Nature

Biochemistry articles from across Nature Portfolio

Biochemistry is the study of the structure and function of biological molecules such as proteins, nucleic acids, carbohydrates and lipids. Biochemistry is also used to describe techniques suited to understanding the interactions and functions of biological molecules, including traditional techniques such as Western blotting, co-immunoprecipitation, and chromatography methods.

Featured

The great escape — how inorganic phosphate is released from actin filaments

The release of inorganic phosphate (P_i) from actin marks old actin filaments for disassembly. By combining cryo-electron microscopy (cryo-EM) with in vitro reconstitution and molecular dynamics simulations, we show how actin filaments release P_i through a ‘molecular backdoor’ and demonstrate that this arrangement is distorted in a disease-linked actin variant.

News & Views29 Sept 2023 Nature Structural & Molecular Biology
P: 1-2
NO signal

The susceptibility of nitric oxide (NO) to scavenging and oxidation limits its bioavailability and signaling role. New studies indicate that a NO–ferroheme adduct is resistant to such constraints and may serve as an alternative NO-derived signaling molecule in vasculature.
- Emil Martin
News & Views14 Sept 2023 Nature Chemical Biology
Volume: 19, P: 1178-1179
Complex regulatory processes control exercise adaptations of skeletal muscle

The molecular underpinnings of the extensive cellular, morphological and functional plasticity of skeletal muscle in exercise training are poorly understood. We have now begun to unravel the complex epigenetic, transcriptional and proteomic networks that determine the muscle response to exercise in a manner depending on the training state.

News & Views14 Sept 2023 Nature Metabolism
P: 1-2

Related Subjects

Latest Research and Reviews

Coupled catalytic states and the role of metal coordination in Cas9

Cas9 is a powerful genome-manipulation enzyme, although how its catalytic activity is controlled is not completely solved. Now, cryo-electron microscopy structures of Acidothermus cellulolyticus Cas9 provide atomic-level insights into its activation involving DNA binding, conformational changes and the formation of its two active sites.
- Anuska Das
- Jay Rai
- Hong Li
ResearchOpen Access02 Oct 2023 Nature Catalysis
P: 1-9
A stepwise activation model for the insulin receptor
- Na-Oh Yunn
- Junhong Kim
- Yunje Cho
ReviewsOpen Access02 Oct 2023 Experimental & Molecular Medicine
P: 1-15
Immobilized enzyme microreactors for analysis of tryptic peptides in β-casein and β-lactoglobulin
- Agnieszka Rodzik
- Viorica Railean
- Michał Szumski
ResearchOpen Access02 Oct 2023 Scientific Reports
Volume: 13, P: 16551
Phosphocode-dependent glutamyl-prolyl-tRNA synthetase 1 signaling in immunity, metabolism, and disease
- Eun-Young Lee
- Jungwon Hwang
- Myung Hee Kim
ReviewsOpen Access02 Oct 2023 Experimental & Molecular Medicine
P: 1-11
Mechanisms controlling cellular and systemic iron homeostasis

Iron homeostasis in animals is tightly controlled, and numerous cellular pathways regulate iron uptake, storage, metabolism and secretion. Recent findings provide new insights into the sensory systems that fine-tune iron homeostasis and explain how cellular and systemic iron fluxes intersect.
- Bruno Galy
- Marcus Conrad
- Martina Muckenthaler
Reviews02 Oct 2023 Nature Reviews Molecular Cell Biology
P: 1-23
Lipocalin-2: a therapeutic target to overcome neurodegenerative diseases by regulating reactive astrogliosis
- Byung-Kwon Jung
- Kwon-Yul Ryu
ReviewsOpen Access02 Oct 2023 Experimental & Molecular Medicine
P: 1-9

All Research & Reviews

News and Comment

The great escape — how inorganic phosphate is released from actin filaments

The release of inorganic phosphate (P_i) from actin marks old actin filaments for disassembly. By combining cryo-electron microscopy (cryo-EM) with in vitro reconstitution and molecular dynamics simulations, we show how actin filaments release P_i through a ‘molecular backdoor’ and demonstrate that this arrangement is distorted in a disease-linked actin variant.

News & Views29 Sept 2023 Nature Structural & Molecular Biology
P: 1-2
Lasker Award for AlphaFold

Congratulations to John Jumper and Demis Hassabis for winning the 2023 Albert Lasker Basic Medical Research Award.
- Paulina Strzyz
Research Highlights26 Sept 2023 Nature Reviews Molecular Cell Biology
P: 1
Uncovering ensembles
- Sophie McKenna
Research Highlights25 Sept 2023 Nature Chemical Biology
Volume: 19, P: 1172
Scrambling viral infection
- Benjamin McIlwain
Research Highlights25 Sept 2023 Nature Chemical Biology
Volume: 19, P: 1173
In memoriam: Eugene S Paykel, MD, FRCP, FRCPsych, FMedSci
- Barbara J. Sahakian
- Eileen M. Joyce
- Trevor W. Robbins
Comments & Opinion23 Sept 2023 Neuropsychopharmacology
P: 1
Boosted electrostatic biocatalysis
- Jan-Stefan Völler
Research Highlights22 Sept 2023 Nature Catalysis
Volume: 6, P: 742

All News & Comment

Search

Advanced search

Quick links