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| Open AccessMotor cortex gates distractor stimulus encoding in sensory cortex
The neocortex can filter out stimuli that distract us from our goals. Here the authors demonstrate in mice a mechanism of distractor filtering, in which top-down inputs from motor cortex to sensory cortex prevents the internal propagation of distractor stimuli.
- Zhaoran Zhang
- & Edward Zagha
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Article
| Open AccessTuning instability of non-columnar neurons in the salt-and-pepper whisker map in somatosensory cortex
Rodent sensory cortex contains intermixed representations of sensory features. Here the authors investigated the whisker somatotopic map among L2/3 pyramidal neurons in somatosensory cortex in awake mice performing a sensory discrimination task.
- Han Chin Wang
- , Amy M. LeMessurier
- & Daniel E. Feldman
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| Open AccessDistinct organization of two cortico-cortical feedback pathways
Cortical activity is modulated by an intricate network of feedforward and feedback connectivity. Here the authors demonstrate distinct organizational rules govern feedback projections from lateral medial area to V1 versus projections from vibrissal M1 to vibrissal S1.
- Shan Shen
- , Xiaolong Jiang
- & Andreas S. Tolias
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| Open AccessLearning enhances encoding of time and temporal surprise in mouse primary sensory cortex
Activity in the superficial layers of the sensory cortex is believed to be largely driven by incoming sensory stimuli. Here the authors demonstrate how learning changes neural responses to sensations according to both behavioral relevance and timing, suggesting a high degree of non-sensory modulation.
- Rebecca J. Rabinovich
- , Daniel D. Kato
- & Randy M. Bruno
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| Open AccessTransformation of primary sensory cortical representations from layer 4 to layer 2
The transform performed by superficial primary sensory cortex is poorly understood. Here the authors show that sensory stimulus-evoked activity shifts from a broadly distributed, probabilistic response in cortical layer 4 to a sparse and robust ensemble-based response in cortical layer 2.
- Bettina Voelcker
- , Ravi Pancholi
- & Simon Peron
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| Open AccessOlfactory modulation of barrel cortex activity during active whisking and passive whisker stimulation
Rodents use both touch and smell to get around. This work describes how olfactory information is combined with touch perception in the cortex to guide behavior.
- Anthony Renard
- , Evan R. Harrell
- & Brice Bathellier
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Article
| Open AccessDistinct nociception processing in the dysgranular and barrel regions of the mouse somatosensory cortex
The processing of nociception in the somatosensory cortex (S1) has yet to be fully understood. Here, the authors demonstrate that the dysgranular region in S1 has an affinity for nociception and is critically involved in pain-like behavior.
- Hironobu Osaki
- , Moeko Kanaya
- & Mariko Miyata
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Article
| Open AccessReduction of corpus callosum activity during whisking leads to interhemispheric decorrelation
Interhemispheric correlations are mediated by the corpus callosum, an extensive fiber bundle connecting the cortical hemispheres. The authors show that interhemispheric correlations between the somatosensory cortices of awake mice are reduced during whisking as a result of lower callosal activity.
- Yael Oran
- , Yonatan Katz
- & Ilan Lampl
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| Open AccessBarrel cortex plasticity after photothrombotic stroke involves potentiating responses of pre-existing circuits but not functional remapping to new circuits
Definitive evidence for functional remapping after stroke remains lacking. Here, the authors performed in vivo intrinsic signal imaging and two-photon calcium imaging of sensory-evoked responses before and after photothrombotic stroke and found no evidence of remapping of lost functionalities to new circuits in peri-infarct cortex.
- William A. Zeiger
- , Máté Marosi
- & Carlos Portera-Cailliau
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| Open AccessDevelopmental divergence of sensory stimulus representation in cortical interneurons
Sensory neuronal circuits adapt during maturation when animals start to actively interact with the external world. The authors reveal structural and functional rearrangements of the input cortical interneurons receive around the time the animals start active sensation.
