |
Video: Cancer-busting vaccines
Treatments that could train the immune system to identify and destroy cancer cells are on the way.
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Outline |
Cancer-vaccine trials give reasons for optimism
Therapeutic vaccines could provide a transformative shot in the arm for cancer treatment.
- Liam Drew
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Outline |
How does a cancer vaccine work?
After decades of slow progress, therapeutic vaccines that direct the immune system to attack tumours could soon become a fixture of cancer treatment.
- Liam Drew
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News |
How to make an old immune system young again
Antibodies that target blood stem cells can rejuvenate immune responses in mice.
- Heidi Ledford
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News & Views |
Anti-ageing antibodies revive the immune system
Depleting an expanding pool of aberrant stem cells in aged mice using antibody therapy has been shown to rebalance blood cell production, diminish age-associated inflammation and strengthen acquired immune responses.
- Yasar Arfat T. Kasu
- & Robert A. J. Signer
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News & Views |
Innate immunity in neurons makes memories persist
A population of neurons that engages mechanisms of the innate immune system during memory formation has been uncovered in mice. Surprisingly, inflammatory signalling might pave the way for long-term memory.
- Benjamin A. Kelvington
- & Ted Abel
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News & Views |
Climate change predicted to exacerbate declines in bee populations
What effects will climate change have on insect communities? Analyses of data collected over decades robustly document consequences specific to bee populations, and this evidence might aid future conservation efforts.
- Nicole E. Miller-Struttmann
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Article
| Open Access
Revealing uncertainty in the status of biodiversity change
This study presents an approach to deal with spatial, temporal and phylogenetic non-independence in large-scale analyses of biodiversity change, improving trend estimation and inference across scales.
- T. F. Johnson
- , A. P. Beckerman
- & R. P. Freckleton
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Nature Podcast |
How climate change is affecting global timekeeping
Melting polar ice could delay major time adjustment, and the strange connection between brain inflammation and memory.
- Elizabeth Gibney
- & Nick Petrić Howe
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Article
| Open Access
Formation of memory assemblies through the DNA-sensing TLR9 pathway
Learning results in persistent double-stranded DNA breaks, nuclear rupture and release of DNA fragments and histones within hippocampal CA1 neurons that, following TLR9-mediated DNA damage repair, results in their recruitment to memory circuits.
- Vladimir Jovasevic
- , Elizabeth M. Wood
- & Jelena Radulovic
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Article |
Depleting myeloid-biased haematopoietic stem cells rejuvenates aged immunity
Antibody-mediated depletion of myeloid-biased haematopoietic stem cells in aged mice restores characteristic features of a more youthful immune system.
- Jason B. Ross
- , Lara M. Myers
- & Irving L. Weissman
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Article
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The complex polyploid genome architecture of sugarcane
We build a polyploid reference genome for hybrid sugarcane cultivar R570, improving on its current ‘mosaic monoploid’ representation, enabling fine-grain description of genome architecture and the exploration of candidate genes underlying the Bru1 brown rust resistance locus.
- A. L. Healey
- , O. Garsmeur
- & A. D’Hont
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Research Briefing |
Mouse brains respond differently to observed threat and direct danger
Humans and other social animals are highly adept at learning by observing how others interact with the environment, especially when identifying potential sources of danger. In mice, a specific brain region acts as an information-processing hub that distinguishes between observed and directly experienced fear, and signals different behavioural responses accordingly.
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News & Views |
The race to uncover fission factors for lysosomal organelles heats up
Organelles called lysosomes fuse with cargo-carrying vesicles and degrade the cargo molecules. How lysosomes maintain their size despite constant vesicle fusion was unclear, but now factors that aid organelle fission have been found.
- Shilpa Gopan
- & Thomas J. Pucadyil
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Article |
The HEAT repeat protein HPO-27 is a lysosome fission factor
The conserved HEAT repeat protein HPO-27 is identified as a lysosome scission factor in Caenorhabditis elegans, and the human homologue MROH1 also serves the same function to maintain lysosomal homeostasis.
- Letao Li
- , Xilu Liu
- & Xiaochen Wang
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Article |
TRBC1-targeting antibody–drug conjugates for the treatment of T cell cancers
Anti-TRBC1 antibody–drug conjugates may offer a more potent T cell cancer therapy by bypassing the fratricide that may be limiting the efficacy of anti-TRBC1 CAR T cells in the clinical trial for patients with T cell cancers.
- Tushar D. Nichakawade
- , Jiaxin Ge
- & Suman Paul
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Article
| Open Access
Single-cell multiplex chromatin and RNA interactions in ageing human brain
We introduce multinucleic acid interaction mapping in single cells (MUSIC), for concurrent profiling of multiplex chromatin interactions, gene expression and RNA–chromatin associations within individual nuclei, as a tool for exploring chromatin architecture and transcription.
