Basal ganglia

Simultaneous fMRI-EEG in 26 healthy participants indicate that the basal ganglia cortical network and the neurofeedback control network play different roles in self-regulation, providing further insight into the neural correlates for brain-machine interface control and feedback.

Experiments in mice show that direct- and indirect-pathway neurons in the basal ganglia are co-activated during movement but exhibit opposite patterns of activity during the active suppression of movement.

Integrated analysis of external pallidum (GPe) neuronal firing, pupil size, and saccadic movements in non-human primates reveals that pauses in GPe firing are associated with pupil dilation. These results suggest that pauses in GPe activity might influence downstream structures in the basal ganglia network and influence exploratory behavior.

2- arachidonoylglycerol (2-AG), an abundant endocannabinoid in the brain, regulates diverse neural functions. Here, the authors identified four loss-of-function mutations in dicylglycerol lipase β (DAGLB) from six patients with early onset Parkinsonism. In mice, loss of DAGLB in dopamine neurons reduced neuronal activity and impaired locomotor function and augmentation of 2-AG levels boosted neuronal activity and rescued locomotor deficits.