- Rahel Kastli
- , Rasmus Vighagen
- & Theofanis Karayannis
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| Open AccessAnatomically and functionally distinct thalamocortical inputs to primary and secondary mouse whisker somatosensory cortices
The thalamus provides sensory input to the cortex, but many aspects of thalamocortical signaling remain unknown. Here, the authors reveal parallel non-overlapping thalamic pathways with distinct representations of tactile and decision-related information during a goal-directed sensorimotor task.
- Sami El-Boustani
- , B. Semihcan Sermet
- & Carl C. H. Petersen
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| Open AccessDynamic perceptual feature selectivity in primary somatosensory cortex upon reversal learning
Do cortical neurons stably represent stimulus features in different contexts? Here, using calcium imaging, the authors show that texture selectivity of individual neurons is dynamic during reversal learning. For a subclass this is contingent on the associated reward and forecasts the onset of learning.
- Ronan Chéreau
- , Tanika Bawa
- & Anthony Holtmaat
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| Open AccessRich spatio-temporal stimulus dynamics unveil sensory specialization in cortical area S2
Sensory tuning properties of neurons in the secondary whisker somatosensory cortex (wS2) are not well understood. Here, the authors report that wS2 neurons supralinearly integrate concurrent multi-whisker input with larger temporal windows than primary somatosensory cortex.
- Matías A. Goldin
- , Evan R. Harrell
- & Daniel E. Shulz
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Article
| Open AccessTopographic precision in sensory and motor corticostriatal projections varies across cell type and cortical area
How corticostriatal connections of different pyramidal cell types are organized, particularly in convergent circuits, has not been evaluated in detail. Here, cell type-specific Cre-driver mice reveal that pyramidal tract-type corticostriatal projections, though broadly similar to intratelencephalic-type projections from the same cortical region, are generally more restricted and variable in their topographic termination patterns.
- Bryan M. Hooks
- , Andrew E. Papale
- & Charles R. Gerfen
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| Open AccessDifferential dynamics of cortical neuron dendritic trees revealed by long-term in vivo imaging in neonates
Layer 4 stellate neurons in barrel cortex have a characteristic dendritic pattern. Here, the authors conduct long-term imaging from postnatal day 3–6 to show that an orientation bias is established through dendritic tree turnover and selective elaboration, which may be induced by biased thalamocortical inputs.
- Shingo Nakazawa
- , Hidenobu Mizuno
- & Takuji Iwasato
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| Open AccessSingle synaptic inputs drive high-precision action potentials in parvalbumin expressing GABA-ergic cortical neurons in vivo
In superficial layers of the cortex, excitatory neurons often fire single action potentials. Here, using multiple whole-cell recordings in vivo, the authors show that single excitatory synaptic events can drive GABA-ergic parvalbumin neurons to fire, triggering inhibition of other pyramidal neurons.
- Jean-Sébastien Jouhanneau
- , Jens Kremkow
- & James F. A. Poulet
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Article
| Open AccessA radial map of multi-whisker correlation selectivity in the rat barrel cortex
Barrel cortex contains a functional map of whiskers but how neuronal activity maps multi-whisker inputs has not been studied. Here the authors show that while uncorrelated multi-whisker stimuli activate barrel neurons, correlated multi-whisker inputs activate neurons in a ring at the barrel-septa boundary
- Luc Estebanez
- , Julien Bertherat
- & Jean- François Léger
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| Open AccessLocal and thalamic origins of correlated ongoing and sensory-evoked cortical activities
Sensory cortices receive input from cortical cells and the thalamus, yet it is unknown how these inputs interact to generate synchronous activity. Here authors show that unlike cortical inputs, thalamic inputs are asynchronous, suggesting that cortical synchronization is due to intracortical coupling.
- Katayun Cohen-Kashi Malina
- , Boaz Mohar
- & Ilan Lampl
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| Open AccessWhisker barrel cortex delta oscillations and gamma power in the awake mouse are linked to respiration
Oscillatory neuronal activity in the mammalian neocortex is implicated in cognitive processes but its generation is poorly understood. In this study, the authors show that delta band oscillatory activity in mice phase-locks with respiratory activity and that this is mediated by activity in the olfactory bulb.
- J. Ito
- , S. Roy
- & D.H. Heck