Biochemistry

Definition

Biochemistry is the study of the structure and function of biological molecules such as proteins, nucleic acids, carbohydrates and lipids. Biochemistry is also used to describe techniques suited to understanding the interactions and functions of biological molecules, including traditional techniques such as Western blotting, co-immunoprecipitation, and chromatography methods.

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Latest Research and Reviews

  • Research |

    Metabolic flux analysis in mice reveals that lactate often acts as the primary carbon source for the tricarboxylic acid cycle both in normal tissues and in tumour microenvironments.

    • Sheng Hui
    • , Jonathan M. Ghergurovich
    • , Raphael J. Morscher
    • , Cholsoon Jang
    • , Xin Teng
    • , Wenyun Lu
    • , Lourdes A. Esparza
    • , Tannishtha Reya
    • , Le Zhan
    • , Jessie Yanxiang Guo
    • , Eileen White
    •  & Joshua D. Rabinowitz
  • Research |

    Identification of a transmembrane protein, Mfsd2b, that is essential for the export of the signalling molecule sphingosine-1-phosphate (S1P) from red blood cells and platelets.

    • Thiet M. Vu
    • , Ayako-Nakamura Ishizu
    • , Juat Chin Foo
    • , Xiu Ru Toh
    • , Fangyu Zhang
    • , Ding Ming Whee
    • , Federico Torta
    • , Amaury Cazenave-Gassiot
    • , Takayoshi Matsumura
    • , Sangho Kim
    • , Sue-Anne E. S. Toh
    • , Toshio Suda
    • , David L. Silver
    • , Markus R. Wenk
    •  & Long N. Nguyen
  • Research |

    Small molecules are identified that inhibit the ubiquitin-specific protease USP7 with high affinity and specificity as explained by co-crystal structures, and are shown to reduce tumour growth in mice.

    • Andrew P. Turnbull
    • , Stephanos Ioannidis
    • , Wojciech W. Krajewski
    • , Adan Pinto-Fernandez
    • , Claire Heride
    • , Agnes C. L. Martin
    • , Louise M. Tonkin
    • , Elizabeth C. Townsend
    • , Shane M. Buker
    • , David R. Lancia
    • , Justin A. Caravella
    • , Angela V. Toms
    • , Thomas M. Charlton
    • , Johanna Lahdenranta
    • , Erik Wilker
    • , Bruce C. Follows
    • , Nicola J. Evans
    • , Lucy Stead
    • , Cristina Alli
    • , Vladislav V. Zarayskiy
    • , Adam C. Talbot
    • , Alexandre J. Buckmelter
    • , Minghua Wang
    • , Crystal L. McKinnon
    • , Fabienne Saab
    • , Joanna F. McGouran
    • , Hannah Century
    • , Malte Gersch
    • , Marc S. Pittman
    • , C. Gary Marshall
    • , Tony M. Raynham
    • , Mary Simcox
    • , Lorna M. D. Stewart
    • , Sheila B. McLoughlin
    • , Jaime A. Escobedo
    • , Kenneth W. Bair
    • , Christopher J. Dinsmore
    • , Tim R. Hammonds
    • , Sunkyu Kim
    • , Sylvie Urbé
    • , Michael J. Clague
    • , Benedikt M. Kessler
    •  & David Komander
  • Research |

    Single-particle cryo-electron microscopy is used to resolve the structure of the phycobilisome, a 16.8-megadalton light-harvesting megacomplex, from the red alga Griffithsia pacifica at a resolution of 3.5 Å.

    • Jun Zhang
    • , Jianfei Ma
    • , Desheng Liu
    • , Song Qin
    • , Shan Sun
    • , Jindong Zhao
    •  & Sen-Fang Sui
  • Research | | open

    Hydrogen sulfide (H2S) from agricultural sources is generally omitted from sulfur emission estimates despite its abundance in livestock emissions. Here, the authors show that agriculture is the most important source of sulfur in Denmark using proton-transfer-reaction mass spectrometry measurements of H2S.

    • Anders Feilberg
    • , Michael Jørgen Hansen
    • , Dezhao Liu
    •  & Tavs Nyord

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