Biochemistry

Biochemistry is the study of the structure and function of biological molecules such as proteins, nucleic acids, carbohydrates and lipids. Biochemistry is also used to describe techniques suited to understanding the interactions and functions of biological molecules, including traditional techniques such as Western blotting, co-immunoprecipitation, and chromatography methods.

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Latest Research and Reviews

News and Comment

  • News and Views |

    The longstanding ‘polyelectrolyte theory of the gene’ proposes that a multiply charged backbone is the universal signature of all genetic polymer systems that support life. Now, the first tenable challenge to this theory has been mounted, through the successful engineering of enzymes which can synthesize and reverse-transcribe from an artificial, uncharged nucleic acid analogue.

    • Asha Brown
    •  & Tom Brown
    Nature Chemistry 11, 501-503
  • News and Views |

    Over-expression of a transcriptional factor, Alx3, has been shown to revitalize the regenerative capacity of adult progenitor cells to promote enhanced stromal vascularization and formation of parenchymal dental pulp tissue in vivo.

    • Sarah E. Millar
    Nature Materials 18, 530-531
  • Research Highlights |

    Thermal denaturation of proteins affords species that differ in terms of cofactors and conformations. Ion mobility spectrometry and mass spectrometry can be used to unravel these mixtures and learn the factors stabilizing certain protein forms.

    • David Schilter
  • Comments and Opinion |

    Zeolites and other technologies should be evaluated and pursued for reducing methane concentrations in the atmosphere from 1,860 ppb to preindustrial levels of ~750 ppb. Such a goal of atmospheric restoration provides a positive framework for change at a time when climate action is desperately needed.

    • R. B. Jackson
    • , E. I. Solomon
    • , J. G. Canadell
    • , M. Cargnello
    •  & C. B. Field
  • News and Views |

    IRE1α is an endoplasmic reticulum (ER) transmembrane protein known for a crucial role in regulating the unfolding protein response. A study now shows that IRE1α interacts with the main ER Ca2+ channel InsP3Rs and facilitates the transfer of Ca2+ from the ER into mitochondria, thus driving cellular metabolism.

    • Roland Malli
    •  & Wolfgang F. Graier