- Xingzhao Wen
- , Zhifei Luo
- & Sheng Zhong
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Article |
Heat and desiccation tolerances predict bee abundance under climate change
A 16-year dataset of abundance patterns of a diverse assemblage of bees in New Mexico, USA predicts declines for many bee species and indicates that drought-tolerant taxa will prevail in a warming and drying climate.
- Melanie R. Kazenel
- , Karen W. Wright
- & Jennifer A. Rudgers
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News |
Memories are made by breaking DNA — and fixing it
Nerve cells form long-term memories with the help of an inflammatory response, study in mice finds.
- Max Kozlov
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Article
| Open Access
CGRP sensory neurons promote tissue healing via neutrophils and macrophages
Experiments in mouse models show that NaV1.8+ nociceptors innervate sites of injury and provide wound repair signals to immune cells by releasing calcitonin gene-related peptide (CGRP).
- Yen-Zhen Lu
- , Bhavana Nayer
- & Mikaël M. Martino
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Article |
Structural basis of exoribonuclease-mediated mRNA transcription termination
A study presents two cryo-EM structures of yeast Pol II pre-termination transcription complexes bound to Rat1–Rai1, and provides the mechanisms for termination of mRNA transcription in yeast and other eukaryotes.
- Yuan Zeng
- , Hong-Wei Zhang
- & Yu Zhang
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Article |
Targeting DCAF5 suppresses SMARCB1-mutant cancer by stabilizing SWI/SNF
DCAF5 has a quality-control function for SWI/SNF complexes and promotes the degradation of incompletely assembled SWI/SNF complexes in the absence of SMARCB1.
- Sandi Radko-Juettner
- , Hong Yue
- & Charles W. M. Roberts
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Article
| Open Access
Climate velocities and species tracking in global mountain regions
An analysis of the rate at which isotherms are shifting in mountain regions worldwide identifies 17 key regions with particularly high vertical isotherm shift velocities, and provides insight into how these shifts affect species ranges.
- Wei-Ping Chan
- , Jonathan Lenoir
- & Sheng-Feng Shen
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Article
| Open Access
A brainstem–hypothalamus neuronal circuit reduces feeding upon heat exposure
In response to acute thermal challenge, thermosensing glutamatergic neurons of the parabrachial nucleus in mouse brain activate tanycytes, which reduce the excitability of Flt1-expressing dopamine and agouti-related peptide-containing neurons, thus suppressing appetite.
- Marco Benevento
- , Alán Alpár
- & Tibor Harkany
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Research Highlight |
A test for Alzheimer’s-disease stage predicts dementia risk
Levels of a host of molecules in the cerebrospinal fluid reliably assess development of the disease.
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Obituary |
Estella Bergere Leopold (1927–2024), passionate environmentalist who traced changing ecosystems
The trailblazing palaeobotanist investigated how climate change affected Earth in the past — and firmly believed science should be used in its defence now.
- Cathy Whitlock
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News Feature |
The ‘Mother Tree’ idea is everywhere — but how much of it is real?
A popular theory about how trees cooperate has enchanted the public and raised the profile of forest conservation. But some ecologists think its scientific basis has been oversold.
- Aisling Irwin
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Career Q&A |
The beauty of what science can do when urgently needed
Working amid New York City’s pandemic response inspired Nili Ostrov’s approach to expanding the list of organisms that can be used in synthetic biology and engineering.
- Katherine Bourzac
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Comment |
How a tree-hugging protest transformed Indian environmentalism
Fifty years ago, a group of women from the villages of the Western Himalayas sparked Chipko, a green movement that remains relevant in the age of climate change.
- Seema Mundoli
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News Feature |
How AI is improving climate forecasts
Researchers are using various machine-learning strategies to speed up climate modelling, reduce its energy costs and hopefully improve accuracy.
- Carissa Wong
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Nature Careers Podcast |
‘Hopeless, burnt out, sad’: how political change is impacting female researchers in Latin America
Already feeling invisible and unappreciated, the election of far-right administrations in Argentina and elsewhere are unsettling for women in science.
- Julie Gould
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News |
Pregnancy advances your ‘biological’ age — but giving birth turns it back
Carrying a baby creates some of the same epigenetic patterns on DNA seen in older people.
- Saima Sidik
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News |
First pig kidney transplant in a person: what it means for the future
The operation’s early success has made researchers hopeful that clinical trials for xenotransplanted organs will start soon.
- Smriti Mallapaty
- & Max Kozlov
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News |
Google AI could soon use a person’s cough to diagnose disease
Machine-learning system trained on millions of human audio clips shows promise for detecting COVID-19 and tuberculosis.
- Mariana Lenharo
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Outlook |
The future of at-home molecular testing
The COVID-19 pandemic showed what was possible for gene-based diagnostics. Now comes the true test – economics.
- Elie Dolgin
Structural basis of Integrator-dependent RNA polymerase II terminationBrowse narrower subjects
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