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As a leading cause of diarrhoeal mortality and morbidity, authors examine the epidemiology and genome dynamics of shigellosis in South Africa, utilising whole genome sequence analysis.
Virtual screening, biochemical assays, and coarse-grained simulations identify an inhibitor of energy-coupling factor transporters and its potential mechanism of action.
Jimmy Nkaiwuatei is the Head of Research, Discovery and Innovations at Students Against Superbugs Africa, a youth-led organization tackling the problem of antimicrobial resistance through education and outreach in Africa.
Current acellular pertussis vaccines prevent disease but do not prevent nasal infection and transmission of Bordetella pertussis. However, immunology is helping to design new vaccines that induce sterilizing immunity.
A hierarchical Bayesian method identifies cell-type specific changes in gene regulatory circuits in disease by integrating single-cell and three-dimensional measurements of the genome.
