Bioinorganic chemistry

Bioinorganic chemistry is the study of the structures and biological functions of inorganic biological substances, that is, those not containing carbon, such as metals.

Latest Research and Reviews

News and Comment

  • Comments & Opinion
    | Open Access

    First-row transition metals play several roles in biological processes and in medicine, but can be toxic in high concentrations. Here the authors comment on the sensitive biochemistry and speciation chemistry of the first-row transition metals, and outline some of the remaining questions that have yet to be answered.

    • Debbie C. Crans
    •  & Kateryna Kostenkova
  • News & Views |

    The regulation of brain iron homeostasis, previously thought to be cell autonomous and modulated by local factors in the interstitial fluid, is reported by Wang et al. to be strongly influenced by axonal transport of iron in an activity-dependent and unidirectional manner between functionally associated regions. The supply of iron from the ventral hippocampus to the middle prefrontal cortex subserved an anxiolytic phenotype and mediated the neuropharmacological actions of diazepam and lithium chloride in rodent models.

    • Peng Lei
    • , Scott Ayton
    •  & Ashley I. Bush
    Nature Chemical Biology 15, 1135-1136
  • Research Highlights |

    Thin films of hydrogenase enzymes dispersed in a redox-active gel effect rapid anodic oxidation of H2 even in the presence of O2.

    • David Schilter
  • News & Views |

    A recent study reports the first high-resolution, cryo-electron microscopy-based structure of zebrafish Na+-K+-Cl cotransporter 1 (NKCC1). This structure provides important insights into the determinants of ion translocation by NKCC1 and other cation-Cl cotransporters such as NKCC2. It could thus facilitate the design of drugs to target these transporters individually.

    • Alexandre P. Garneau
    •  & Paul Isenring